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Les derniers abstracts de la revue Gastroenterology :


    Date de mise en ligne : Vendredi 21 juillet 2017
    Ilaria Pergolini, Klaus Sahora, Cristina R. Ferrone, Vicente Morales-Oyarvide, Brian M. Wolpin, Lorelei A. Mucci, William R. Brugge, Mari Mino-Kenudson, Manuel Patino, Dushyant V. Sahani, Andrew L. Warshaw, Keith D. Lillemoe, Carlos FernĂĄndez-del Castillo
    Long-Term Risk of Pancreatic Malignancy in Patients with Branch Duct Intraductal Papillary Mucinous Neoplasm in A Referral Center
    Little is known about development of branch duct intraductal papillary mucinous neoplasms (BD-IPMNs). We evaluated long-term outcomes of a large cohort of patients with BD-IPMNs to determine risk of malignancy and define a subset of low-risk BD-IPMNs.


    Date de mise en ligne : Jeudi 20 juillet 2017
    Alexander Larson, Ferga Gleeson, Elizabeth Rajan
    25-Year-Old female with a deceptive pancreas cyst: all is not as it appears!


    Date de mise en ligne : Mercredi 19 juillet 2017
    P. Woodland, J.L. Ooi, F. Grassi, K. Nikaki, C. Lee, J.A. Evans, N. Koukias, C. Triantos, S.A. McDonald, M. Peiris, R. Aktar, L.A. Blackshaw, D. Sifrim
    Superficial esophageal mucosal afferent nerves may contribute to reflux hypersensitivity in non-erosive reflux disease
    Little is known about the causes of heartburn in patients with gastro-esophageal reflux disease (GERD). Visible epithelial damage is seldom associated with symptom severity, evidenced by the significant symptom burden in patients with non-erosive reflux disease (NERD) compared to patients with erosive reflux disease (ERD) or Barrett’s esophagus (BE). We studied the distribution of mucosal nerve fibers in patients with NERD, ERD, and BE, and compared the results with those of healthy subjects.


    Date de mise en ligne : Mercredi 19 juillet 2017
    Sabela Lens, Edilmar Alvarado, Zoe Mariño, María-Carlota Londoño, Elba LLop, Javier Martinez, Jose Ignacio Fortea, Luís Ibañez, Xavier Ariza, Anna Baiges, Adolfo Gallego, Rafael Bañares, Angela Puente, Agustín Albillos, Jose Luís Calleja, Xavier Torras, Virginia Hernåndez-Gea, Jaume Bosch, Cåndid Villanueva, Xavier Forns, Juan Carlos García-Pagån
    Effects of All-oral Anti-viral Therapy on HVPG and Systemic Hemodynamics in Patients with Hepatitis C Virus-associated Cirrhosis
    Patients with hepatitis C virus (HCV)-associated cirrhosis and clinical significant portal hypertension (CSPH, hepatic venous pressure gradient [HVPG] 10 mmHg or greater), despite achieving sustained virological response (SVR) to therapy, remain at risk of liver decompensation. We investigated hemodynamic changes following SVR in patients with CSPH and whether liver stiffness measurements (LSMs) can rule out the presence of CSPH.


    Date de mise en ligne : Mercredi 19 juillet 2017
    Shivan J. Mehta, Jordyn Feingold, Matthew Vandertuyn, Tess Niewood, Catherine Cox, Chyke A. Doubeni, Kevin G. Volpp, David A. Asch
    Active Choice and Financial Incentives to Increase Rates of Screening Colonoscopy—a Randomized Controlled Trial
    Behavioral economic approaches could increase uptake for colorectal cancer screening. We performed a randomized controlled trial of 2245 employees to determine whether an email containing a phone number for scheduling (control), an email with the active choice to opt in or opt out (active choice), or the active choice email plus a $100 incentive (financial incentive) increased colonoscopy completion within 3 months. Higher proportions of participants in the financial incentive group underwent screening (3.7%) than in the control (1.6%) or active choice groups (1.5%) (P=.01 and P <.01).


    Date de mise en ligne : Mercredi 19 juillet 2017
    Hyuk Moon, Hye-Lim Ju, Sook In Chung, Kyung Joo Cho, Jung Woo Eun, Suk Woo Nam, Kwang-Hyub Han, Diego F. Calvisi, Simon Weonsang Ro
    Transforming Growth Factor Beta Promotes Liver Tumorigenesis in Mice via Upregulation of Snail
    Transforming growth factor beta (TGFB) suppresses early stages of tumorigenesis, but also contributes to migration and metastasis of cancer cells. A large number of human tumors contain mutations that inactivate its receptors, or downstream proteins such as Smad transcription factors, indicating that the TGFB signaling pathway prevents tumor growth. We investigated the effects of TGFB inhibition on liver tumorigenesis in mice.


    Date de mise en ligne : Mardi 18 juillet 2017
    Ming-Hung Hsu, Yi-Ju Chen, Wen-Lun Wang
    An unusual colon cystic tumor


    Date de mise en ligne : Mardi 18 juillet 2017
    Sreelakshmi Kotha, Ioannis Koumoutsos
    A case of mistaken identity


    Date de mise en ligne : Mardi 18 juillet 2017
    Yuichiro Rikitake, Shuhei Fukunaga, Hirohiko Abe
    Case of a young man with abdominal pain and jaundice


    Date de mise en ligne : Mardi 18 juillet 2017
    Juliette Gueguen, Guillaume Hanouna, Jonathan M. Chemouny
    Persistent hypokalemia with renal losses in a 31-year-old pregnant woman


    Date de mise en ligne : Mardi 18 juillet 2017
    Arjun R. Sondhi, Marc Piper, Matthew J. DiMagno
    Stack of coins sign in a patient with recurrent abdominal pain


    Date de mise en ligne : Mardi 18 juillet 2017
    Gaurav Ghosh, Nicole Shen, Arun B. Jesudian
    Coffee Bean Sign with a Twist


    Date de mise en ligne : Mardi 18 juillet 2017
    Robert S. Robinson, Rohan M. Modi, Somashekar G. Krishna
    Acute Abdominal Pain and Hematochezia in a Long-Distance Runner


    Date de mise en ligne : Mardi 18 juillet 2017
    Paul Lochhead, Kaitlin Hagan, Amit D. Joshi, Hamed Khalili, Long H. Nguyen, Francine Grodstein, Andrew T. Chan
    Association Between Proton Pump Inhibitor Use and Cognitive Function in Women
    Studies have reported associations between proton pump inhibitor (PPI) use and dementia. However, data are lacking on long-term PPI use and cognitive function. We therefore examined associations between PPI use and performance in tests of cognitive function. Because of shared clinical indications, we examined associations for H2 receptor antagonists (H2RAs) as a secondary aim.


    Date de mise en ligne : Vendredi 14 juillet 2017
    Sander P.J. Joosten, Jurrit Zeilstra, Harmen van Andel, R. Clinton Mijnals, Joost Zaunbrecher, Annet A.M. Duivenvoorden, Marc van de Wetering, Hans Clevers, Marcel Spaargaren, Steven T. Pals
    MET Signaling Mediates Intestinal Crypt Villus Development, Regeneration, and Adenoma Formation and is Promoted by Stem Cell CD44 Isoforms
    Resistance of metastatic human colorectal cancer cells to drugs that block epidermal growth factor receptor (EGFR) signaling could be caused by aberrant activity of other receptor tyrosine kinases, activating overlapping signaling pathways. One of these receptor tyrosine kinases could be MET, the receptor for hepatocyte growth factor (HGF). We investigated how MET signaling, and its interaction with CD44 (a putative MET co-receptor regulated by Wnt signaling and highly expressed by intestinal stem cells [ISCs] and adenomas) affects intestinal homeostasis, regeneration, and adenoma formation in mini-gut organoids and mice.


    Date de mise en ligne : Vendredi 14 juillet 2017
    Gianmarco Contino, Thomas L. Vaughan, David Whiteman, Rebecca Fitzgerald
    The evolving genomic landscape of Barrett’s esophagus and esophageal adenocarcinoma
    We have recently gained unprecedented insight into genetic factors that determine risk for Barrett’s esophagus (BE) and progression to esophageal adenocarcinoma (EA). Next-generation sequencing technologies have allowed us to identify somatic mutations that initiate BE and track genetic changes during development of tumors and invasive cancer. These technologies led to identification of mechanisms of tumorigenesis that challenge the current multi-step model of progression to EA. Newer, cost-effective technologies create opportunities to rapidly translate the analysis of DNA into tools that can identify patients with BE at high risk for cancer, detect dysplastic lesions at earlier stages, and uncover mechanisms of carcinogenesis.


    Date de mise en ligne : Vendredi 14 juillet 2017
    Wanlu Cao, Kan Chen, Michiel Bolkestein, Yuebang Yin, Monique M.A. Verstegen, Marcel. J.C. Bijvelds, Wenshi Wang, Nesrin Tuysuz, Derk ten Berge, Dave Sprengers, Herold J. Metselaar, Luc J.W. van der Laan, Jaap Kwekkeboom, Ron Smits, Maikel P. Peppelenbosch, Qiuwei Pan
    Dynamics of Proliferative and Quiescent Stem Cells in Liver Homeostasis and Injury
    Adult liver stem cells are usually maintained in a quiescent/slow cycling state. However, a proliferative population, marked by leucine-rich repeat-containing G-protein coupled receptor 5 (LGR5), was recently identified as an important liver stem cell population. We aimed to investigate the dynamics and functions of proliferative and quiescent stem cells in healthy and injured livers.


    Date de mise en ligne : Vendredi 14 juillet 2017
    Jennifer M. Kolb, Roy M. Soetikno, Aarti K. Rao, Dean Fong, Robert V. Rouse, Tonya Kaltenbach
    Detection, Diagnosis and Resection of Sessile Serrated Adenomas/Polyps


    Date de mise en ligne : Jeudi 13 juillet 2017
    Vincent Verdier, Minh Dung Ngo, Richard Petit
    Unusual Cause of Dysphagia


    Date de mise en ligne : Jeudi 13 juillet 2017
    Dalbir S. Sandhu, Andrew M. Bellizzi, Rami El Abiad
    Elderly lady with upper abdominal pain and 60 pounds weight loss


    Date de mise en ligne : Jeudi 13 juillet 2017
    Brian K.P. Goh, Andrew B.E. Kwek., Wei Keat Wan.
    An unusual cause of a solid-cystic pancreatic lesion


    Date de mise en ligne : Jeudi 13 juillet 2017
    Charpentier Chloé, Kottler Diane, Fite Charlotte, Anne-Laure Pelletier, Lydia Deschamps, Vincent Descamps
    A surprising granulomatous cheilitis


    Date de mise en ligne : Jeudi 13 juillet 2017
    Tao Li, Chun-Yan Hao, Zong-Li Zhang
    Hematochezia caused by a colon disease with unusual presentation


    Date de mise en ligne : Jeudi 13 juillet 2017
    Wen-Lun Wang, I-Wei Chang, Ching-Tai Lee
    An unusual rectal mass


    Date de mise en ligne : Jeudi 13 juillet 2017
    Hyun Ho Choi, Sung Soo Kim, Ok-Ran Shin
    Asymptomatic scattered pigmented flat lesions in the esophagus


    Date de mise en ligne : Jeudi 13 juillet 2017
    Johannes Hofland, Arjun D. Koch, Wouter W. de Herder
    Melaena in a patient with a metastasized neuroendocrine tumor


    Date de mise en ligne : Jeudi 13 juillet 2017
    Shenq-Jie Wong
    A Rare but Curable Cause of Iron Deficiency Anemia


    Date de mise en ligne : Jeudi 13 juillet 2017
    Obaidullah Aseem, Daniel S. Childs, Conor G. Loftus
    Diffuse small intestine erosions and ulcers in an immunocompromised host


    Date de mise en ligne : Jeudi 13 juillet 2017
    Jana G. Hashash, Aline El-Haddad, Kassem Barada
    Acute Epigastric Abdominal Pain Post-Gastric Polypectomy


    Date de mise en ligne : Jeudi 13 juillet 2017
    Angela Dolganiuc, Peter V. Draganov, Alexander Schlachterman
    Rodeo, anyone?


