Vous êtes ici : Accueil > Espace Médecin > La revue de Presse > Gastroenterology

Mise à jour le : 30-03-2017

| | |




Les derniers abstracts de la revue Gastroenterology :


    Date de mise en ligne : Mercredi 29 mars 2017
    Antonio Carroccio, Alberto D’Alcamo, Giuseppe Iacono, Maurizio Soresi, Rosario Iacobucci, Andrea Arini, Girolamo Geraci, Francesca Fayer, Francesca Cavataio, Francesco La Blasca, Ada M. Florena, Pasquale Mansueto
    Persistence of Non-Celiac Wheat Sensitivity, Based on Long-term Follow Up
    We investigated how many patients with a diagnosis of non-celiac wheat sensitivity (NCWS) still experienced wheat sensitivity after a median follow-up time of 99 months. We collected data from 200 participants from a previous study of NCWS, performed between July and December 2016 in Italy;148 of these individuals were still on a strict wheat-free diet. In total, 175 patients (88%) improved (had fewer symptoms) after a diagnosis of NCWS; 145 of 148 patients who adhered strictly to a gluten-free diet (98%) had reduced symptoms, compared to 30 of 52 patients who did not adhere to a gluten-free diet (58%) (P<.0001).


    Date de mise en ligne : Mercredi 29 mars 2017
    Xi Liu, Min Zhang, Songmin Ying, Chong Zhang, Runhua Lin, Jiaxuan Zheng, Guohong Zhang, Dongping Tian, Yi Guo, Caiwen Du, Yuping Chen, Shaobin Chen, Xue Su, Juan Ji, Wanting Deng, Xiang Li, Shiyue Qiu, Ruijing Yan, Zexin Xu, Yuan Wang, Yuanning Guo, Jiancheng Cui, Shanshan Zhuang, Huan Yu, Qi Zheng, Moshe Marom, Sitong Sheng, Guoqiang Zhang, Songnian Hu, Ruiqiang Li, Min Su
    Genetic Alterations as Esophageal Tissues From Squamous Dysplasia to Carcinoma
    Esophageal squamous cell carcinoma (ESCC) is most common subtype of esophageal cancer. Little is known about the genetic changes that occur in esophageal cells during development of ESCC. We performed next-generation sequence analyses of esophageal non-tumor, intraepithelial neoplasia (IEN), and ESCC tissues from the same patients to track genetic changes during tumor development.


    Date de mise en ligne : Mardi 28 mars 2017
    Peter B. Ernst
    Our new president – Sheila E. Crowe MD


    Date de mise en ligne : Mardi 28 mars 2017
    Pere Ginès
    Juan Rodés, in Memoriam


    Date de mise en ligne : Mardi 28 mars 2017
    J. Howell, A.J. Thompson
    Hepatocellular carcinoma post-SVR – leave no-one behind


    Date de mise en ligne : Mardi 28 mars 2017
    Weilong Zhang, Huan He, Mengya Zang, Qifeng Wu, Hong Zhao, Ling-ling Lu, Peiqing Ma, Hongwei Zheng, Nengjin Wang, Ying Zhang, Siyuan He, Xiaoyan Chen, Zhiyuan Wu, Xiaoyue Wang, Jianqiang Cai, Zhihua Liu, Zongtang Sun, Yi-xin Zeng, Chunfeng Qu, Yuchen Jiao
    Genetic Features of Aflatoxin-associated Hepatocellular Carcinomas
    Dietary exposure to aflatoxin is an important risk factor for hepatocellular carcinoma (HCC). However, little is known about the genomic features and mutations of aflatoxin-associated HCCs compared with HCCs not associated with aflatoxin exposure. We investigated the genetic features of aflatoxin-associated HCC that can be used to differentiate them from HCCs not associated with this carcinogen.


    Date de mise en ligne : Mardi 28 mars 2017
    Wafa Khamri, Robin D. Abeles, Tie Zheng Hou, Amy E. Anderson, Ahmed El-Masry, Evangelos Triantafyllou, Christine Bernsmeier, Fin S. Larsen, Arjuna Singanayagam, Nobuaki Kudo, Lucia A. Possamai, Fanny Lebosse, Georg Auzinger, William Bernal, Christopher Willars, Christopher J. Weston, Giovanna Lombardi, Julia Wendon, Mark Thursz, Charalambos G. Antoniades
    Increased Expression of CTLA4 by T Cells, Induced by B7 in Sera, Reduces Adaptive Immunity in Patients With Acute Liver Failure
    Patients with acute liver failure (ALF) have defects in innate immune responses to microbes (immuneparesis) and are susceptible to sepsis. Cytotoxic T-lymphocyte associated protein 4 (CTLA4), which interacts with the membrane receptor B7 (also called CD80 and CD86), is a negative regulator of T-cell activation. We collected T cells from patients with ALF and investigated whether inhibitory signals downregulate adaptive immune responses in patients with ALF.


    Date de mise en ligne : Mardi 28 mars 2017
    Andrew King, Diarmaid D. Houlihan, Dean Kavanagh, Debashis Haldar, Nguyet Luu, Andrew Owen, Shankar Suresh, Nwe Ni Than, Gary Reynolds, Jasmine Penny, Henry Sumption, Prakash Ramachandran, Neil C. Henderson, Neena Kalia, Jon Frampton, David H. Adams, Philip N. Newsome
    Sphingosine-1-phosphate Prevents Egress of Hematopoietic Stem Cells From Liver to Reduce Fibrosis
    There is growing interest in the use of bone marrow cells to treat liver fibrosis, however little is known about their anti-fibrotic efficacy or the identity of their effector cell(s). Sphingosine-1-phosphate (S1P) mediates egress of immune cells from the lymphoid organs into the lymphatic vessels; we investigated its role in the response of hematopoietic stem cells (HSC) to liver fibrosis in mice.


    Date de mise en ligne : Mardi 28 mars 2017
    Carol Durno, C. Richard Boland, Shlomi Cohen, Jason A. Dominitz, Frank M. Giardiello, David A. Johnson, Tonya Kaltenbach, T.R. Levin, David Lieberman, Douglas J. Robertson, Douglas K. Rex
    Recommendations on Surveillance and Management of Biallelic Mismatch Repair Deficiency (BMMRD) Syndrome: A Consensus Statement by the US Multi-Society Task Force on Colorectal Cancer
    The US Multi-Society Task Force on Colorectal Cancer, with invited experts, developed a consensus statement and recommendations to assist health care providers with appropriate management of patients with biallelic mismatch repair deficiency (BMMRD) syndrome, also called constitutional mismatch repair deficiency syndrome. This position paper outlines what is known about BMMRD, the unique genetic and clinical aspects of the disease, and reviews the current management approaches to this disorder. This article represents a starting point from which diagnostic and management decisions can undergo rigorous testing for efficacy.


    Date de mise en ligne : Lundi 27 mars 2017
    Ying Zhang, Karin Seid, Florian Obermayr, Lothar Just, Peter H. Neckel
    Activation of Wnt Signaling Increases Numbers of Enteric Neurons Derived From Neonatal Mouse and Human Progenitors Cells
    Neural stem and progenitor cells from the enteric nervous system (ENS) might serve as a source of cells for treatment of neurogastrointestinal disorders. Before we can use these cells, we must increase our understanding of the signaling mechanisms that regulate proliferation and differentiation. We systematically evaluated the effects of canonical Wnt signaling on proliferation and differentiation of cultured ENS progenitor cells from neonatal mice and humans.