    Date de mise en ligne : Mercredi 12 juillet 2017
    E.K. Hsu, M.L. Shaffer, L. Gao, C. Sonnenday, M.L. Volk, J. Bucuvalas, J.C. Lai
    Analysis of Liver Offers to Pediatric Candidates on the Transplant Wait List
    Approximately 10% of children on the liver transplant wait-list in the United States (US) die every year. We examined deceased donor liver offer acceptance patterns and their contribution to pediatric wait-list mortality.


    Date de mise en ligne : Mercredi 12 juillet 2017
    Graham M. Snyder, Sharon B. Wright, Anne Smithey, Meir Mizrahi, Michelle Sheppard, Elizabeth B. Hirsch, Ram Chuttani, Riley Heroux, David S. Yassa, Lovisa B. Olafsdottir, Roger B. Davis, Anastasiou Jiannis, Vijay Bapat, Kiran Bidari, Douglas K. Pleskow, Daniel Leffler, Benjamin Lane, Alice Chen, Howard S. Gold, Anthony Bartley, Aleah D. King, Mandeep S. Sawhney
    Randomized Comparison of 3 High-level Disinfection and Sterilization Procedures for Duodenoscopes
    The DISINFECTS trial is a prospective randomized trial investigating three methods of reprocessing duodenoscopes: standard high-level disinfection with ortho-phthalaldehyde disinfectant, standard high-level disinfection with a repeated (double) cycle of disinfectant exposure, and standard high-level disinfection followed by ethylene oxide gas sterilization. No significant difference was noted between these reprocessing methods with regard to proportion of duodenoscopes with MDRO contamination, or demonstrating ≄10 CFU or >0 CFU growth of any aerobic bacteria.


    Date de mise en ligne : Mercredi 12 juillet 2017
    Olga Bednarska, Susanna A. Walter, Maite Casado-Bedmar, Magnus Ström, EloĂ­sa Salvo-Romero, Maria Vicario, Emeran A. Mayer, Åsa V. Keita
    Vasoactive Intestinal Polypeptide and Mast Cells Regulate Increased Passage of Colonic Bacteria in Patients With Irritable Bowel Syndrome
    Irritable bowel syndrome (IBS) is associated with intestinal dysbiosis and symptoms of IBS develop following gastroenteritis. We aimed to study passage of live bacteria through the colonic epithelium, and determine the role of mast cells and vasoactive intestinal polypeptide (VIP) in barrier regulation in IBS and healthy individuals.


    Date de mise en ligne : Mercredi 12 juillet 2017
    Meenakshi Rao, Daniella Rastelli, Lauren Dong, Sophia Chiu, Wanda Setlik, Michael D. Gershon, Gabriel Corfas
    Enteric Glia Regulate Gastrointestinal Motility but are not Required for Maintenance of the Epithelium in Mice
    When the glial fibrillary acidic protein (GFAP) promoter is used to express cellular toxins that eliminate glia in mice, intestinal epithelial permeability and proliferation increase; this led to the concept that glia are required for maintenance of the gastrointestinal epithelium. Many enteric glia, however, particularly in the mucosa, do not express GFAP. In contrast, virtually all enteric glia express proteolipid protein 1 (PLP1). We investigated whether elimination of PLP1-expressing cells compromises epithelial maintenance or gastrointestinal motility.


    Date de mise en ligne : Mercredi 12 juillet 2017
    Ming-Whei Yu, Chih-Lin Lin, Chun-Jen Liu, Shu-Han Yang, Yu-Lin Tseng, Chih-Feng Wu
    Influence of Metabolic Risk Factors on Risk of Hepatocellular Carcinoma and Liver-related Death in Men with Chronic Hepatitis B: A Large Cohort Study
    Little is known about the absolute risk of hepatocellular carcinoma (HCC) and liver-disease related death, in association with metabolic risk factors, for patients with hepatitis B virus (HBV) infection.


    Date de mise en ligne : Vendredi 07 juillet 2017
    Fady G. Haddad, Sandy El Bitar, Liliane Deeb
    Growing in Silence!


    Date de mise en ligne : Mardi 04 juillet 2017
    Mila Hyytinen, Erkki Savilahti, Suvi M. Virtanen, Taina HĂ€rkönen, Jorma Ilonen, Kristiina LuopajĂ€rvi, Raivo Uibo, Outi Vaarala, Hans K. Åkerblom, Mikael Knip, Finnish TRIGR Pilot Study Group
    Avoidance of Cow's Milk-based Formula for At-risk Infants Does Not Reduce Development of Celiac Disease: a Randomized Controlled Trial
    Feeding during first months of life might affect risk of celiac disease. Individuals with celiac disease or type 1 diabetes have been reported to have high titers of antibodies against cow®s milk proteins. Avoidance of cow’s milk-based formula for infants with genetic susceptibility for type 1 diabetes reduced the cumulative incidence of diabetes-associated autoantibodies. We performed a randomized controlled trial, in the same population, to study whether weaning to an extensively hydrolyzed formula reduced the risk of celiac disease autoimmunity or celiac disease.


    Date de mise en ligne : Lundi 03 juillet 2017
    Marianna Parlato, Fabienne Charbit-Henrion, Patti Hayes, Antonio Tiberti, Marina Aloi, Salvatore Cucchiara, Bernadette BĂšgue, Marc Bras, Aurore Pouliet, Sabine Rakotobe, Frank Ruemmele, Ulla G. Knaus, Nadine Cerf-Bensussan
    First Identification of Biallelic Inherited DUOX2 Inactivating Mutations as a Cause of Very Early Onset Inflammatory Bowel Disease
    By catalyzing generation of hydrogen peroxide (H202) in enterocytes, DUOX2 participates in innate defense against intestinal microbes.1,2 One monoallelic exonic variant of DUOX2 was recently found in 15 out of 19 Crohn disease-affected patients in a large Ashkenazi family.3 Herein, we report the first identification of biallelic, inherited mutations of DUOX2 as a Mendelian cause of very early onset inflammatory bowel disease (VEO-IBD) in a boy born from unrelated parents of Italian origin. The patient developed pancolitis with bloody diarrhea at the age of 3.


    Date de mise en ligne : Samedi 01 juillet 2017
    Andrew T. Chan, Christopher S. Williams
    Covering the Cover
    In an analysis of data from a pilot screening program, 23% of colorectal cancers diagnosed after fecal immunochemical testing were interval cancers.


    Date de mise en ligne : Samedi 01 juillet 2017
    Jung Wan Choe, Jong Jin Hyun
    The Eye of a Stranger
    Question: A 48-year-old woman was referred to the department of gastroenterology for evaluation of a tracheoesophageal (TE) fistula. She was a diabetic and hypertensive with a history of having suffered from myocardial infarction 5 years ago. The patient had undergone craniectomy for decompression of traumatic subdural hematoma after having fallen down a flight of stairs about a month ago. There were no complications after the operation, but because her self-respiration was weak, a tracheostomy was performed to continue respiratory support.


    Date de mise en ligne : Vendredi 30 juin 2017
    Carmelo Scarpignato, Angel Lanas, Ingvar Bjarnason
    Reply
    We thank Dr Zhang for his interest in our paper.1 We disagree, however, with the points raised. Before giving a point-to-point comment to his statements, we would like to emphasize that—as stated on page 981 of the publication—our work was a proof-of-concept study with the aims and limitations of such a kind of trial.


    Date de mise en ligne : Vendredi 30 juin 2017
    Roos E. Pouw, Jacques J. Bergman
    Safety Signal for the Simple Double Ablation Regimen When Using the Barrx 360 Express Radiofrequency Ablation Balloon Catheter
    As principal investigators of an ongoing randomized study evaluating different ablation regimens for the Barrx 360 express RFA balloon catheter (360 Express; GI solutions Covidien/Medtronic, Sunnyvale, CA), we feel the responsibility to communicate our interim finding of an unexpected high rate of severe esophageal stenosis when using the 360 Express with a simplified 2 × 10 J/cm2 no clean ablation regimen.


    Date de mise en ligne : Vendredi 30 juin 2017
    Yosuke Toya, Makoto Eizuka, Takayuki Matsumoto
    Submucosal Tumor of the Stomach With Drastic, Short-term Changes in Morphology
    Question: A 47-year-old man was referred to our institution for detailed examination of gastric tumor. One year previously, the patient was diagnosed as having a submucosal tumor in the upper gastric corpus by screening esophagogastroduodenoscopy (Figure A). On admission, laboratory tests were within normal limits and Helicobacter pylori was negative as determined by the stool antigen test and the serological test. Esophagogastroduodenoscopy revealed that the lesion had increased in size with ulceration (Figure B).


    Date de mise en ligne : Vendredi 30 juin 2017
    Hsu-Heng Yen, Kuo-Hua Lin, Chih-Jung Chen
    An Unusual Cause of Obscure Gastrointestinal Bleeding
    Question: A 54-year-old man was referred to our hospital with a 1-month history of intermittent tarry to bloody stool. His medical history included hepatitis B–related liver cirrhosis and hepatocellular carcinoma (HCC). His hepatoma was diagnosed 1 year earlier (American Joint Committee on Cancer Staging T3aN0M0) , and he was treated with radiofrequency ablation and tumor embolization. The tumor recently progressed with portal vein tumor thrombosis (Figure A). He underwent sorafenib therapy; however, the drug was discontinued after the bleeding episode.


    Date de mise en ligne : Vendredi 30 juin 2017
    Baocheng Deng, Wei Cui, Pei Liu
    A Man With Intermittent Abdominal Pain, Liver Injury, and Renal Impairment
    Question: A 45-year-old man presented with intermittent abdominal pain, dark urine, and constipation for 6 months. Laboratory tests of the initial episode showed total bilirubin 109.9 ÎŒmol/L (reference range, 3.4-20.5), alanine aminotransferase 3500 U/L (reference range, 9-40), aspartate aminotransferase 1860 U/L (reference range, 15-40), gamma-glutamyl transferase 763 U/L (reference range, 10-60), and alkaline phosphatase 164 U/L (reference range, 45-125). The patient was discharged with abnormal liver biochemistry.