    Date de mise en ligne : Samedi 25 mars 2017
    Jennifer Nayor, John R. Saltzman
    Should we all be using the Doppler endoscopic probe in non-variceal upper gastrointestinal bleeding?


    Date de mise en ligne : Samedi 25 mars 2017
    Domenico Alvaro
    Gallstones: bad company for the steatotic liver


    Date de mise en ligne : Jeudi 23 mars 2017
    Ira M. Jacobson, Joseph K. Lim, Michael W. Fried
    AGA Institute Clinical Practice Update: Care of Patients Who Have Achieved a Sustained Virologic Response (SVR) Following Antiviral Therapy for Chronic Hepatitis C Infection
    Chronic hepatitis C virus (HCV) infection is well-recognized as a common blood borne infection with global public health impact, affecting 3 to 5 million persons in the U.S. and over 170 million persons worldwide. Chronic HCV infection is associated with significant morbidity and mortality due to complications of liver cirrhosis and hepatocellular carcinoma (HCC). Current therapies with all-oral directly acting antiviral agents (DAAs) are associated with high rates of sustained virologic response (SVR), generally exceeding 90%.


    Date de mise en ligne : Mercredi 22 mars 2017
    Mircea T. Chiriac, Barbara Buchen, Alexandra Wandersee, Gheorghe Hundorfean, Claudia Günther, Yvonne Bourjau, Sean E. Doyle, Benjamin Frey, Arif B. Ekici, Christian Büttner, Benno Weigmann, Raja Atreya, Stefan Wirtz, Christoph Becker, Jürgen Siebler, Markus F. Neurath
    Activation of Epithelial STAT1 by Interleukin 28 Controls Mucosal Healing in Mice with Colitis and is Increased in Mucosa of Patients With Inflammatory Bowel Disease
    We investigated the roles of interleukin 28A (also called IL28A or interferon lambda 2) in intestinal epithelial cell (IEC) activation, studying its effects in mouse models of inflammatory bowel diseases (IBD) and intestinal mucosal healing.


    Date de mise en ligne : Mercredi 22 mars 2017
    Frank Pui-Ling Lai, Sin-Ting Lau, John Kwong-Leong Wong, Hongsheng Gui, Reeson Xu Wang, Tingwen Zhou, Wing Hon Lai, Hung-Fat Tse, Paul Kwong-Hang Tam, Maria-Mercedes Garcia-Barcelo, Elly Sau-Wai Ngan
    Correction of Hirschsprung-associated Mutations in Human Induced Pluripotent Stem Cells, via CRISPR/Cas9, Restores Neural Crest Cell Function
    Hirschsprung disease is caused by failure of enteric neural crest cells (ENCCs) to fully colonize the bowel, leading to bowel obstruction and megacolon. Heterozygous mutations in the coding region of the RET gene cause a severe form of Hirschsprung disease (total colonic aganglionosis). However, 80% of HSCR patients have short-segment Hirschsprung disease (S-HSCR), which has not been associated with genetic factors. We sought to identify mutations associated S-HSCR, and used the CRISPR/Cas9 gene editing system to determine how mutations affect ENCC function.


    Date de mise en ligne : Dimanche 19 mars 2017
    Huma Q. Rana, Sapna Syngal
    Biallelic Mismatch Repair Deficiency Syndrome– Management and Prevention of a Devastating Manifestation of Lynch syndrome


    Date de mise en ligne : Dimanche 19 mars 2017
    Poonam Mishra, Minjun Chen
    Direct-Acting Antivirals for Chronic Hepatitis C: Can Drug Properties Signal Potential for Liver Injury?


    Date de mise en ligne : Dimanche 19 mars 2017
    Maria T. Abreu, Oriana M. Damas, Felipe Neri Piñol Jiménez, Roberto Cañete
    US-Cuba research collaborations: opening bridges for gastroenterology


    Date de mise en ligne : Dimanche 19 mars 2017
    James R. Goldenring
    The AGA/Funderburg Award in Gastric Cancer: Twenty-five years of advances in gastric cancer research


    Date de mise en ligne : Samedi 18 mars 2017
    Spencer D. Dorn
    Academic Gastroenterology Practice in a Value-Based World: One Size No Longer Fits All


    Date de mise en ligne : Jeudi 16 mars 2017
    Shu-Heng Jiang, Jun Li, Fang-Yuan Dong, Jian-Yu Yang, De-Jun Liu, Xiao-Mei Yang, Ya-Hui Wang, Min-Wei Yang, Xue-Liang Fu, Xiao-Xin Zhang, Qing Li, Xiu-Feng Pang, Yan-Miao Huo, Jiao Li, Jun-Feng Zhang, Ho-Young Lee, Su-Jae Lee, Wen-Xin Qin, Jian-Ren Gu, Yong-Wei Sun, Zhi-Gang Zhang
    Increased Serotonin Signaling Contributes to the Warburg Effect in Pancreatic Tumor Cells under Metabolic Stress and Promotes Growth of Pancreatic Tumors in Mice
    The desmoplasia and poor vascularity cause severe metabolic stress in pancreatic ductal adenocarcinomas (PDACs). Serotonin (5-HT) is a neuromodulator with neurotransmitter and neuroendocrine functions that contributes to tumorigenesis. We investigated the role of 5-HT signaling in the growth of pancreatic tumors.


    Date de mise en ligne : Vendredi 10 mars 2017
    David Saadoun, Stanislas Pol, Yasmina Ferfar, Laurent Alric, Christophe Hezode, Si Nafa Si Ahmed, Luc de Saint Martin, Cloé Comarmond, Anne Sophie Bouyer, Lucile Musset, Thierry Poynard, Matthieu Resche Rigon, Patrice Cacoub
    Efficacy and Safety of Sofosbuvir plus Daclatasvir for Treatment of HCV-associated Cryoglobulinemia Vasculitis
    Circulating mixed cryoglobulins are detected in 40%–60% of patients with hepatitis C virus (HCV) infection, and overt cryoglobulinemia vasculitis (CryoVas) develops in about 15% of patients. Remission of vasculitis has been associated with viral clearance, but few studies have reported the effectiveness of direct acting antiviral drugs in these patients. We performed open-label, prospective, multi-center study of the effectiveness and tolerance of an all-oral, interferon- and ribavirin-free regimen of sofosbuvir plus daclatasvir in patients with HCV-associated CryoVas.


    Date de mise en ligne : Jeudi 09 mars 2017
    Patrik Nasr, Mikael F. Forsgren, Simone Ignatova, Nils Dahlström, Gunnar Cedersund, Olof Dahlqvist Leinhard, Bengt Norén, Mattias Ekstedt, Peter Lundberg, Stergios Kechagias
    Using a 3% Proton Density Fat Fraction as a Cut-off Value Increases Sensitivity of Detection of Hepatic Steatosis, Based on Results from Histopathology Analysis
    It is possible to estimate hepatic triglyceride content by calculating the proton density fat fraction (PDFF), using proton magnetic resonance spectroscopy (1H-MRS), instead of collecting and analyzing liver biopsies to detect steatosis. However, the current PDFF cut-off value (5%) used to define steatosis by magnetic resonance was derived from studies that did not use histopathology as the reference standard. We performed a prospective study to determine the accuracy of 1H-MRS PDFF in measurement of steatosis using histopathology analysis as the standard.