    Date de mise en ligne : Vendredi 30 juin 2017
    Saeed Ali, Asad ur Rahman, Udayakumar Navaneethan
    An Unusual Cause of Recurrent Gastrointestinal Bleeding After Whipple’s Surgery
    Question: A 55-year-old Caucasian woman was admitted to the hospital with recurrent melena and hematochezia. Her past medical history was significant for a well-differentiated neuroendocrine tumor of the head of the pancreas for which she had undergone Whipple’s procedure 10 years ago. Her postoperative course was complicated by portal vein thrombosis. She also had a history of compensated liver cirrhosis secondary to nonalcoholic fatty liver disease. She was extensively evaluated in the past 2 years for recurrent gastrointestinal (GI) bleeding with upper and lower endoscopy, double balloon enteroscopy, video capsule endoscopy, and angiography.


    Date de mise en ligne : Vendredi 30 juin 2017
    Nazar Hafiz, Kevin G. Greene, Seth D. Crockett
    An Unusual Cause of Right Upper Quadrant Pain
    Question: A 32-year-old man with a 2-year history of pain localized to the right upper quadrant was referred to our clinic for evaluation. Pain was reported as dull and constant that was exacerbated by eating. He also reported occasional nausea and vomiting, especially with severe pain. In addition, he reported diarrhea, having 5-6 bowel movements per day that were loose in consistency. He denied blood in stools.


    Date de mise en ligne : Jeudi 29 juin 2017
    Exam 3: Effects of Anticoagulants in Patients With Cirrhosis and Portal Vein Thrombosis: A Systematic Review and Meta-analysis


    Date de mise en ligne : Jeudi 29 juin 2017
    Exam 2: Longer Observation Time Increases Proportion of Neoplasms Detected by Esophagogastroduodenoscopy


    Date de mise en ligne : Jeudi 29 juin 2017
    Exam 1: Endoscopic Ultrasound Imaging Detection of Gastric Cancer in Familial Adenomatous Polyposis


    Date de mise en ligne : Jeudi 29 juin 2017
    Gerard E. Mullin

    Medical nutrition is an area that is underrepresented in medical school curricula and is not emphasized on national board examinations creating knowledge gaps in hospital-based practices.1 Malnutrition occurs in one-third to one-half of all adult patients admitted to the hospital and one-third of normally nourished adults become malnourished during their hospitalization.2 Malnutrition has been linked to an increased duration of hospital stay, higher rates of 30-day readmissions, and adverse health outcomes by imparting $15.5 billion in direct medical costs in the United States.


    Date de mise en ligne : Jeudi 29 juin 2017
    Zhi-Feng Zhang
    Rifaximin in Prevention of Intestinal Lesions Associated With Nonsteroidal Anti-Inflammatory Drugs: Good Idea Needing Confirmation
    I read with great interest the article by Scarpignato et al1 evaluating the efficacy of rifaximin in preventing intestinal lesions associated with nonsteroidal anti-inflammatory drugs (NSAIDs). The authors declare that rifaximin is effective in preventing the occurrence of NSAID-induced intestinal lesions and that intestinal bacteria contribute to the development of NSAID-associated enteropathy.1 Intestinal mucosal injury is very common in NSAID users,2 and effective treatment for NSAID-associated enteropathy is lacking to date.


    Date de mise en ligne : Jeudi 29 juin 2017
    Bryan F. Curtin, Sonia Abichandani, Erik C. von Rosenvinge
    Toasted: The Perils of Home Remedy
    Question: A 55-year-old man with a history of chronic back pain decided to wean himself off of long-standing high-dose opiates. As he self-titrated down his opiate dose, he developed increasingly severe abdominal pain. To alleviate this pain, he applied a heating pad to his abdomen on a daily basis, a practice that he continued for a 6-month period. He presented to our clinic for evaluation of his abdominal pain and reported that the heating pad helped to ease his pain, but that he had progressively developed a rash over his abdomen.


    Date de mise en ligne : Jeudi 29 juin 2017
    Angela Dolganiuc, Xiuli Liu, Anil Sharma
    A Rarissime Case of Abnormally Appearing Appendix
    Question: A 68-year-old woman presented for screening colonoscopy. She stated no fever or chills and denied any pain, including abdominal pain, overt gastrointestinal bleeding, or change in bowel habits. The patient did not have chronic medical conditions and took no medications. Her weight had remained stable over the last several years with a diet limited in carbohydrates and moderately strenuous exercise. Her family history was negative for any cancer, including colon cancer, or inflammatory bowel disease.


    Date de mise en ligne : Jeudi 29 juin 2017
    Polychronis Pavlidis, Hadil Abu Arqoub, Bu’Hussain Hayee
    Gastric Lesion in a Patient With Lynch Syndrome
    Question: An asymptomatic, 67-year-old woman was referred for esophagogastroduodenoscopy (EGD) and ileocolonoscopy in view of her diagnosis of Lynch syndrome (LS). The EGD revealed generalized erythema of the gastric mucosa and a urease test was positive. While withdrawing the endoscope, the shown lesion, measuring approximately 3 × 5mm (Figure A, white light imaging), was identified at the middle of the gastric body and multiple biopsies were taken (Figure B, stain: hematoxylin and eosin; C, magnification).


    Date de mise en ligne : Jeudi 29 juin 2017
    Dhyanesh A. Patel, William E. Gibson, Michael F. Vaezi
    Achalasia: It’s Not All About the Lower Esophageal Sphincter
    Question: A 66-year-old man with cirrhosis secondary to hepatitis C (complicated with development of esophageal varices) and achalasia (diagnosed in 1980s, failed Botox injections, pneumatic dilatation, calcium channel blockers, and now status post percutaneous endoscopic gastrostomy tube placement for feedings) presented as a referral for evaluation and management of achalasia. He was deemed to be a very high-risk surgical myotomy candidate owing to cirrhosis and signs of portal hypotension (platelets of 55,000 and International Normalized Ratio of 1.4).


    Date de mise en ligne : Mercredi 28 juin 2017
    Ted Walker, Matthew Ciorba, Erik R. Dubberke
    Reducing Fluoroquinolone Use Is a Key Step in Controlling the Burden of Clostridium difficile Infection
    Dingle KE, Didelot X, Quan TP, et al. Effects of control interventions on Clostridium difficile infection in England: an observational study. The Lancet Infectious Diseases 2017; 17: 411–421.


    Date de mise en ligne : Lundi 26 juin 2017
    Hamish Philpott, Evan S. Dellon
    A Penetrating Look at Eosinophilic Esophagitis Pathogenesis: Direct Antigen Exposure in the Esophagus?
    Marietta EV, Geno DM, Smyrk TC, et al. Presence of intraepithelial food antigen in patients with active eosinophilic oesophagitis. Aliment Pharmacol Ther 2017;45:427–433.


    Date de mise en ligne : Lundi 26 juin 2017
    Silvio Danese, Gionata Fiorino, Laurent Peyrin-Biroulet
    Filgotinib in Crohn’s Disease: JAK Is Back
    Vermeire S, Schreiber S, Petryka R, et al. Clinical remission in patients with moderate-to-severe Crohn's disease treated with filgotinib (the FITZROY study): results from a phase 2, double-blind, randomised, placebo-controlled trial. Lancet 2017;389:266–275.


    Date de mise en ligne : Lundi 26 juin 2017
    Sean M. Ward
    Hyperplasia of Interstitial Cells of Cajal Leads to Rapid Gastric Emptying in Diabetes
    Coordinated contractions of the stomach are integrated motor responses classically described as consisting of “neurogenic” and “myogenic” components. In the last 2 decades, dissection of the myogenic elements using genetic, molecular, morphologic, and physiologic approaches have identified several cells types that contribute to this component of gastrointestinal (GI) motility. Interstitial cells of Cajal (ICC) are recognized as major contributors to GI motor activity.1 These cells are gastric pacemakers and act as neuroeffectors between enteric motor nerve terminals and smooth muscle cells (SMC).


    Date de mise en ligne : Jeudi 22 juin 2017
    Guoying Zhou, Dave Sprengers, Patrick P.C. Boor, Michail Doukas, Hannah Schutz, Shanta Mancham, Alexander Pedroza-Gonzalez, Wojciech G. Polak, Jeroen de Jonge, Marcia Gaspersz, Haidong Dong, Kris Thielemans, Qiuwei Pan, Jan N.M. IJzermans, Marco J. Bruno, Jaap Kwekkeboom
    Antibodies Against Immune Checkpoint Molecules Restore Functions of Tumor-infiltrating T cells in Hepatocellular Carcinomas
    Ligand binding to inhibitory receptors on immune cells, such as programmed cell death 1 (PD-1) and cytotoxic T-lymphocyte associated protein 4 (CTLA4), downregulates the T-cell–mediated immune response (called immune checkpoints). Antibodies that block these receptors increase anti-tumor immunity in patients with melanoma, non-small cell lung cancer, and renal cell cancer. Tumor-infiltrating CD4+ and CD8+ T cells in patients with hepatocellular carcinoma (HCC) have been found to be functionally compromised.


    Date de mise en ligne : Mercredi 21 juin 2017
    Herbert Tilg
    How to Approach a Patient With Nonalcoholic Fatty Liver Disease
    Nonalcoholic fatty liver disease (NAFLD) has evolved as the most common liver disease worldwide. NAFLD covers a disease spectrum, ranging from simple steatosis in the absence of inflammation to nonalcoholic steatohepatitis (NASH), liver cirrhosis, and hepatocellular carcinoma (HCC). The prevalence of NAFLD is high and might reach up to 30% in certain populations such as US Americans or Asians, mostly paralleling rates of obesity and type 2 diabetes (T2D).1 The number of patients with NAFLD that have NASH is unclear, but is >10% of the overall NAFLD population.


    Date de mise en ligne : Mercredi 21 juin 2017
    Patrick S. Yachimski, Andrew Ross
    The Future of Endoscopic Retrograde Cholangiopancreatography
    Peroral cannulation of the bile duct and pancreatic duct under fluoroscopic guidance was first reported in 19651 and endoscopic visualization and cannulation of the ampulla of Vater in a series of nearly 50 patients, with a technical success rate of 25%, was reported in 1968.2 With the development of dedicated duodenoscopes as well as endoscopic techniques and tools necessary for therapeutic intervention, endoscopic retrograde cholangiopancreatography (ERCP) has, within the course of the past half century, assumed a major role in the management of pancreaticobiliary disease.


    Date de mise en ligne : Mercredi 21 juin 2017
    Michael B. Wallace, Kenneth K. Wang, Douglas G. Adler, Amit Rastogi
    Recent Advances in Endoscopy
    In this narrative review, invited by the Editors of Gastroenterology, we summarize recent advances in the field of gastrointestinal endoscopy. We have chosen articles published primarily in the past 2−3 years. Although a thorough literature review was performed for each topic, the nature of the article is subjective and systematic and is based on the authors’ experience and expertise regarding articles we believed were most likely to be of high clinical and scientific importance.


    Date de mise en ligne : Lundi 19 juin 2017
    Tom Holvoet, Sarah Devriese, Karolien Castermans, Sandro Boland, Dirk Leysen, Yves-Paul Vandewynckel, Lindsey Devisscher, Lien Van den Bossche, Sophie Van Welden, Melissa Dullaers, Roosmarijn E. Vandenbroucke, Riet De Rycke, Karel Geboes, Arnaud Bourin, Olivier Defert, Pieter Hindryckx, Martine De Vos, Debby Laukens
    Treatment of intestinal fibrosis in experimental inflammatory bowel disease by the pleiotropic actions of a local Rho kinase inhibitor
    Intestinal fibrosis resulting in (sub)obstruction is a common complication of Crohn’s disease (CD). Rho kinases (ROCKs) play multiple roles in TGFÎČ1-induced myofibroblast activation that could be therapeutic targets. Because systemic ROCK inhibition causes cardiovascular side-effects, we evaluated the effects of a locally acting ROCK inhibitor (AMA0825) on intestinal fibrosis.


    Date de mise en ligne : Lundi 19 juin 2017
    Fasiha Kanwal, Jennifer Kramer, Steven M. Asch, Maneerat Chayanupatkul, Yumei Cao, Hashem B. El-Serag
    Risk of Hepatocellular Cancer in HCV Patients Treated with Direct Acting Antiviral Agents
    The risk of hepatocellular cancer (HCC) after sustained virological response (SVR) with direct acting antivirals (DAA) is unclear. Our aim was to examine the risk and determinants of HCC in patients cured with DAA.


    Date de mise en ligne : Samedi 17 juin 2017
    Mei Zeng, Mitchell Szymczak, Malini Ahuja, Changyu Zheng, Hongen Yin, William Swaim, John A. Chiorini, Robert J. Bridges, Shmuel Muallem
    Pharmacological Rescue of Ductal CFTR Rescue Pancreatic and Salivary glands Acinar Cells and Tissue Function in Mouse Models of Autoimmune diseases
    Sjögren’s syndrome and autoimmune pancreatitis (AIP) are disorders with decreased function of salivary, lacrimal glands, and the exocrine pancreas. NOD/ShiLTJ mice and mice transduced with the cytokine BMP6 develop Sjögren’s syndrome and chronic pancreatitis and MRL/Mp mice are models of AIP. CFTR is a ductal Cl- channel essential for ductal fluid and HCO3- secretion. We used these models to ask: is CFTR expression altered in these diseases, does correction of CFTR correct gland function, and most notably, does correcting ductal function correct acinar function.


    Date de mise en ligne : Jeudi 15 juin 2017
    H.M. Staudacher, M.C.E. Lomer, F.M. Farquharson, P. Louis, F. Fava, E. Franciosi, M. Scholz, K.M. Tuohy, J.O. Lindsay, P.M. Irving, K. Whelan
    Diet Low in FODMAPs Reduces Symptoms in Patients with Irritable Bowel Syndrome and Probiotic Restores Bifidobacterium Species: a Randomized Controlled Trial
    Dietary restriction of fermentable carbohydrates (a low FODMAP diet) has been reported to reduce symptoms in some patients with irritable bowel syndrome (IBS). We performed a randomized, placebo-controlled study to determine its effects on symptoms and the fecal microbiota in patients with IBS.


    Date de mise en ligne : Jeudi 15 juin 2017
    G. Jobin, R. Rodriguez-Suarez, K. Betito
    Association Between Natural Killer Cell Activity and Colorectal Cancer in High-risk Subjects Undergoing Colonoscopy
    Low activity of natural killer (NK) cells has been associated with increased risk of cancer and has been reported in patients with colorectal cancer (CRC). Activity of NK cells can be measured in a small volume of whole blood by a commercially available test. We investigated whether this test could be used to identify patients with CRC, using findings from colonoscopy as a reference standard.


    Date de mise en ligne : Jeudi 15 juin 2017
    Jing Wang, Dmitri Mouradov, Xiaojing Wang, Robert N. Jorissen, Matthew C. Chambers, Lisa J. Zimmerman, Suhas Vasaikar, Christopher G. Love, Shan Li, Kym Lowes, Karl-Johan Leuchowius, Helene Jousset, Janet Weinstock, Christopher Yau, John Mariadason, Zhiao Shi, Yuguan Ban, Xi Chen, Robert J.C. Coffey, Robbert J.C. Slebos, Antony W. Burgess, Daniel C. Liebler, Bing Zhang, Oliver M. Sieber
    Colorectal cancer cell line proteomes are representative of primary tumors and predict drug sensitivity
    Proteomics holds promise for individualizing cancer treatment. We analyzed to what extent the proteomic landscape of human colorectal cancer (CRC) is maintained in established CRC cell lines and the utility of proteomics for predicting therapeutic responses.


    Date de mise en ligne : Mercredi 14 juin 2017
    Daniela Sia, Yang Jiao, Iris Martinez-Quetglas, Olga Kuchuk, Carlos Villacorta-Martin, Manuel Castro de Moura, Juan Putra, Genis Camprecios, Laia Bassaganyas, Nicholas Akers, Bojan Losic, Samuel Waxman, Swan N. Thung, Vincenzo Mazzaferro, Manel Esteller, Scott L. Friedman, Myron Schwartz, Augusto Villanueva, Josep M. Llovet
    Identification of an Immune-specific Class of Hepatocellular Carcinoma, Based on Molecular Features
    The study defines the ∌25% population with molecular characteristics - including high infiltration of immune cells, expression of PD-1 and CD274 molecule (PD-L1), and active IFN-Îł signaling - that highly resemble those of cancers most responsive to immunotherapy.


    Date de mise en ligne : Mercredi 14 juin 2017
    Annick Vanclooster, Cees van Deursen, Reggy Jaspers, David Cassiman, Ger Koek
    Proton pump inhibitors decrease phlebotomy need in HFE hemochromatosis: double-blind randomized placebo-controlled trial


    Date de mise en ligne : Mercredi 14 juin 2017
    Michael S. Middleton, Elhamy R. Heba, Catherine A. Hooker, Mustafa R. Bashir, Kathryn J. Fowler, Kumar Sandrasegaran, Elizabeth M. Brunt, David E. Kleiner, Edward Doo, Mark L. Van Natta, James Tonascia, Joel E. Lavine, Brent A. Neuschwander-Tetri, Arun Sanyal, Rohit Loomba, Claude B. Sirlin, NASH Clinical Research Network
    Agreement Between Magnetic Resonance Imaging Proton Density Fat Fraction Measurements and Pathologist-assigned Steatosis Grades of Liver Biopsies from Adults with Nonalcoholic Steatohepatitis
    We assessed the diagnostic performance of magnetic resonance imaging (MRI) proton density fat fraction (PDFF) in grading hepatic steatosis and change in hepatic steatosis in adults with nonalcoholic steatohepatitis (NASH) in a multi-center study, using central histology as reference.


    Date de mise en ligne : Mercredi 14 juin 2017
    Sara Botschuijver, Guus Roeselers, Evgeni Levin, Daisy M. Jonkers, Olaf Welting, Sigrid EM. Heinsbroek, Heleen H. de Weerd, Teun Boekhout, Matteo Fornai, Ad A. Masclee, Frank H.J. Schuren, Wouter J. de Jonge, Jurgen Seppen, Rene M. van den Wijngaard.
    Intestinal Fungal Dysbiosis Associates With Visceral Hypersensitivity in Patients With Irritable Bowel Syndrome and Rats
    Visceral hypersensitivity is one feature of irritable bowel syndrome (IBS). Bacterial dysbiosis might be involved in activation of nociceptive sensory pathways, but there have been few studies of the role of the mycobiome (the fungal microbiome) in development of IBS. We analyzed intestinal mycobiomes of patients with IBS and a rat model of visceral hypersensitivity.


    Date de mise en ligne : Mercredi 14 juin 2017
    Jana Nano, Mohsen Ghanbari, Wenshi Wang, Paul S. de Vries, Klodian Dhana, Taulant Muka, André G. Uitterlinden, Joyce B.J. van Meurs, Albert Hofman, BIOS consortium, Oscar H. Franco, Qiuwei Pan, Sarwa Darwish Murad, Abbas Dehghan
    Epigenome-wide Association Study Identifies Methylation Sites Associated With Liver Enzymes and Hepatic Steatosis
    Epigenetic mechanisms might be involved in the regulation of liver enzyme level. We aimed to identify CpG sites at which DNA methylation levels are associated with blood levels of liver enzymes and hepatic steatosis.


    Date de mise en ligne : Mercredi 14 juin 2017
    K.J. Werkstetter, I.R. Korponay-SzabĂł, A. Popp, V. Villanacci, M. Salemme, G. Heilig, S.T. Lillevang, M.L. Mearin, C. Ribes-Koninckx, A. Thomas, R. Troncone, B. Filipiak, M. MĂ€ki, J. Gyimesi, M. Najafi, J. DolinĆĄek, S. Dydensborg Sander, R. Auricchio, A. Papadopoulou, A. VĂ©csei, P. Szitanyi, E. Donat, R. Nenna, Ph. Alliet, F. Penagini, H. Garnier-LenglinĂ©, G. Castillejo, K. Kurppa, R. Shamir, A.C. Hauer, F. Smets, S. Corujeira, M. van Winckel, S. Buderus, S. Chong, S. Husby, S. Koletzko, ProCeDE study group, Piotr Socha, Bozena Cukrowska, Hania Szajewska, Jan Wyhowski, Nailah Brown, Gauri Batra, Zrinjka Misak, Sven Seiwerth, Yulia Dmitrieva, Dmitry Abramov, Yvan Vandenplas, Annieta Goossens, Maaike W. Schaart, V.T.H.B.M. Smit, Nicolas Kalach, Pierre Gosset, Judit B. KovĂĄcs, AnikĂł Nagy, Ilona Lellei, Rita KƑbĂĄnyai, Katayoun Khatami, Maryam Monajemzadeh, Konstantina Dimakou, Amalia Patereli, Tine Plato Hansen, Rajko Kavalar, Miguel Bolonio, Hubert Kogler, Gabriele Amann, Roberta Kosova, Mariantonia Maglio, Elke Janssens, Ruth Achten, Pavel FrƱhauf, Helena SkĂĄlovĂĄ, Thomas Kirchner, Laura Petrarca, Fabio Massimo Magliocca, Francesc MartĂ­nez, Vanesa Morente, Sonja Thanner-Lechner, Manfred Ratschek, Marco Gasparetto, Liz Hook, Danielle Canioni, Catherine Wanty, Anne Mourin, Kaija Laurila, Martine Vornane, Vered Nachmias Friedler, Sara L. Morgenstern, Jorge Amil Dias, FĂĄtima Carneiro, Stephanie Van Biervliet, Saskia Vande Velde, Hany Banoub, Steve Sampson, Annette M. MĂŒller, Adina Ene, Mandana Rafeey, Iran Amir Taher Eftekhar Sadat
    Accuracy in Diagnosis of Celiac Disease Without Biopsies in Clinical Practice
    The guidelines of the European Society of Pediatric Gastroenterology, Hepatology, and Nutrition allow for diagnosis of celiac disease without biopsies in children with symptoms and levels of immunoglobulin A against tissue-transglutaminase (TGA-IgA) 10-fold or more the upper limit of normal (ULN), confirmed by detection of endomysium antibodies (EMA) and positivity for HLA-DQ2/DQ8. We performed a large, international prospective study to validate this approach.


    Date de mise en ligne : Mercredi 07 juin 2017
    Gautam Mankaney, Carol A. Burke, Michael Cruise, James Church, Vaibhav Wadhwa, Prabhleen Chahal, John Vargo, Amit Bhatt
    Endoscopic Ultrasound Imaging Detection of Gastric Cancer in Familial Adenomatous Polyposis
    Familial adenomatous polyposis (FAP) is a hereditary colorectal cancer syndrome characterized by the autosomal dominant inheritance of colorectal polyps and colorectal cancer. Since the advent of presymptomatic diagnosis and use of prophylactic colectomy, the incidence of colorectal cancer has decreased, and foregut malignancies are more frequently encountered. We have observed a sudden increase in the incidence of gastric cancer in FAP patients enrolled in our hereditary cancer registry. Comparing our population with the Surveillance, Epidemiology, and End Results database for gastric cancer, the standardized incidence ratio is 140.