    Date de mise en ligne : Jeudi 09 mars 2017
    Eva A. Ebbing, Anne Steins, Evelyn Fessler, Phylicia Stathi, Willem Joost Lesterhuis, Kausilia K. Krishnadath, Louis Vermeulen, Jan Paul Medema, Maarten F. Bijlsma, Hanneke W.M. van Laarhoven
    Esophageal Adenocarcinoma Cells and Xenograft Tumors Exposed to Erb-b2 Receptor Tyrosine Kinase 2 and 3 Inhibitors Activate Transforming Growth Factor Beta Signaling, Which Induces Epithelial to Mesenchymal Transition
    Drugs that inhibit the erb-b2 receptor tyrosine kinase 2 (ERBB2 or HER2) are the standard treatment of patients with different types of cancer, including HER2-overexpressing gastroesophageal tumors. Unfortunately, cancer cells become resistant to these drugs, so overall these drugs provide little benefit to patients with these tumors. We investigated mechanisms that mediate resistance of esophageal adenocarcinoma (EAC) cells and patient-derived xenograft (PDX) tumors to ERBB inhibitors.


    Date de mise en ligne : Mercredi 08 mars 2017
    Bin Chen, Wei Wei, Li Ma, Bin Yang, Ryan M. Gill, Mei-Sze Chua, Atul J. Butte, Samuel So
    Computational Discovery of Niclosamide Ethanolamine, A Repurposed Drug Candidate That Reduces Growth of Hepatocellular Carcinoma Cells in Vitro and in Mice by Inhibiting CDC37 Signaling
    Drug repositioning offers a shorter approval process than new drug development. We therefore searched large public datasets of drug-induced gene expression signatures to identify agents that might be effective against hepatocellular carcinoma (HCC).


    Date de mise en ligne : Mardi 07 mars 2017
    Marina Serper, Tamar H. Taddei, Rajni Mehta, Kathryn D’Addeo, Feng Dai, Ayse Aytaman, Michelle Baytarian, Rena Fox, Kristel Hunt, David S. Goldberg, Adriana Valderrama, David E. Kaplan, VOCAL Study Group
    Association of Provider Specialty and Multi-disciplinary Care with Hepatocellular Carcinoma Treatment and Mortality
    Little is known about provider and health system factors that affect receipt of active therapy and outcomes of patients with hepatocellular carcinoma (HCC). We investigated patient, provider, and health system factors associated with receipt of active HCC therapy and overall survival.


    Date de mise en ligne : Mardi 07 mars 2017
    Andrew T. Chan, Christopher S. Williams
    Covering the Cover
    A novel, fluorescently labeled peptide topically administered to the proximal colon distinguished sessile serrated adenomas from normal colonic mucosa with 89% sensitivity and 92% specificity in a small trial.


    Date de mise en ligne : Dimanche 05 mars 2017
    Tobias J. Weismüller, Palak J. Trivedi, Annika Bergquist, Mohamad Imam, Henrike Lenzen, Cyriel Y. Ponsioen, Kristian Holm, Daniel Gotthardt, Martti A. Färkkilä, Hanns- Ulrich Marschall, Douglas Thorburn, Rinse K. Weersma, Johan Fevery, Tobias Mueller, Olivier Chaouillères, Kornelius Schulze, Konstantinos N. Lazaridis, Sven Almer, Stephen P. Pereira, Cynthia Levy, Andrew Mason, Sigrid Naess, Christopher L. Bowlus, Annarosa Floreani, Emina Halilbasic, Kidist K. Yimam, Piotr Milkiewicz, Ulrich Beuers, Dep K. Huynh, Albert Pares, Christine N. Manser, George N. Dalekos, Bertus Eksteen, Pietro Invernizzi, Christoph P. Berg, Gabi I. Kirchner, Christoph Sarrazin, Vincent Zimmer, Luca Fabris, Felix Braun, Marco Marzioni, Brian D. Juran, Karouk Said, Christian Rupp, Kalle Jokelainen, Maria Benito de Valle, Francesca Saffioti, Angela Cheung, Michael Trauner, Christoph Schramm, Roger W. Chapman, Tom H. Karlsen, Erik Schrumpf, Christian P. Strassburg, Michael P. Manns, Keith D. Lindor, Gideon M. Hirschfield, Bettina E. Hansen, Kirsten M. Boberg., International PSC Study Group
    Patient Age, Sex, and Inflammatory Bowel Disease Phenotype Associate With Course of Primary Sclerosing Cholangitis
    Primary sclerosing cholangitis (PSC) is an orphan hepatobiliary disorder associated with inflammatory bowel disease (IBD). We aimed to estimate the risk of disease progression based on distinct clinical phenotypes in a large, international cohort of patients with PSC.


    Date de mise en ligne : Dimanche 05 mars 2017
    Cloé Comarmond, Marlène Garrido, Stanislas Pol, Anne-Claire Desbois, Myrto Costopoulos, Magali Le Garff-Tavernier, Si Nafa Si Ahmed, Laurent Alric, Hélène Fontaine, Bertrand Bellier, Anna Maciejewski, Michelle Rosenzwajg, David Klatzmann, Lucile Musset, Thierry Poynard, Patrice Cacoub, David Saadoun
    Direct-acting Antiviral Therapy Restores Immune Tolerance to Patients With Hepatitis C Virus-induced Cryoglobulinemia Vasculitis
    Interferon-free direct-acting antiviral (DAA) therapies are effective in patients with hepatitis C virus-induced cryoglobulinemia vasculitis (HCV-CV). We analyzed blood samples from patients with HCV-CV before and after DAA therapy to determine mechanisms of these drugs and their effects on cellular immunity.


    Date de mise en ligne : Dimanche 05 mars 2017
    Patrick T.F. Kennedy, Antonio Bertoletti, William S. Mason
    Reply
    In 1985, Drs Chu, Liaw, and colleagues described the first phase of chronic hepatitis, referred to as immune tolerant (IT), as “The high replicative phase, characterized by HBeAg reactivity in serum and only minor histologic activity,” including nonspecific reactive hepatitis and chronic persistent hepatitis.1 The high virus titers in IT patients (≥109/mL) and minimal liver damage were taken as evidence that there was no immune activity against infected hepatocytes. The IT designation was reasonable, considering evidence then available.


    Date de mise en ligne : Dimanche 05 mars 2017
    Rinaldo Pellicano
    A Question on Liver Function Tests in Patients With Celiac Disease
    I read with great interest the study by Choung et al1 conducted on a population living in Olmsted County, Minnesota. In this community, the prevalence of undiagnosed celiac disease was 1%. Furthermore, to compare the proportion of comorbidities between undiagnosed cases of celiac disease and age- and sex-matched seronegative subjects, a nested case control study was performed. Analyzing the difference of laboratory parameters the authors found lower ferritin levels (P = .01) and cholesterol levels (P = .03) in cases of undiagnosed celiac disease than in controls.


    Date de mise en ligne : Dimanche 05 mars 2017
    Yun-Fan Liaw, Chia-Ming Chu
    Immune Tolerance Phase of Chronic Hepatitis B
    We read with great interest the article of Mason et al1 and 2 related editorials2,3 debating the suitability of the time-honored term immune tolerance phase. Their debate was based on current molecular and immunologic findings, and did not reach a consensus. From clinical point of view, we concur with Dr Milich that the term/concept of immune tolerance is still valid.


    Date de mise en ligne : Dimanche 05 mars 2017
    Shaun Q.W. Lee, Rafay Azhar, Brian K.P. Goh
    An Unusual Cause of an Arterial Enhancing Liver Mass
    Question: A 47-year-old woman was referred to our department for a liver mass. She had a significant past history of being a hepatitis B carrier on yearly abdominal ultrasound imaging in an outpatient setting. Her last abdominal ultrasound was performed on May 2014, and was reported as being normal. She was asymptomatic. Physical examination was unremarkable. She underwent an abdominal ultrasound on August 2015, which showed a 3.8-cm hypoechoic lesion in the lateral segment of the liver. Her alpha-fetoprotein and liver function tests were normal.