    Date de mise en ligne : Mercredi 07 juin 2017
    Jeff Chang, Rupert W. Leong, Valerie Wasinger, Matthew Ip, Michael Yang, Tri Giang Phan
    Impaired Intestinal Permeability Contributes to Ongoing Bowel Symptoms in Patients With Inflammatory Bowel Disease and Mucosal Healing
    Many patients with inflammatory bowel diseases (IBD) have ongoing bowel symptoms of diarrhea or abdominal pain despite mucosal healing. We investigated whether impaired intestinal permeability contributes to these symptoms.


    Date de mise en ligne : Lundi 05 juin 2017
    Alissa C. Nicolucci, Megan P. Hume, Inés Martínez, Shyamchand Mayengbam, Jens Walter, Raylene A. Reimer
    Prebiotic Reduces Body Fat and Alters Intestinal Microbiota in Children With Overweight or Obesity
    It might be possible to manipulate the intestinal microbiota with prebiotics or other agents to prevent or treat obesity. However, little is known about the ability of prebiotics to specifically modify gut microbiota in children with overweight/obesity or reduce body weight. We performed a randomized controlled trial to study the effects of prebiotics on body composition, markers of inflammation, bile acids in fecal samples, and composition of the intestinal microbiota in children with overweight or obesity.


    Date de mise en ligne : Vendredi 02 juin 2017
    Robert J. Huang, Monique T. Barakat, Mohit Girotra, Subhas Banerjee
    Practice Patterns for Cholecystectomy Following Endoscopic Retrograde Cholangio-Pancreatography for Patients With Choledocholithiasis
    Cholecystectomy (CCY) following an episode of choledocholithiasis requiring endoscopic retrograde cholangio-pancreatography (ERCP) with stone extraction reduces recurrent biliary events, compared to expectant management. We studied practice patterns for performance of CCY following ERCP for choledocholithiasis using data from 3 large states and evaluated the effects of delaying CCY.


    Date de mise en ligne : Vendredi 02 juin 2017
    Nicholas G. Burgess, Luke F. Hourigan, Simon A Zanati, Gregor J. Brown, Rajvinder Singh, Stephen J. Williams, Spiro C. Raftopoulos, Donald Ormonde, Alan Moss, Karen Byth, Hema Mahajan, Duncan McLeod, Michael J. Bourke
    Risk Stratification for Covert Invasive Cancer Among Patients Referred for Colonic Endoscopic Mucosal Resection: A Large Multicenter Cohort
    Among patients with large colorectal sessile polyps or laterally spreading lesions, it is important to identify those at risk for submucosal invasive cancer (SMIC). Lesions with overt endoscopic evidence of SMIC are referred for surgery, although those without these features might still contain SMIC that is not visible on endoscopic inspection (covert SMIC). Lesions with a high covert SMIC risk might be better suited for endoscopic submucosal dissection than for endoscopic mucosal resection (EMR).


    Date de mise en ligne : Vendredi 02 juin 2017
    Derk C.F. Klatte, Alessandro Gasparini, Hong Xu, Pietro de Deco, Marco Trevisan, Anna L.V. Johansson, Björn Wettermark, Johan Ärnlöv, Cynthia J. Janmaat, Bengt Lindholm, Friedo W. Dekker, Josef Coresh, Morgan E. Grams, Juan J. Carrero
    Association Between Proton Pump Inhibitor Use and Risk of Progression of Chronic Kidney Disease
    Proton pump inhibitors (PPI) have been associated with acute kidney injury (AKI) and recent studies suggest that they may be associated with the risk of chronic kidney disease (CKD).


    Date de mise en ligne : Vendredi 02 juin 2017
    Haojie Jin, Cun Wang, Guangzhi Jin, Haoyu Ruan, Dishui Gu, Lin Wei, Hui Wang, Ning Wang, Einthavy Arunachalam, Yurong Zhang, Xuan Deng, Chen Yang, Yi Xiong, Hugang Feng, Ming Yao, Jingyuan Fang, Jianren Gu, Wenming Cong, Wenxin Qin
    Regulator of Calcineurin 1 Gene Isoform 4, Down-regulated in Hepatocellular Carcinoma, Prevents Proliferation, Migration, and Invasive Activity of Cancer Cells and Growth of Orthotopic Tumors by Inhibiting Nuclear Translocation of NFAT1
    Individuals with Down syndrome have a low risk for many solid tumors, prompting the search for tumor suppressor genes on human chromosome 21 (HSA21). We aimed to identify and explore potential mechanisms of suppressors on HSA21 in hepatocellular carcinoma (HCC).


    Date de mise en ligne : Jeudi 01 juin 2017
    Cary C. Cotton, W. Asher Wolf, Bergein F. Overholt, Nan Li, Charles J. Lightdale, Herbert C. Wolfsen, Sarina Pasricha, Kenneth K. Wang, Nicholas J. Shaheen, AIM Dysplasia Trial Group
    Late Recurrence of Barrett’s Esophagus After Complete Eradication of Intestinal Metaplasia is Rare: Final Report From Ablation in Intestinal Metaplasia Containing Dysplasia Trial
    The goal of treatment for Barrett’s esophagus (BE) with dysplasia is complete eradication of intestinal metaplasia (CEIM). The long-term durability of CEIM has not been well characterized, so the frequency and duration of surveillance are unclear. We report results from a 5-year follow-up analysis of patients with BE and dysplasia treated by radiofrequency ablation (RFA) in the randomized controlled Ablation of Intestinal Metaplasia Containing Dysplasia (AIM) trial.


    Date de mise en ligne : Jeudi 01 juin 2017
    Jean-Marc Schwarz, Susan M. Noworolski, Ayca Erkin-Cakmak, Natalie J. Korn, Michael J. Wen, Viva W. Tai, Grace M. Jones, Sergiu P. Palii, Moises Velasco-Alin, Karen Pan, Bruce W. Patterson, Alejandro Gugliucci, Robert H. Lustig, Kathleen Mulligan
    Effects of Dietary Fructose Restriction on Liver Fat, De Novo Lipogenesis, and Insulin Kinetics in Children with Obesity
    Consumption of sugar is associated with obesity, type 2 diabetes mellitus, non-alcoholic fatty liver disease, and cardiovascular disease. The conversion of fructose to fat in liver (de novo lipogenesis, DNL) may be a modifiable pathogenetic pathway. We determined the effect of 9 days of isocaloric fructose restriction on DNL, liver fat, visceral fat (VAT), subcutaneous fat, and insulin kinetics in obese Latino and African American children with habitual high sugar consumption (fructose intake more than 50 g/day).


    Date de mise en ligne : Jeudi 01 juin 2017
    Rafael Oliveira Ximenes, Juliana Prelle Vieira Costa, Karen Thalyne Pereira e Silva
    Cullen's sign - not always acute pancreatitis


    Date de mise en ligne : Jeudi 25 mai 2017
    Alicia S. Wellman, Mallikarjuna R. Metukuri, Nevzat Kazgan, Xiaojiang Xu, Qing Xu, Natalie S.X. Ren, Agnieszka Czopik, Michael T. Shanahan, Ashley Kang, Willa Chen, M. Andrea Azcarate-Peril, Ajay S. Gulati, David C. Fargo, Leonard Guarente, Xiaoling Li
    Intestinal Epithelial Sirtuin 1 Regulates Intestinal Inflammation during Aging in Mice by Altering the Intestinal Microbiota
    Intestinal epithelial homeostasis is maintained by complex interactions among epithelial cells, commensal gut microorganisms, and immune cells. Disruption of this homeostasis is associated with disorders such as inflammatory bowel disease (IBD), but the mechanisms of this process are not clear. We investigated how Sirtuin 1 (SIRT1), a conserved mammalian NAD+-dependent protein deacetylase, senses environmental stress to alter intestinal integrity.


    Date de mise en ligne : Jeudi 25 mai 2017
    Lotte Bruens, Saskia I.J. Ellenbroek, Jacco van Rheenen, Hugo J. Snippert
    In vivo Imaging Reveals Existence of Crypt Fission and Fusion in Adult Mouse Intestine
    The intestinal epithelium is a repetitive sheet of crypt and villus units with stem cells at the bottom of the crypts. During postnatal development, crypts multiply via fission, generating 2 daughter crypts from 1 parental crypt. In the adult intestine, crypt fission is observed at a low frequency. Using intravital microscopy in Lgr5EGFP-Ires-CreERT2 mice, we monitored individual crypt dynamics over multiple days with single-cell resolution. We discovered the existence of crypt fusion, an almost exact reverse phenomenon of crypt fission, in which 2 crypts fuse into 1 daughter crypt.


    Date de mise en ligne : Lundi 22 mai 2017
    Jocelyn A. Silvester, Satya Kurada, Andrea Szwajcer, CiarĂĄn P. Kelly, Daniel A. Leffler, Donald R. Duerksen
    Tests for Serum Transglutaminase and Endomysial Antibodies Do Not Detect Most Patients With Celiac Disease and Persistent Villous Atrophy on Gluten-free Diets: a Meta-analysis
    Tests to measure serum endomysial antibodies (EMA) and antibodies to tissue transglutaminase (tTG) were developed to screen for celiac disease in patients consuming gluten. However, they are commonly used to monitor patients on a gluten-free diet (GFD). We conducted a meta-analysis to assess the sensitivity and specificity of tTG IgA and EMA IgA assays in identifying patients with celiac disease who have persistent villous atrophy despite a GFD.


    Date de mise en ligne : Samedi 20 mai 2017
    Melinda RĂĄki, Shiva Dahal-Koirala, Hao Yu, Ilma R. Korponay-SzabĂł, Judit Gyimesi, Gemma Castillejo, JĂžrgen Jahnsen, Shuo-Wang Qiao, Ludvig M. Sollid
    Similar Responses of Intestinal T Cells From Untreated Children and Adults With Celiac Disease to Deamidated Gluten Epitopes
    Celiac disease is a chronic small intestinal inflammatory disorder mediated by an immune response to gluten peptides in genetically susceptible individuals. Celiac disease is often diagnosed in early childhood, but some patients receive a diagnosis late in life. It is uncertain whether pediatric celiac disease is distinct from adult celiac disease. It has been proposed that gluten-reactive T cells in children recognize deamidated and native gluten epitopes, whereas T cells from adults only recognize deamidated gluten peptides.


    Date de mise en ligne : Lundi 15 mai 2017
    Soo Young Cho, Jun Won Park, Yang Liu, Young Soo Park, Ju Hee Kim, Hanna Yang, Hyejin Um, Woo Ri Ko, Byung Il Lee, Sun Young Kwon, Seung Wan Ryu, Chae Hwa Kwon, Do Youn Park, Jae-Hyuk Lee, Sang Il Lee, Kyu Sang Song, Hoon Hur, Sang-Uk Han, Heekyung Chang, Su-Jin Kim, Byung-Sik Kim, Jeong-Hwan Yook, Moon-Won Yoo, Beom-Su Kim, In-Seob Lee, Myeong-Cherl Kook, Nina Thiessen, An He, Chip Stewart, Andrew Dunford, Jaegil Kim, Juliann Shih, Gordon Saksena, Andrew D. Cherniack, Steven Schumacher, Amaro-Taylor Weiner, Mara Rosenberg, Gad Getz, Eun Gyeong Yang, Min-Hee Ryu, Adam J. Bass, Hark Kyun Kim
    Sporadic Early-Onset Diffuse Gastric Cancers Have High Frequency of Somatic CDH1 Alterations, but Low Frequency of Somatic RHOA Mutations Compared With Late-Onset Cancers
    Early-onset gastric cancer, which develops in patients younger than most gastric cancers, is usually detected at advanced stages, has diffuse histologic features, and occurs more frequently in women. We investigated somatic genomic alterations associated with the unique characteristics of sporadic diffuse gastric cancers (DGCs) from younger patients.


    Date de mise en ligne : Samedi 13 mai 2017
    Philip W. Voorneveld, Marlies S. Reimers, Esther Bastiaannet, Rutger J. Jacobs, Ronald van Eijk, Marjolein M.J. Zanders, Ron M.C. Herings, Myrthe P.P. van Herk-Sukel, Liudmila L. Kodach, Tom van Wezel, Peter J.K. Kuppen, Hans Morreau, Cornelis J.H. van de Velde, James C.H. Hardwick, Gerrit Jan Liefers
    Statin Use After Diagnosis of Colon Cancer and Patient Survival
    Statin use has been associated with a reduced incidence of colorectal cancer and might also affect survival of patients diagnosed with colon cancer. Statins are believed to inhibit Ras signaling and may also activate the bone morphogenetic protein (BMP) signaling pathway in colorectal cancer cells. We investigated the effects of statins on overall survival of patients with a diagnosis of colon cancer, and whether their effects were associated with changes in KRAS or the BMP signaling pathways.


    Date de mise en ligne : Vendredi 12 mai 2017
    Pankaj Yadav, David Ellinghaus, Gaëlle Rémy, Sandra Freitag-Wolf, Anabelle Cesaro, Frauke Degenhardt, Gabrielle Boucher, Myriam Delacre, The International IBD Genetics Consortium, Laurent Peyrin-Biroulet, Muriel Pichavant, John D. Rioux, Philippe Gosset, Andre Franke, L. Philip Schumm, Michael Krawczak, Mathias Chamaillard, Astrid Dempfle, Vibeke Andersen
    Genetic Factors Interact With Tobacco Smoke to Modify Risk for Inflammatory Bowel Disease in Humans and Mice
    The role of tobacco smoke in the etiology of inflammatory bowel disease (IBD) is unclear. We investigated interactions between genes and smoking (gene−smoking interactions) that affect risk for Crohn’s disease (CD) and ulcerative colitis (UC) in a case-only study of patients and in mouse models of IBD.


    Date de mise en ligne : Mercredi 10 mai 2017
    Jae Myung Park, Sol Mi Huo, Han Hee Lee, Bo-In Lee, Ho Jin Song, Myung-Gyu Choi
    Longer Observation Time Increases Proportion of Neoplasms Detected by Esophagogastroduodenoscopy
    Esophagogastroduodenoscopy (EGD) is commonly used to detect upper gastrointestinal (GI) neoplasms. However, there is little evidence that longer examination time increases rate of detection of upper GI neoplasia. We investigated the association between length of time spent performing a normal screening EGD and rate of neoplasm detection.


    Date de mise en ligne : Vendredi 05 mai 2017
    Manon van der Vlugt, Esmée J. Grobbee, Patrick M.M. Bossuyt, Amanda Bos, Evelien Bongers, Wolfert Spijker, Ernst J. Kuipers, Iris Lansdorp-Vogelaar, Manon C.W. Spaander, Evelien Dekker
    Interval Colorectal Cancer Incidence Among Subjects Undergoing Multiple Rounds of Fecal Immunochemical Testing
    Among subjects screened for colorectal cancer (CRC) by the guaiac fecal occult blood test, interval cancers develop in 48% to 55% of the subjects. Data are limited on how many persons screened by fecal immunochemical tests (FIT), over multiple rounds, develop interval cancers. In the Netherlands, a pilot FIT-based biennial CRC screening program was conducted between 2006 and 2014. We collected and analyzed data from the program on CRCs detected during screening (SD-CRC) and CRCs not detected within the screening program (non–SD-CRC; such as FIT interval cancers, colonoscopy interval cancers, and cancer in nonparticipants).


    Date de mise en ligne : Vendredi 05 mai 2017
    Maria Ines Pinto-Sanchez, Geoffrey B. Hall, Kathy Ghajar, Andrea Nardelli, Carolina Bolino, Jennifer T. Lau, Francois-Pierre Martin, Ornella Cominetti, Christopher Welsh, Amber Rieder, Jenna Traynor, Caitlin Gregory, Giada De Palma, Marc Pigrau, Alexander C. Ford, Joseph Macri, Bernard Berger, Gabriela Bergonzelli, Michael G. Surette, Stephen M. Collins, Paul Moayyedi, Premysl Bercik
    Probiotic Bifidobacterium longum NCC3001 Reduces Depression Scores and Alters Brain Activity: A Pilot Study in Patients With Irritable Bowel Syndrome
    Probiotics can reduce symptoms of irritable bowel syndrome (IBS), but little is known about their effects on psychiatric comorbidities. We performed a prospective study to evaluate the effects of Bifidobacterium longum NCC3001 (BL) on anxiety and depression in patients with IBS.


    Date de mise en ligne : Jeudi 04 mai 2017
    Harminder Singh, Zoann Nugent, B. Nancy Yu, Lisa M. Lix, Laura E. Targownik, Charles N. Bernstein
    Higher Incidence of Clostridium difficile Infection Among Individuals With Inflammatory Bowel Disease
    Studies of Clostridium difficile infections (CDIs) among individuals with inflammatory bowel disease (IBD) have used data from single centers or CDI administrative data codes of limited diagnostic accuracy. We determined the incidence, risk factors, and outcomes after CDI in a population-based cohort of patients with IBD and laboratory confirmation diagnoses of CDI.


    Date de mise en ligne : Jeudi 04 mai 2017
    Valeria Severino, Jean-Marc Dumonceau, Myriam Delhaye, Solange Moll, Isabelle Annessi-Ramseyer, Xavier Robin, Jean-Louis Frossard, Annarita Farina
    Extracellular Vesicles in Bile as Markers of Malignant Biliary Stenoses
    Algorithms for diagnosis of malignant common bile duct (CBD) stenoses are complex and lack accuracy. Malignant tumors secrete large numbers of extracellular vesicles (EVs) into surrounding fluids; EVs might therefore serve as biomarkers for diagnosis. We investigated whether concentrations of EVs in bile could discriminate malignant from nonmalignant CBD stenoses.


    Date de mise en ligne : Jeudi 04 mai 2017
    Lorenzo Loffredo, Daniele Pastori, Alessio Farcomeni, Francesco Violi
    Effects of Anticoagulants in Patients With Cirrhosis and Portal Vein Thrombosis: A Systematic Review and Meta-analysis
    Liver cirrhosis is complicated by bleeding from portal hypertension but also by portal vein thrombosis (PVT). PVT occurs in approximately 20% to 50% of patients with cirrhosis, and is a warning sign for poor outcome. It is a challenge to treat patients with cirrhosis using anticoagulants, because of the perception that the coexistent coagulopathy could promote bleeding. We performed a systematic review and meta-analysis to determine the effects of anticoagulant therapy in patients with cirrhosis and PVT.


    Date de mise en ligne : Jeudi 04 mai 2017
    Hiang Keat Tan, Wei Qiang Leow, Pik Eu Chang
    Ruxolitinib for the Treatment of Portal Hypertension in a Patient With Primary Myelofibrosis
    Primary myelofibrosis is a form of myeloproliferative neoplasm characterized by stem-cell derived clonal proliferation, resulting in bone marrow fibrosis, splenomegaly and extramedullary haematopoiesis, with portal hypertension (PHT) occuring in 10%–20% of patients. Here, we report a patient with primary myelofibrosis whose PHT improved significantly following treatment with ruxolitinib, thereby allowing discontinuation of all drug therapy for PHT.


    Date de mise en ligne : Vendredi 28 avril 2017
    Johannes Wolf, David Petroff, Thomas Richter, Marcus K.H. Auth, Holm H. Uhlig, Martin W. Laass, Peter Lauenstein, Andreas Krahl, Norman HĂ€ndel, Jan de Laffolie, Almuthe C. Hauer, Thomas Kehler, Gunter Flemming, Frank Schmidt, Astor Rodrigues, Dirk Hasenclever, Thomas Mothes
    Validation of Antibody-Based Strategies for Diagnosis of Pediatric Celiac Disease Without Biopsy
    A diagnosis of celiac disease is made based on clinical, genetic, serologic, and duodenal morphology features. Recent pediatric guidelines, based largely on retrospective data, propose omitting biopsy analysis for patients with concentrations of IgA against tissue transglutaminase (IgA-TTG) >10-fold the upper limit of normal (ULN) and if further criteria are met. A retrospective study concluded that measurements of IgA-TTG and total IgA, or IgA-TTG and IgG against deamidated gliadin (IgG-DGL) could identify patients with and without celiac disease.


    Date de mise en ligne : Mercredi 26 avril 2017
    James K.Y. Hooi, Wan Ying Lai, Wee Khoon Ng, Michael M.Y. Suen, Fox E. Underwood, Divine Tanyingoh, Peter Malfertheiner, David Y. Graham, Vincent W.S. Wong, Justin C.Y. Wu, Francis K.L. Chan, Joseph J.Y. Sung, Gilaad G. Kaplan, Siew C. Ng
    Global Prevalence of Helicobacter pylori Infection: Systematic Review and Meta-Analysis
    The epidemiology of Helicobacter pylori infection has changed with improvements in sanitation and methods of eradication. We performed a systematic review and meta-analysis to evaluate changes in the global prevalence of H pylori infection.


    Date de mise en ligne : Mercredi 26 avril 2017
    Stephen M. Laidlaw, Svetlana Marukian, Rachel H. Gilmore, SiobhĂĄn B. Cashman, Volodymyr Nechyporuk-Zloy, Charles M. Rice, Lynn B. Dustin
    Tumor Necrosis Factor Inhibits Spread of Hepatitis C Virus Among Liver Cells, Independent From Interferons
    Tumor necrosis factor (TNF) is an inflammatory cytokine expressed by human fetal liver cells (HFLCs) after infection with cell culture–derived hepatitis C virus (HCV). TNF has been reported to increase entry of HCV pseudoparticles into hepatoma cells and inhibit signaling by interferon alpha (IFNα), but have no effect on HCV-RNA replication. We investigated the effects of TNF on HCV infection of and spread among Huh-7 hepatoma cells and primary HFLCs.