    Date de mise en ligne : Dimanche 05 mars 2017
    Justin Brandler, Tsung-Teh Wu, Seth Sweetser
    Young Onset Breast and Colon Cancer
    Question: A 37-year-old G2P1 woman was diagnosed with ER+, PR+, Her-2 negative invasive ductal carcinoma without metastasis at 35 weeks’ gestation and after labor induction underwent neoadjuvant chemotherapy with bilateral mastectomy. BRCA1/2 testing was negative.


    Date de mise en ligne : Dimanche 05 mars 2017
    Ali Raza, Ayah Oglat, Kumar Krishnan
    Uncommon Cause of Dysphagia in a Liver Transplant Recipient
    Question: A 71-year-old woman with a past medical history of living unrelated donor transplant done 15 years ago for primary biliary cirrhosis was referred for evaluation of dysphagia. Dysphagia was primarily to solid foods and later progressed to thick liquids. Symptoms started 1 year ago, and were associated with 100-pound weight-loss. There was no associated odynophagia, cough during swallowing, nasal regurgitation, food impaction, or gastrointestinal bleeding. She had mild gastroesophageal reflux symptoms.


    Date de mise en ligne : Dimanche 05 mars 2017
    Werner Keenswijk, Dirk Van de Putte
    An Adolescent With Severe Abdominal Pain, An Unexpected Outcome
    Question: A 14-year-old girl of African descent, presented with severe abdominal pain at the pediatric department. The pain had started 3 days earlier and initially was intermittent, diffuse, and cramping. At presentation it had become continuous, progressively increasing in intensity, and accompanied by vomiting up to 3 times a day. She reported the tendency to move around constantly in search of a comfortable position. There was no fever, diarrhea, or dysuria and she regularly passed stool. Her medical history was unremarkable and she claimed not to be sexually active.


    Date de mise en ligne : Samedi 04 mars 2017
    Shiv K. Sarin, Ashok Choudhury, Cyriac A. Philips, Patrick Kamath, Hitoshi Maruyama, Dominique Valla
    Reply
    We are thankful to Dr Mancuso for showing interest in our recently published commentary entitled “Toward a Comprehensive New Classification of Portal Vein Thrombosis in Patients With Cirrhosis.”1


    Date de mise en ligne : Samedi 04 mars 2017
    Rok Seon Choung, Joseph A. Murray
    Reply
    We thank Dr Pellicano for his interest in our study.1 Although the prevalence of clinically significant liver disease in patients with celiac disease is quite low,2 we agree that as many as 40% of patients with celiac disease may have elevated liver enzymes at the time of diagnosis. 3 Furthermore, some studies4,5 showed that celiac disease is responsible for abnormal liver tests among ≤10% of patients with cryptogenic hepatitis. However, most studies on abnormal liver function tests in celiac disease have studied patients who were already diagnosed with celiac disease, not those with undiagnosed celiac disease.


    Date de mise en ligne : Samedi 04 mars 2017
    David R. Mitchell, Mohammad H. Derakhshan, Angela A. Wirz, Stuart A. Ballantyne, Kenneth E.L. McColl
    Abdominal Compression by Waist Belt Aggravates Gastroesophageal Reflux, primarily by Impairing Esophageal Clearance
    Central obesity promotes gastroesophageal reflux and this may be related to increased intra-abdominal pressure. We investigated the effect of increasing abdominal pressure by waist belt on reflux in patients with reflux disease.


    Date de mise en ligne : Vendredi 03 mars 2017
    Andrew J. Read, Michelle M. Muza-Moons
    Patient-focused IBD Applications Review
    The rise of smartphones and tablets has fundamentally transformed the way we interact. Mobile applications, or “apps,” created for smartphones and tablets and distributed via the Apple store (for Apple iOS devices) and the Google Play store (for Android devices), have created innumerable uses for devices once limited to telephone calls.


    Date de mise en ligne : Vendredi 03 mars 2017
    Andrea Mancuso
    Classification of Portal Vein Thrombosis in Cirrhosis
    I believe that further comments are appropriate about the need of a new classification of portal vein thrombosis (PVT) in patients with cirrhosis, as discussed in the interesting paper recently published in Gastroenterology.1


    Date de mise en ligne : Vendredi 03 mars 2017
    Yoichi Nakayama, Akihisa Fukuda, Yuzo Kodama
    A Tumor Localized in the Portal Vein
    Question: A 56-year-old man underwent annual abdominal ultrasonography (US) as a medical checkup and a mass was found in his portal vein. Further examination was required and he was admitted to our hospital. He had no significant chief complaints, family history, or past medical history. On physical examination, no significant findings were revealed. Laboratory data were as follows: aspartate aminotransferase of 57 IU/L, alanine aminotransferase of 42 IU/L, lactate dehydrogenase of 302 IU/L, and γ-glutamyltransferase of 248 IU/L.


    Date de mise en ligne : Vendredi 03 mars 2017
    Ahmed Akhter, Erin Brooks, Patrick Pfau
    An Unusual Case of Polymicrobial Bacteremia
    Question: A 75-year-old woman with a history of chronic obstructive lung disease, alcoholic cirrhosis, and a recent episode of polymicrobial bacteremia (Enterococcus avium and Bacteroides) at an outside hospital 2 months before presentation was admitted with shortness of breath and abdominal pain. Blood cultures on hospital day 1 demonstrated vancomycin-resistant enterococcus bacteremia. She was placed on daptomycin but developed hypotension, oliguria, and altered mental status. She was diagnosed with septic shock.


    Date de mise en ligne : Mercredi 01 mars 2017
    Andrew E. Hendifar, Lynne Davies, Richard Tuli
    Private Funding for Pancreatic Cancer Research: More Than a Chip Shot
    Cancer is the second leading cause of death in the United States and is projected to soon overcome heart disease as the world’s largest health problem.1 In contrast with improving outcomes for most common malignancies, mortality rates of pancreatic cancer and liver cancer are worsening for both men and women2,3; they are projected to be the second and third most common cause of cancer-related deaths before 2030, respectively (Figure 1). The 5-year survival is only 8% for pancreatic cancer and 17.5% for liver cancer.


    Date de mise en ligne : Mercredi 01 mars 2017
    Elliot B. Tapper, Neil Sengupta
    How to Succeed in Research During Fellowship: What the Trainee Needs To Do (and Needs From the Program)
    Research during training complements learning, helping to develop and reinforce core competencies. Research is also associated with enhanced career satisfaction and superior clinical performance.1,2 Although scholarly activity is a required component of postgraduate medical education, enthusiasm for and participation in research by trainees is suboptimal.2–5 At least 2 gastroenterology fellowship programs have described curricular innovations to enhance research training resulting in measurably increased scholarly output.


    Date de mise en ligne : Mercredi 01 mars 2017
    Stuart J. Forbes
    Milk Fat Globule-EGF Factor 8 for Liver Fibrosis Therapy: Creaming Off the Beneficial Effects of Mesenchymal Stromal Cells
    There is a global increase in the incidence of liver cirrhosis, and although specific disease therapies are available, there is a large population of patients with advanced cirrhosis who are prone to regular decompensation and an increased risk of liver-related death. Although end-stage liver cirrhosis can be treated by liver transplantation, this option is limited owing to a global shortage of suitable organs. Even if liver transplantation is possible, it necessitates lifelong immunosuppression, which carries increased risk of associated morbidities.