    Date de mise en ligne : Vendredi 21 avril 2017
    Yujiro Hayashi, Yoshitaka Toyomasu, Siva Arumugam Saravanaperumal, Michael R. Bardsley, John A. Smestad, Andrea Lorincz, Seth T. Eisenman, Gianluca Cipriani, Molly H. Nelson Holte, Fatimah J. Al Khazal, Sabriya A. Syed, Gabriella B. Gajdos, Kyoung Moo Choi, Gary J. Stoltz, Katie E. Miller, Michael L. Kendrick, Brian P. Rubin, Simon J. Gibbons, Adil E. Bharucha, David R. Linden, Louis James Maher, Gianrico Farrugia, Tamas Ordog
    Hyperglycemia Increases Interstitial Cells of Cajal via MAPK1 and MAPK3 Signaling to ETV1 and KIT, Leading to Rapid Gastric Emptying
    Depletion of interstitial cells of Cajal (ICCs) is common in diabetic gastroparesis. However, in approximately 20% of patients with diabetes, gastric emptying (GE) is accelerated. GE also occurs faster in obese individuals, and is associated with increased blood levels of glucose in patients with type 2 diabetes. To understand the fate of ICCs in hyperinsulinemic, hyperglycemic states characterized by rapid GE, we studied mice with mutation of the leptin receptor (Leprdb/db), which in our colony had accelerated GE.


    Date de mise en ligne : Vendredi 21 avril 2017
    Lidiya G. Dimova, Jan Freark de Boer, Josee Plantinga, Torsten Plösch, Menno Hoekstra, Henkjan J. Verkade, Uwe J.F. Tietge
    Inhibiting Cholesterol Absorption During Lactation Programs Future Intestinal Absorption of Cholesterol in Adult Mice
    In nematodes, the intestine senses and integrates early life dietary cues that lead to lifelong epigenetic adaptations to a perceived nutritional environment—it is not clear whether this process occurs in mammals. We aimed to establish a mouse model of reduced dietary cholesterol availability from maternal milk and investigate the consequences of decreased milk cholesterol availability, early in life, on the metabolism of cholesterol in adult mice. We blocked intestinal absorption of cholesterol in milk fed to newborn mice by supplementing the food of dams (for 3 weeks between birth and weaning) with ezetimibe, which is secreted into milk.


    Date de mise en ligne : Jeudi 20 avril 2017
    Huihui Li, Matjaz Rokavec, Longchang Jiang, David Horst, Heiko Hermeking
    Antagonistic Effects of p53 and HIF1A on microRNA-34a Regulation of PPP1R11 and STAT3 and Hypoxia-induced Epithelial to Mesenchymal Transition in Colorectal Cancer Cells
    In colorectal tumors, hypoxia causes resistance to therapy and promotes metastasis. Loss of the tumor suppressor p53 (encoded by TP53) provides cancer cells with a selective advantage under conditions of hypoxia, but little is known about the mediators of this effect.


    Date de mise en ligne : Mardi 18 avril 2017
    MarĂ­a InĂ©s Pinto-SĂĄnchez, Natalia Causada-Calo, Premysl Bercik, Alexander C. Ford, Joseph A. Murray, David Armstrong, Carol Semrad, Sonia S. Kupfer, Armin Alaedini, Paul Moayyedi, Daniel A. Leffler, Elena F. VerdĂș, Peter Green
    Safety of Adding Oats to a Gluten-Free Diet for Patients With Celiac Disease: Systematic Review and Meta-analysis of Clinical and Observational Studies
    Patients with celiac disease should maintain a gluten-free diet (GFD), excluding wheat, rye, and barley. Oats might increase the nutritional value of a GFD, but their inclusion is controversial. We performed a systematic review and meta-analysis to evaluate the safety of oats as part of a GFD in patients with celiac disease.


    Date de mise en ligne : Lundi 17 avril 2017
    Jill Koshiol, Yu-Tang Gao, Michael Dean, Patricia Egner, Chirag Nepal, Kristine Jones, Bingsheng Wang, Asif Rashid, Wen Luo, Alison L. Van Dyke, Catterina Ferreccio, Michael Malasky, Ming-Chang Shen, Bin Zhu, Jesper B. Andersen, Allan Hildesheim, Ann W. Hsing, John Groopman
    Association of Aflatoxin and Gallbladder Cancer
    Aflatoxin, which causes hepatocellular carcinoma, may also cause gallbladder cancer. We investigated whether patients with gallbladder cancer have higher exposure to aflatoxin than patients with gallstones.


    Date de mise en ligne : Lundi 17 avril 2017
    Song-Yi Park, Carol J. Boushey, Lynne R. Wilkens, Christopher A. Haiman, LoĂŻc Le Marchand
    High-Quality Diets Associate With Reduced Risk of Colorectal Cancer: Analyses of Diet Quality Indexes in the Multiethnic Cohort
    Healthy eating patterns assessed by diet quality indexes (DQIs) have been related to lower risk of colorectal cancer—mostly among whites. We investigated the associations between 4 DQI scores (the Healthy Eating Index 2010 [HEI-2010], the Alternative Healthy Eating Index 2010 [AHEI-2010], the alternate Mediterranean diet score [aMED], and the Dietary Approaches to Stop Hypertension score) and colorectal cancer risk in the Multiethnic Cohort.


    Date de mise en ligne : Vendredi 24 février 2017
    Zhang-Hui Chen, Yan P. Yu, Junyan Tao, Silvia Liu, George Tseng, Michael Nalesnik, Ronald Hamilton, Rohit Bhargava, Joel B. Nelson, Arjun Pennathur, Satdarshan P. Monga, James D. Luketich, George K. Michalopoulos, Jian-Hua Luo
    MAN2A1–FER Fusion Gene Is Expressed by Human Liver and Other Tumor Types and Has Oncogenic Activity in Mice
    Human tumors and liver cancer cell lines express the product of a fusion between the first 13 exons in the mannosidase α class 2A member 1 gene (MAN2A1) and the last 6 exons in the FER tyrosine kinase gene (FER), called MAN2A1−FER. We investigated whether MAN2A1−FER is expressed by human liver tumors and its role in liver carcinogenesis.


    Date de mise en ligne : Mercredi 04 février 2015
    David T. Rubin
    The Rationale and Growth of Advanced Training in Inflammatory Bowel Disease


    Date de mise en ligne : Lundi 17 novembre 2014
    Steven F. Moss
    The Great Ulcer War: How It All Happened
    All gastroenterologists, most physicians, and many members of the general public are familiar with the discovery of gastric spiral bacteria in Western Australia in the early 1980s and the struggle to convince us that these bacteria, which we now call Helicobacter pylori, were a significant clinical issue. The eventual acceptance of Marshall and Warrren’s ideas resulted in their receiving the Nobel Prize for Medicine or Physiology in 2005. In contrast with the success story of triumph over adversity of these Antipodean pioneers that has been well-disseminated in the medical and lay media, little has been written about why the United States was particularly slow to accept the infectious theory of peptic ulcers.


    Date de mise en ligne : Lundi 19 novembre 2012
    Continuing Medical Education Answers: January 2013


    Date de mise en ligne : Lundi 15 octobre 2012
    Continuing Medical Education Answers: December 2012


    Date de mise en ligne : Mercredi 19 septembre 2012
    Ilaria Russo, Alessandro Luciani, Edoardo Troncone, Carolina Ciacci
    WITHDRAWN: The Endoplasmic Reticulum Stress Response Activates Tissue Transglutaminase and Intestinal Inflammation by Reducing Levels of IÎșBα
    This article has been withdrawn at the request of the authors. The Publisher apologizes for any inconvenience this may cause.The full Elsevier Policy on Article Withdrawal can be found at (http://www.elsevier.com/locate/withdrawalpolicy.


    Date de mise en ligne : Mercredi 22 août 2012
    Continuing Medical Education Answers: October 2012


    Date de mise en ligne : Jeudi 01 janvier 1970
    Information for Authors and Readers
    Gastroenterology is the premiere journal in the field of gastrointestinal disease and is led by an internationally renowned board of editors. As the official journal of the AGA Institute, Gastroenterology delivers up-to-date and authoritative coverage of both basic and clinical gastroenterology and hepatology. Regular features include research and perspectives by leading authorities, reports on the latest technologies for diagnosing and treating digestive diseases, images illustrating important clinical findings, reviews of scholarly media, medical news, meeting summaries, video abstracts, and monthly podcasts.


    Date de mise en ligne : Jeudi 01 janvier 1970
    Elsewhere in The AGA Journals


    Date de mise en ligne : Jeudi 01 janvier 1970
    Table of Contents


    Date de mise en ligne : Jeudi 01 janvier 1970
    Editorial Board


    Date de mise en ligne : Jeudi 01 janvier 1970
    Cover 1


    Date de mise en ligne : Jeudi 01 janvier 1970
    Erealda Prendaj, Daniel M. Fein, Nina Dadlez, John Thompson, Gitit Tomer
    Abstract 19 Timeliness to Antibiotics in Pediatric Short Bowel Syndrome Patients With Central Line and Fever in the Emergency Department
    Short bowel syndrome (SBS) patients have a higher rate of central line associated bloodstream infection (CLABSI) than patients without intestinal failure (7.8 vs 1.3 per 1000 catheter days). SBS patients have a high incidence of gram-negative bacteremia, which is known to carry a high rate of morbidity and mortality. Prompt administration of antibiotics is crucial for successful management of patients with central line and fever. Our aim was to decrease the time to antibiotics in SBS patients with central line and fever in the emergency department (ED) by 50% by December of 2016.


    Date de mise en ligne : Jeudi 01 janvier 1970
    Laurie B. Grossberg, Konstantinos Papamichail, Daniel A. Leffler, Mandeep S. Sawhney, Joseph D. Feuerstein
    Abstract 18 Increased Emergency Department Utilization Following Colonoscopy in the Elderly
    The United States Preventive Services Task Force (USPSTF) recommends screening for colorectal cancer in adults between 50 and 75 years of age. After age 75, the decision to pursue colonoscopy is patient-specific, and the age at which to stop screening or surveillance colonoscopy is not well established. Unplanned hospital visits within 7 days of colonoscopy is a new quality metric for colonoscopy. The incidence and etiology of unplanned hospital use after colonoscopy in the elderly is not well understood.


    Date de mise en ligne : Jeudi 01 janvier 1970
    Peter R. Caruana, Joel T. Bruggen
    Abstract 17 Improving Counseling and Interventions to Reduce HCV Transmission and Liver Disease Progression in Patients With Non-cirrhotic Chronic HCV Infection
    Current AASLD guidelines recommend measures directed at reducing HCV transmission and liver disease progression in patients with active HCV infection. These measures are routinely addressed in patients with cirrhosis; however, they can be overlooked in patients with non-cirrhotic chronic HCV infection. Our aim was to design an intervention to improve counseling and interventions in patients with non-cirrhotic chronic HCV infection.


    Date de mise en ligne : Jeudi 01 janvier 1970
    David I. Fudman, Lilach Roemi, Katharine A. Germansky, Robert Gianotti, Daniel Leffler, Joseph D. Feuerstein
    Abstract 16 Content of Consent for Colonoscopy: Comparison of Patient-Reported Preferences, Physician-Reported Practices, and Observed Practices (Poster Presentation)
    Little is known about physician and patient opinions and physician practices with regard to the content of consent for colonoscopy. We sought to measure these using 3 instruments: a survey of gastroenterologists (GIs), a survey of patients, and observations of actual consents.