    Date de mise en ligne : Mercredi 01 mars 2017
    Jean-Charles Nault
    Cancer Gene Discovery in Hepatocellular Carcinoma: The CRISPR/CAS9 Accelerator
    Recent advances in gene editing have enabled us to easily manipulate DNA using CRISPR (clustered regularly interspaced short palindromic repeats)/CAS9 (CRISPR-associated protein 9) technology.1 CRISPR/CAS9 is an endonuclease that exploits the DNA double-strand break repair pathway to cleave DNA at specific DNA target sites.1 These properties have been translated into the ability to rapidly and precisely modify DNA in cells, a technological revolution that is accelerating biological research.2 In vivo RNA interference screening has been used previously in mouse models to identify the genes involved in liver tumorogenesis or in resistance to biotherapy.


    Date de mise en ligne : Mercredi 01 mars 2017
    Ashwani K. Singal, Vijay H. Shah, Patrick S. Kamath
    Infection in Severe Alcoholic Hepatitis: Yet Another Piece in the Puzzle
    Patients with cirrhosis are at risk for infections, with infection risk likely being more common in patients with alcoholic than nonalcoholic cirrhosis.1 In a study using the National Inpatient Database Sample, 25% of patients with cirrhosis (about 50% alcohol related) carried a discharge diagnosis of infection.2 In prospective studies, infections at admission occur in 12% to 26% of patients with severe alcoholic hepatitis (AH).3–5 Data on the frequency of infection during hospitalization are inconsistent, because the suspicion for infection varies depending on the treating clinician.


    Date de mise en ligne : Mercredi 01 mars 2017
    David A. Katzka, Gary W. Falk
    Management of Low-Grade Dysplasia in Barrett’s Esophagus: Incremental Progress Continues
    In this issue of Gastroenterology, Duits et al1 from the Netherlands have expanded on their prior contributions to the low-grade dysplasia (LGD) literature in a study that examined outcomes of patients screened but not eligible for the SURF (Surveillance vs Radiofrequency Ablation) randomized clinical trial of radiofrequency ablation versus surveillance for LGD as well as those in the observation only group of that study.1 They found that 45 of the 255 patients (18%) with baseline LGD developed high-grade dysplasia (HGD)/esophageal adenocarcinoma (EAC) during a median of 42 months of follow-up if 3 expert pathologists agreed on the presence of LGD.


    Date de mise en ligne : Mercredi 01 mars 2017
    Eamonn M.M. Quigley, Anthony J. Lembo
    Irritable Bowel Syndrome: An Infectious Disease?
    Although the current literature would suggest that postinfectious irritable bowel syndrome (PI-IBS) is a new phenomenon, the prevalence of enteric infections in the ancient world renders it inevitable that this entity is far from new. All we need is the discovery of an Egyptian papyrus, Greek vase, or Roman monument that in symbol, letter, or paint depicts the development of chronic gastrointestinal symptoms after an enteric infection. That the literature on PI-IBS is so consistently modern and overwhelmingly Western is, in large part, a tribute to the recent access to accurate microbiological testing and the recognition and standardization of IBS as a diagnostic entity.


    Date de mise en ligne : Mercredi 01 mars 2017
    Michał Mazurek, Gregory Y.H. Lip
    Gastrointestinal Bleeding and Direct Oral Anticoagulants Amongst Patients With Atrial Fibrillation in the “Real World”
    The pivotal aim of oral anticoagulation in atrial fibrillation (AF) is prevention of AF-related thromboembolic strokes. The vitamin K antagonists (eg, warfarin) have been the standard of care for many years, reducing both stroke and mortality rates by 64% and 26% respectively, compared with placebo/control.1 Approval and market release of direct oral anticoagulants (DOACs; also referred to as non-vitamin K antagonist oral anticoagulants2), such as dabigatran, rivaroxaban, apixaban, and edoxaban, have changed the landscape of thromboprophylaxis substantially.


    Date de mise en ligne : Mercredi 01 mars 2017
    Neil Stollman
    The Importance of Being (Dietarily) Prudent
    What an extraordinary achievement for a civilization: to have developed the one diet that reliably makes its people sick!1


    Date de mise en ligne : Mercredi 01 mars 2017
    Exam 2: Changes in the Prevalence of Hepatitis C Virus Infection, Nonalcoholic Steatohepatitis, and Alcoholic Liver Disease Among Patients With Cirrhosis or Liver Failure on the Waitlist for Liver Transplantation


    Date de mise en ligne : Mercredi 01 mars 2017
    Exam 1: Prevalence, Risk Factors, and Outcomes of Irritable Bowel Syndrome After Infectious Enteritis: A Systematic Review and Meta-Analysis


    Date de mise en ligne : Mercredi 01 mars 2017
    Najib Nassani, Liliane Deeb, Sherif Andrawes
    An Unusual Cause of Acute Perforation
    Question: A 52-year-old woman presented to the emergency department with severe, diffuse abdominal pain of acute onset radiating to her left shoulder and neck. Her medical history was remarkable for cholecystitis and her surgical history was notable for laparoscopic cholecystectomy and C-section. On physical examination, she had diffuse tenderness and guarding. Her laboratory results showed a white count of 15,000/mm3, normal liver enzymes and a lactic acid of 2 mmol/L. A computed tomography scan of her abdomen (Figure A, B) showed free peritoneal air with lobulations around the gastric area and showed pelvic masses.


    Date de mise en ligne : Mercredi 01 mars 2017
    Koichiro Abe, Tadahisa Ebato, Takuo Tokairin
    A Pancreatic Mass Lesion
    Question: A 61-year-old woman with a 3-month history of general fatigue was referred to our hospital for detailed assessment of jaundice. Blood findings were as follows: total bilirubin, 7.47 mg/dL; aspartate aminotransferase, 164 U/L; alanine aminotransferase, 275 U/L; lactate dehydrogenase, 270 U/L; and alkaline phosphatase, 2302 U/L without elevated tumor markers. Dynamic computed tomography (CT) revealed a heterogeneous enhanced mass in the pancreatic head with a diameter of 40 mm and a smooth margin (Figure A).


    Date de mise en ligne : Mercredi 01 mars 2017
    Sukhman Shergill, Thomas C. Smyrk, Seth Sweetser
    A Malignant Mimic
    Question: A 67-year-old woman with lichen planus involving the skin was referred for evaluation of progressive solid food dysphagia for 10 years. There was a documented 10-lbs weight loss in the last 3 months. She described an increase in frequency of meats and breads sticking in the substernal area requiring liquids to facilitate food bolus passage. She had undergone annual upper endoscopies for >10 years that showed erosive esophagitis and esophageal candidiasis. A distal esophageal luminal stenosis was seen on several occasions.


    Date de mise en ligne : Mercredi 01 mars 2017
    Thomas Malikowski, Badr Al-Bawardy, Amy S. Oxentenko
    Abnormal Liver Tests and Persistent Lactic Acidosis in an 18-Year-Old Woman
    Question: An 18-year-old woman with past medical history of poorly controlled type 1 diabetes mellitus presented to the hospital with abdominal pain, nausea, vomiting, diaphoresis, and light headedness.


    Date de mise en ligne : Mardi 28 février 2017
    Sonia S. Kupfer
    Gaining Ground in the Genetics of Gastric Cancer
    Gastric cancer is the third most common malignancy worldwide.1 Outcomes are poor with 5-year survival estimates of 30% and 5% for all stages and for metastatic disease, respectively.2 Environmental factors, such as Helicobacter pylori infection, diet, and tobacco use, are strong risk factors that likely underlie many gastric cancer cases.3 In 5% to 10% of cases, there is familial clustering of gastric cancers, and, although shared environmental risk factors could explain some of this clustering, hereditary syndromes owing to genetic mutations are known to increase gastric cancer risk.


    Date de mise en ligne : Mardi 28 février 2017
    Eugene Kligman, Paul Y. Kwo
    Confirming What We Believed: Reducing and Eliminating Vertical Transmission of Hepatitis B
    Pan CQ, Duan Z, Dai E, et al. Tenofovir to prevent hepatitis B transmission in mothers with high viral load. N Engl J Med 2016;374:2324-2234.


    Date de mise en ligne : Lundi 27 février 2017
    Alessio Aghemo, Massimo Colombo
    Response-Guided Duration of Direct Acting Antiviral Therapy for Chronic Hepatitis C: Back to the Future?
    Lau G, Benhamou Y, Chen G, et al. Efficacy and safety of 3-week response-guided triple direct-acting antiviral therapy for chronic hepatitis C infection: a phase 2, open-label, proof-of-concept study. Lancet Gastroenterol Hepatol 2016;1:97–104.


    Date de mise en ligne : Dimanche 26 février 2017
    Sofia M.E. Weiler, Federico Pinna, Thomas Wolf, Teresa Lutz, Aman Geldiyev, Carsten Sticht, Maria Knaub, Stefan Thomann, Michaela Bissinger, Shan Wan, Stephanie Rössler, Diana Becker, Norbert Gretz, Hauke Lang, Frank Bergmann, Vladimir Ustiyan, Tatiana V. Kalin, Stephan Singer, Ju-Seog Lee, Jens U. Marquardt, Peter Schirmacher, Vladimir V. Kalinichenko, Kai Breuhahn
    Induction of Chromosome Instability by Activation of Yes Associated Protein and Forkhead box M1 in Liver Cancer
    Many different types of cancer cells have chromosome instability. The hippo pathway leads to phosphorylation of the transcriptional activator yes associated protein 1 (YAP1, YAP), which regulates proliferation and has been associated with development of liver cancer. We investigated the effects of hippo signaling via YAP on chromosome stability and hepatocarcinogenesis in humans and mice.


    Date de mise en ligne : Dimanche 26 février 2017
    Raaj S. Mehta, Mingyang Song, Reiko Nishihara, David A. Drew, Kana Wu, Zhi Rong Qian, Teresa T. Fung, Tsuyoshi Hamada, Yohei Masugi, Annacarolina da Silva, Yan Shi, Wanwan Li, Mancang Gu, Walter C. Willett, Charles S. Fuchs, Edward L. Giovannucci, Shuji Ogino, Andrew T. Chan
    Dietary Patterns and Risk of Colorectal Cancer: Analysis by Tumor Location and Molecular Subtypes
    Western and prudent dietary patterns have been associated with higher and lower risks of colorectal cancer (CRC), respectively. However, little is known about associations between dietary patterns and specific anatomic subsite or molecular subtypes of CRC.


    Date de mise en ligne : Samedi 25 février 2017
    Meng Zhu, Caiwang Yan, Chuanli Ren, Xiaodan Huang, Xun Zhu, Haiyong Gu, Meilin Wang, Shouyu Wang, Yong Gao, Yong Ji, Xiaoping Miao, Ming Yang, Jinfei Chen, Jiangbo Du, Tongtong Huang, Yue Jiang, Juncheng Dai, Hongxia Ma, Jianwei Zhou, Zhaoming Wang, Zhibin Hu, Guozhong Ji, Zhengdong Zhang, Hongbing Shen, Yongyong Shi, Guangfu Jin
    Exome Array Analysis Identifies Variants in SPOCD1 and BTN3A2 That Affect Risk for Gastric Cancer
    Several genetic variants have been associated with gastric cancer risk, although these account for only a fraction of gastric cancer cases. We aimed to identify low-frequency and other genetic variants that determine gastric cancer susceptibility.


    Date de mise en ligne : Samedi 25 février 2017
    Chun-Pyo Hong, Areum Park, Bo-Gie Yang, Chang Ho Yun, Min-Jung Kwak, Gil-Woo Lee, Jung-Hwan Kim, Min Seong Jang, Eun-Jung Lee, Eun-Ji Jeun, Gihoon You, Kwang Soon Kim, Youngwoo Choi, Ji-Hwan Park, Daehee Hwang, Sin-Hyeog Im, Jihyun F. Kim, Yoon-Keun Kim, Ju-Young Seoh, Charles D. Surh, You-Me Kim, Myoung Ho Jang
    Gut-specific Delivery of T-helper 17 Cells Reduces Obesity and Insulin Resistance in Mice
    Obesity and metabolic syndrome have been associated with alterations to the intestinal microbiota. However, few studies examined the effects of obesity on the intestinal immune system. We investigated changes in subsets of intestinal CD4+ T-helper (Th) cells with obesity and the effects of gut-tropic Th17 cells in mice on a high-fat diet (HFD).


    Date de mise en ligne : Vendredi 24 février 2017
    S. Lieberman, T. Walsh, M. Schechter, T. Adar, E. Goldin, R. Beeri, N. Sharon, H. Baris, L. Ben Avi, E. Half, I. Lerer, B.H. Shirts, C.C. Pritchard, I. Tomlinson, M.C. King, E. Levy-Lahad, T. Peretz, Y. Goldberg
    Features of Patients With Hereditary Mixed Polyposis Syndrome Caused by Duplication of GREM1 and Implications for Screening and Surveillance
    Hereditary mixed polyposis syndrome is a rare colon cancer predisposition syndrome caused by a duplication of a non-coding sequence near the gremlin 1, DAN family BMP antagonist gene (GREM1) originally described in Ashkenazi Jews. Few families with GREM1 duplications have been described, so there are many questions about detection and management. We report 4 extended families with the duplication near GREM1 previously found in Ashkenazi Jews; 3 families were identified at cancer genetic clinics in Israel and 1 family was identified in a cohort of patients with familial colorectal cancer.


    Date de mise en ligne : Vendredi 24 février 2017
    Zhang-Hui Chen, Yan P. Yu, Junyan Tao, Silvia Liu, George Tseng, Michael Nalesnik, Ronald Hamilton, Rohit Bhargava, Joel B. Nelson, Arjun Pennathur, Satdarshan P. Monga, James D. Luketich, George K. Michalopoulos, Jian-Hua Luo
    MAN2A1–FER Fusion Gene Is Expressed by Human Liver and Other Tumor Types and Has Oncogenic Activity in Mice
    Human tumors and liver cancer cell lines express the product of a fusion between the first 13 exons in the mannosidase α class 2A member 1 gene (MAN2A1) and the last 6 exons in the FER tyrosine kinase gene (FER), called MAN2A1−FER. We investigated whether MAN2A1−FER is expressed by human liver tumors and its role in liver carcinogenesis.


    Date de mise en ligne : Jeudi 23 février 2017
    Daniel Mønsted Shabanzadeh, Lars Tue Sørensen, Torben Jørgensen
    Association Between Screen-detected Gallstone Disease and Cancer in a Cohort Study
    In a general population screened for gallstones through ultrasound examination, gallstones were associated with the development of pooled gastrointestinal cancers and, in particular, right-side colon cancer.


    Date de mise en ligne : Jeudi 23 février 2017
    Aynur Unalp-Arida, Constance E. Ruhl, Rok Seon Choung, Tricia L. Brantner, Joseph A. Murray
    Lower Prevalence of Celiac Disease and Gluten-Related Disorders in Persons Living in Southern vs Northern Latitudes of the United States
    The association between prevalence of celiac disease and geographic region is incompletely understood, but the occurrence of several autoimmune disorders has been found to vary along a North–South gradient. We examined geographic, demographic, and clinical factors associated with prevalence of celiac disease and gluten-free diet (GFD) in the United States (US).