    Date de mise en ligne : Jeudi 01 janvier 1970
    David I. Fudman, Konstantinos Papamichail, Lilach Roemi, Daniel Leffler, Joseph D. Feuerstein
    Abstract 15 Effect of Standardized Consent Versus Standardized Consent Plus Informational Booklet on Patient's Perceptions About Colonoscopy
    Data on the quality of consent for colonoscopy and its effect on patient views are scant. We performed a preliminary analysis that showed substantial variability in physician consent practices. Therefore, we first sought to standardize and improve the consent process through physician education, then to compare the impact of standardized consent vs standardized consent plus an informational booklet on patient perceptions regarding colonoscopy.


    Date de mise en ligne : Jeudi 01 janvier 1970
    Elizabeth Scoville, Quinn Wells, Shannon Peyton, Sara Horst, David Schwartz, Dawn W. Adams, Matthew S. Freiberg, Vanessa Gatskie, Stephen King, Hilary Tindle, Dawn Beaulieu
    Abstract 14 Creating a Personalized Smoking Cessation Pharmacotherapy Program in Smokers With Crohn’s Disease Utilizing Nicotine Metabolite Ratio (NMR)
    Smoking is a well-known risk factor for disease severity and complications in Crohn’s disease (CD). Despite being identified as a quality measure, little has been studied on promoting smoking cessation in CD. We recently showed that providing nicotine replacement (NRT) in the IBD clinic was effective but limited by low rates of participation. The nicotine metabolite ratio (NMR) is a biomarker of nicotine metabolism that predicts odds of cessation and response to varenicline. The aim of this study was to evaluate the feasibility of and engagement in a personalized smoking cessation program using NMR in an IBD clinic.


    Date de mise en ligne : Jeudi 01 janvier 1970
    Krista Edelman, Gabriel Mansouraty, Deborah Fisher, Ziad Gellad
    Abstract 13 Voice of the Veteran Analysis: Implementation of a Revised Pathology Letter After Colonoscopy
    The Veterans Health Administration (VHA) Gastroenterology Program aims to provide high-quality colonoscopies and timely communication of the procedure results. At our VA medical center, the previous colonoscopy pathology letters were brief and potentially unclear for patients unless significant information was manually added. Additionally, some veterans had voiced confusion regarding the implications and recommended follow-up outlined in the letters. The goals of this quality improvement (QI) project were to: (1) to measure baseline patient comprehension and satisfaction with the current colonoscopy pathology results letter, (2) to use Veteran and GI provider input to revise the letter, and (3) to measure patient comprehension and satisfaction with the revised letter.


    Date de mise en ligne : Jeudi 01 janvier 1970
    Zachary P. Fricker, Anna M. Leszczynski, Katherine T. Brunner, Reid Hopkins, Harini Naidu, Jason Reich, Akriti P. Saxena, Corbett Shelton, Ashish K. Tiwari, Sharmeel K. Wasan
    Abstract 12 Assessing the Quality of End-of-Life Care for Patients With End-Stage Liver Disease in a Safety-Net Hospital
    Patients with end-stage liver disease (ESLD) have delayed referral to palliative care or hospice despite prognostic indicators of their morbidity and mortality, such as elevated MELD scores and high rates of hospitalization. Their 1-month survival rate after hospice referral is half that of other patients with terminal diseases. They commonly undergo invasive procedures and suffer burdensome symptoms near the end of life. Costs to patients and the healthcare system often exceed the expected benefit.


    Date de mise en ligne : Jeudi 01 janvier 1970
    Shelini Sooklal, Neilanjan Nandi, Anand Kumar
    Abstract 11 Assessing the Success of a Multidisciplinary Quality Improvement Initiative to Improve Outpatient Screening Colonoscopy Bowel Preparation
    The quality of screening colonoscopy preparation is dependent upon pre-procedural bowel preparation. An abundance of poor and fair bowel preparations during screening colonoscopies at our tertiary care, a university ambulatory endoscopy center, prompted a quality improvement (QI) initiative to enhance screening colonoscopy quality and efficiency.


    Date de mise en ligne : Jeudi 01 janvier 1970
    Ricardo Badillo, Bader A. Alajlan, Chien-Huan Chen, Dayna S. Early
    Abstract 10 Implementation of a Standardized Sedation Classification System to Improve Endoscopy Unit Efficiency: A Quality Improvement Project
    As the patient population becomes more complex, our inpatient endoscopy unit (GIU) has increased its dependence on the anesthesia (ANES) department to assist with monitored anesthesia care (MAC) sedation. However, ANES staff availability is limited and can result in delays in procedure start times or cancellations of non-urgent cases at our busy academic center. Formerly, our sedation planning (FS) relied on attending preference and experience, and was affected by ANES availability. Therefore, we introduced a standardized sedation classification system (SS) to more adequately identify cases able to be performed with moderate sedation (MS) and decrease reliance on ANES support.


    Date de mise en ligne : Jeudi 01 janvier 1970
    Noemi Baffy, Diana Franco, Michael Crowell, Francisco Ramirez, Sarah Umar
    Abstract 9 A Good Bowel Prep, Can We as Physicians do Better?
    Colorectal cancer (CRC) is a leading cause of cancer death in the US and high-quality colonoscopy is key to efficient CRC screening and detection. Previous studies indicated that 18% to 31% of patients have inadequate bowel preparation. It has been reported that nearly 20% of patients with poor bowel preparation fail to follow instructions. We hypothesized that educating physicians who order colon purgatives with general tips on good quality bowel cleansing will improve the adequacy of preparation by helping to choose the most appropriate protocol tailored to each patients’ medical comorbidities.


    Date de mise en ligne : Jeudi 01 janvier 1970
    J.M. Tjaden, M.I. Beig, D.A. Labowitz, J.L. Goldstein
    Abstract 8 Celiac Disease Testing in Type I Diabetics: A Quality Assurance Project
    Celiac disease (CD) is more common in patients with Type I diabetes mellitus (DM) (3%—10%) than in the general population (∌1%). The American College of Gastroenterology recommends that patients with Type I DM should be tested for CD if there are any digestive symptoms, clinical signs of CD, or laboratory evidence suggestive of CD.1 The aim of this quality assurance project at North Shore University Health System (NSUHS) was to examine the rate of testing for CD in this at-risk population (compliance) and to evaluate individual physician adherence to this guideline.


    Date de mise en ligne : Jeudi 01 janvier 1970
    Ryan McConnell, Roshan Patel, Suzanne Sharpton, Fernando Velayos, Uma Mahadevan
    Abstract 7 Improving the Quality of Inpatient Ulcerative Colitis Management: Promoting Evidence-Based Practice and Reducing Care Variation
    Up to 25% of patients with ulcerative colitis (UC) will require hospitalization for severe disease, resulting in over 36,000 annual UC-related hospitalizations in the U.S. Hospitalization is a high-stakes, vulnerable event in a patient’s disease course. Disease severity of this magnitude increases the risk of colectomy and venous thromboembolism, and usually commits the patient to both a corticosteroid course and biologic therapy with the associated side effects and risks. Although inpatient quality measures and evidence-based management recommendations exist, there is variation in care delivery at our institution (Table 1).


    Date de mise en ligne : Jeudi 01 janvier 1970
    Scharles A. Konadu, Alyson A. McGhan, Jill Moore
    Abstract 6 The Boston Bowel Preparation Scale: Introduction of a Valid and Reliable Tool to the DVAMC Endoscopy Unit
    The US Multisociety Task Force on Colorectal Cancer screening requires appropriate reporting of the quality of the bowel preparation to appropriately recommend interval screening or surveillance. The Boston Bowel Preparation Scale (BBPS) is a validated, standardized scoring scale to assess bowel preparation. As part of a quality improvement initiative, we developed a method to transition the Durham VA Medical Center (DVAMC) endoscopy unit from our previously used subjective bowel preparation scoring system (excellent/good/fair/poor) to the objective Boston Bowel Preparation Scale.


    Date de mise en ligne : Jeudi 01 janvier 1970
    Anna Duloy, Jessica McClure, Claire Beveridge, Adam B. Gluskin, Robert Schenck, Mark Benson, Andrew J. Gawron, Charles Kahi, Tonya R. Kaltenbach, Rena H. Yadlapati, Rajesh N. Keswani
    Abstract 5 Colonoscopy-Naive Raters Can Accurately Assess Colonoscopy Inspection Quality
    A high-quality colonoscopy requires a thorough mucosal inspection to identify neoplastic polyps. Adenoma detection rate (ADR) and withdrawal time (WT) may be difficult to measure, are subject to ‘gaming,’ and do not provide actionable feedback for improvement. A standardized scale to assess colonoscopy inspection quality (CIQ) provides targeted feedback, but is time-consuming for raters. The aim of this study is to determine whether colonoscopy-naive (“novice”) rater assessments of CIQ correlate with expert rater assessments, and with standard metrics of colonoscopy quality.


    Date de mise en ligne : Jeudi 01 janvier 1970
    Sultan Mahmood, Karen Allen
    Abstract 4 Tube Feed App: A Novel Smart Phone Application for Enteral Nutrition
    Critical illness is characterized by a high catabolic state. American Society of Enteral and Parenteral Nutrition (ASPEN) and European Society of Enteral and Parenteral Nutrition (ESPEN) recommend early nutritional support, regardless of the previous nutritional status. However, in most cases enteral nutrition is delayed because of lack of knowledge and training of treating physicians. Our study’s aim was to assess improvement in enteral nutrition practices and patient outcomes after introduction of a smart phone application for tube feeding.


    Date de mise en ligne : Jeudi 01 janvier 1970
    Srihari Mahadev, Daniel Freedberg
    Abstract 3 Impact of Trainee Experience on the Decision to Perform Endoscopy on Weekends
    Guidelines recommend endoscopy with 24 hours of admission for patients who present with suspected upper gastrointestinal bleeding (GIB). Endoscopy units often operate only during weekdays, however, resulting in logistical barriers to performing endoscopy on weekends. Weekend endoscopy is therefore typically reserved for a subset of higher acuity patients. We sought to determine if trainee experience influences the decision to proceed with upper endoscopy on weekends.


    Date de mise en ligne : Jeudi 01 janvier 1970
    Srihari Mahadev, Benjamin Lebwohl, Daniel Freedberg
    Abstract 2 Trainee Colonoscopy Withdrawal Time Is Influenced by the Independent Performance Characteristics of Supervising Physicians
    Adenoma detection rate (ADR) and withdrawal time (WT) are important measures used to evaluate the quality of screening colonoscopy. Trainee quality measures have been shown to correlate with performance in independent practice, but the factors that determine quality during fellowship are poorly understood. We sought to determine if the performance characteristics of supervising physicians can influence the quality of the screening colonoscopies performed by trainees under their supervision.


    Date de mise en ligne : Jeudi 01 janvier 1970
    Shirley Cohen-Mekelburg, Stephanie Gold, Yecheskel Schneider, Madison Dennis, Clara Oromendia, Fabrizio Michelassi, Ellen Scherl, Adam Steinlauf
    Abstract 1 Barriers to Post-Surgical Biologic Therapy in Crohn’s Disease
    A significant proportion of patients with Crohn's disease (CD) will develop complications requiring surgery. However, surgery is not a cure for CD, and a majority will develop disease recurrence. Multiple studies have shown that infliximab and adalimumab can reduce rates of post-surgical recurrence, particularly with a preventative approach. Anecdotally, we see many CD patients returning to care after a surgical resection with recurrent symptoms that could have potentially been prevented with post-operative biologic therapy.