    Date de mise en ligne : Vendredi 17 février 2017
    Joseph C. Anderson, John A. Baron, Dennis J. Ahnen, Elizabeth L. Barry, Roberd M. Bostick, Carol A. Burke, Robert S. Bresalier, Timothy R. Church, Bernard F. Cole, Marcia Cruz-Correa, Adam S. Kim, Leila A. Mott, Robert S. Sandler, Douglas J. Robertson
    Factors Associated With Shorter Colonoscopy Surveillance Intervals for Patients With Low-risk Colorectal Adenomas and Effects on Outcome
    Endoscopists do not routinely follow guidelines to survey individuals with low-risk adenomas (LRAs, 1–2 small tubular adenomas, less than 1 cm) every 5–10 years for colorectal cancer (CRC)—many endoscopists recommend shorter surveillance intervals for these individuals. We aimed to identify reasons that endoscopists recommend shorter surveillance intervals for some individuals with LRAs and determine whether timing affects outcomes at follow-up examinations.


    Date de mise en ligne : Vendredi 17 février 2017
    Rohit Loomba, T. Jake Liang
    Hepatitis B Reactivation Associated With Immune Suppressive and Biological Modifier Therapies: Current Concepts, Management Strategies, and Future Directions
    Hepatitis B reactivation associated with immune-suppressive and biological therapies is emerging to be an important cause of morbidity and mortality in patients with current or prior exposure to hepatitis B virus (HBV) infection. The population at risk for HBV reactivation includes those who either currently are infected with HBV or have had past exposure to HBV. Because curative and eradicative therapy for HBV is not currently available, there is a large reservoir of individuals at risk for HBV reactivation in the general population.


    Date de mise en ligne : Mercredi 15 février 2017
    George Thom, Mike Lean
    "Is there an optimal diet for weight management and metabolic health?”
    Individuals can lose body weight and improve health status on a wide range of energy (calorie) restricted dietary interventions. In this paper, we have reviewed the effectiveness of the most commonly utilized diets, including low-fat, low-carbohydrate and Mediterranean approaches in addition to commercial slimming programmes, meal replacements and newly-popularized intermittent fasting diets. We also consider the role of artificial sweeteners in weight management. Low-fat diets tend to improve LDL-cholesterol most, whilst lower-carbohydrate diets may preferentially improve triglycerides and HDL-cholesterol, however differences between diets are marginal.


    Date de mise en ligne : Mercredi 15 février 2017
    Oscar Chávez-Talavera, Anne Tailleux, Philippe Lefebvre, Bart Staels
    Bile acid control of metabolism and inflammation in obesity, type 2 diabetes, dyslipidemia and NAFLD
    Bile acids are signaling molecules, which coordinately regulate metabolism and inflammation via the nuclear farnesoid X receptor (FXR) and the Takeda G protein-coupled receptor 5 (TGR5). These receptors activate transcriptional networks and signaling cascades controlling the expression and activity of genes involved in bile acid, lipid and carbohydrate metabolism, energy expenditure, and inflammation by acting predominantly in entero-hepatic tissues, but also in peripheral organs. In this review, we discuss the most recent findings on the inter-organ signaling and interplay with the gut microbiota of bile acids and their receptors in meta-inflammation, with a focus on their pathophysiological roles in obesity, type 2 diabetes, dyslipidemia and non-alcoholic steatohepatitis and their potential therapeutic applications.


    Date de mise en ligne : Mercredi 15 février 2017
    Tove Fall, Michael Mendelson, Elizabeth K. Speliotes
    Recent advances in human genetics and epigenetics of adiposity: pathway to precision medicine?
    Obesity is a heritable trait that contributes to substantial global morbidity and mortality. Here, we summarize findings from the last decade of genetic and epigenetic research focused on unravelling the underpinnings of adiposity. More than 140 genetic regions are now known to influence adiposity traits. The genetics of general adiposity, as measured by body mass index, and that of abdominal obesity, as measured by waist to hip ratio, have distinct biological backgrounds. Expression of genes associated with general adiposity are enriched in the nervous system.


    Date de mise en ligne : Lundi 13 février 2017
    Xinxin Cheng, Lixuan Wei, Xudong Huang, Jian Zheng, Mingming Shao, Ting Feng, Jun Li, Yaling Han, Wenle Tan, Wen Tan, Dongxin Lin, Chen Wu
    SLC39A6 Promotes Aggressiveness of Esophageal Carcinoma Cells by Increasing Intracellular Levels of Zinc, Activating Phosphatidylinositol 3-kinase Signaling, and Upregulating Genes That Regulate Metastasis
    A common variant in the solute carrier family 39 member 6 gene (SLC39A6) has been associated with survival times of patients with esophageal squamous-cell carcinoma (ESCC). We investigated the function of SLC39A6 and ways in which this variant affects tumor progression by studying ESCC samples and cell lines.


    Date de mise en ligne : Lundi 13 février 2017
    Kyle Staller, Mary K. Townsend, Hamed Khalili, Raaj Mehta, Francine Grodstein, William E. Whitehead, Catherine A. Matthews, Braden Kuo, Andrew T. Chan.
    Menopausal Hormone Therapy is Associated With Increased Risk of Fecal Incontinence in Women After Menopause
    Low estrogen levels could contribute to development of fecal incontinence (FI) in women after menopause by altering neuromuscular continence mechanisms. However, studies have produced conflicting results on the association between menopausal hormone therapy (MHT) and risk of FI.


    Date de mise en ligne : Vendredi 10 février 2017
    M.P. Monteiro, R.L. Batterham
    The Importance of the Gastrointestinal Tract in Controlling Food Intake and Regulating Energy Balance
    The gastrointestinal (GI) tract, the key interface between ingested nutrients and the body, plays a critical role in regulating energy homeostasis. Gut-derived signals convey information regarding incoming nutrients to the brain, initiating changes in eating behavior and energy expenditure, to maintain energy balance. Here we review hormonal, neural and nutrient signals emanating from the GI tract and evidence for their role in controlling feeding behavior. Mechanistic studies that have utilized pharmacological and/or transgenic approaches targeting an individual hormone/mediator have yielded somewhat disappointing bodyweight changes, often leading to the hormone/mediator in question being dismissed as a potential obesity therapy.


    Date de mise en ligne : Vendredi 10 février 2017
    Kevin D. Hall, Juen Guo
    Obesity Energetics: Body Weight Regulation and the Effects of Diet Composition
    Weight changes are accompanied by imbalances between calorie intake and expenditure. This fact is often misinterpreted to suggest that obesity is caused by gluttony and sloth and can be treated by simply advising people to eat less and move more. However, various components of energy balance are dynamically interrelated and weight loss is resisted by counterbalancing physiological processes. While low carbohydrate diets have been suggested to partially subvert these processes by increasing energy expenditure and promoting fat loss, our meta-analysis of 32 controlled feeding studies with isocaloric substitution of carbohydrate for fat found that both energy expenditure (26 kcal/d; p<0.0001) and fat loss (16g/d; p<0.0001) were greater with lower fat diets.


    Date de mise en ligne : Vendredi 10 février 2017
    Josep Vidal, Ricard Corcelles, Amanda Jiménez, Lílliam Flores, Antonio M. Lacy
    Metabolic and Bariatric Surgery for Obesity
    Metabolic and bariatric surgery (MBS) leads to weight loss in obese individuals and reduces comorbidities such as type 2 diabetes. MBS is superior to medical therapy in reducing hyperglycemia in persons with type 2 diabetes, and has been associated with reduced mortality and incidences of cardiovascular events and cancer in obese individuals. New guidelines have been proposed for the use of MBS in persons with type 2 diabetes. We review the use of MBS as a treatment for obesity and obesity-related conditions and, based on recent evidence, propose health care systems make the appropriate changes to increase accessibility for eligible patients.


    Date de mise en ligne : Vendredi 10 février 2017
    Ira M. Jacobson, Eric Lawitz, Paul Y. Kwo, Christophe Hézode, Cheng-Yuan Peng, Anita Y.M. Howe, Peggy Hwang, Janice Wahl, Michael Robertson, Eliav Barr, Barbara A. Haber
    Safety and Efficacy of Elbasvir/Grazoprevir in Patients With Hepatitis C Virus Infection and Compensated Cirrhosis: An Integrated Analysis
    Persons with hepatitis C virus (HCV) infection are at risk of progressive liver disease, cirrhosis, and decompensation. We analyzed the effects of the direct-acting antiviral agents elbasvir and grazoprevir in patients with HCV infection and compensated cirrhosis, combining data from 6 clinical trials.


    Date de mise en ligne : Vendredi 10 février 2017
    Chong He, Tianming Yu, Yan Shi, Caiyun Ma, Wenjing Yang, Leilei Fang, Mingming Sun, Wei Wu, Fei Xiao, Feifan Guo, Minhu Chen, Hong Yang, Jiaming Qian, Yingzi Cong, Zhanju Liu
    MicroRNA 301A Promotes Intestinal Inflammation and Colitis-Associated Cancer Development by Inhibiting BTG1
    Intestinal tissues from patients with inflammatory bowel disease (IBD) and colorectal cancer have increased expression of microRNA-301a (MIR301A) compared with tissues from patients without IBD. We studied the mechanisms of MIR301A in the progression of IBD in human tissues and mice.


    Date de mise en ligne : Vendredi 10 février 2017
    Jeffrey S. Hyams, Marla C. Dubinsky, Robert N. Baldassano, Richard B. Colletti, Salvatore Cucchiara, Johanna Escher, William Faubion, John Fell, Benjamin D. Gold, Anne Griffiths, Sibylle Koletzko, Subra Kugathasan, James Markowitz, Frank M. Ruemmele, Gigi Veereman, Harland Winter, Nicholas Masel, Chu Ri Shin, Kezhen L. Tang, Meena Thayu
    Infliximab not Associated With Increased Risk of Malignancy or Hemophagocytic Lymphohistiocytosis in Pediatric Patients With Inflammatory Bowel Disease
    Immunosuppressive therapy for inflammatory bowel disease (IBD) in pediatric patients is thought to increase risk of malignancy and lymphoproliferative disorders, including hemophagocytic lymphohistiocytosis (HLH). We compared unadjusted incidence rates and of malignancy and HLH in pediatric patients with IBD exposed to infliximab compared with patients not exposed to biologics and calculated standardized incidence ratios (SIRs).


    Date de mise en ligne : Vendredi 10 février 2017
    Corey A. Siegel
    Transforming Gastroenterology Care With Telemedicine
    Health care is changing rapidly, so we must change with the times to develop more efficient, practical, cost-effective, and, importantly, high-quality methods to care for patients. We teach medical students that optimal patient care requires face-to-face interaction to collect information on the patient’s history and perform the physical examination. However, management of many patients—especially those with chronic diseases—does not always require physical examination. Telemedicine offers an opportunity to take advantage of technology while leveraging the progressive push toward efficiency and value but also requires the belief that excellent patient care is not always provided in person.


    Date de mise en ligne : Vendredi 10 février 2017
    Michael Camilleri, Harmeet Malhi, Andres Acosta
    Gastrointestinal Complications of Obesity
    Obesity is usually associated with morbidity related to diabetes mellitus and cardiovascular diseases. However, there are many gastrointestinal and hepatic diseases for which obesity is the direct cause [e.g. non-alcoholic fatty liver diseases (NAFLD)] or is a significant risk factor, such as reflux esophagitis and gallstones. When obesity is a risk factor, it may interact with other mechanisms and result in earlier presentation or complicated diseases. There are increased odds ratios or relative risks of several gastrointestinal complications of obesity: gastroesophageal reflux disease (GERD), erosive esophagitis, Barrett’s esophagus, esophageal adenocarcinoma, erosive gastritis, gastric cancer, diarrhea, colonic diverticular disease, polyps, cancer, liver disease including NAFLD, cirrhosis, hepatocellular carcinoma, gallstones, acute pancreatitis, and pancreatic cancer.


    Date de mise en ligne : Vendredi 10 février 2017
    Sonia Caprio, Rachel Perry, Romy Kursawe
    Adolescent Obesity and Insulin Resistance: Roles of Ectopic Fat Accumulation and Adipose Inflammation
    As a consequence of the global rise in the prevalence of Adolescent Obesity, an unprecedented phenomenon of Type 2 Diabetes (T2D) has emerged in pediatrics. At the heart of T2D development lies a key metabolic derangement: Insulin Resistance (IR) . Despite the widespread occurrence of IR affecting an unmeasurable number of youths worldwide, its pathogenesis remains elusive. IR in obese youth is a complex phenomenon that defies explanation by a single pathway. In this review we first describe recent data on the prevalence, severity, and racial/ethnic differences in Pediatric Obesity.


    Date de mise en ligne : Vendredi 10 février 2017
    Hans-Rudolf Berthoud, Heike Münzberg, Christopher D. Morrison
    Blaming the brain for obesity: Integration of hedonic and homeostatic mechanisms
    The brain plays a key role in the controls of energy intake and expenditure and many genes associated with obesity are expressed in the central nervous system. Technological and conceptual advances in both basic and clinical neurosciences have expanded the traditional view of homeostatic regulation of body weight by mainly the hypothalamus to include hedonic controls of appetite by cortical and subcortical brain areas processing external sensory information, reward, cognition, and executive functions.


    Date de mise en ligne : Vendredi 10 février 2017
    Leon I. Igel, Rekha B. Kumar, Katherine H. Saunders, Louis J. Aronne
    Practical Use of Pharmacotherapy for Obesity
    Obesity management requires a multidisciplinary approach, as there are many factors that contribute to the development of obesity as well as the preservation of excess weight once it has been gained. Diet, exercise and behavior modification are key components of treatment. In addition to lifestyle changes, weight gain secondary to medications is an important modifiable risk factor. Even after appropriate lifestyle modification, and medication adjustments (where possible) to avoid agents that can contribute to weight gain, many patients are still unable to achieve clinically meaningful weight loss.


    Date de mise en ligne : Vendredi 10 février 2017
    Kristien E. Bouter, Daniël H. van Raalte, Albert K. Groen, Max Nieuwdorp
    Role of the Gut Microbiome in the Pathogenesis of Obesity and Obesity-Related Metabolic Dysfunction
    The potential role of intestinal microbiota in the etiology of various human diseases has attracted massive attention in the last decade. As such, the intestinal microbiota has been advanced as an important partaker in the development of obesity and obesity-related metabolic dysfunctions, amongst others. Experiments in animal models have produced evidence for a causal role of intestinal microbiota in the etiology of obesity and insulin resistance. However, with a few exceptions such causal relation is lacking for humans.


    Date de mise en ligne : Vendredi 10 février 2017
    N. Abate, M. Chandalia
    Risk of obesity-related cardiometabolic complications in special populations: a crisis in Asians
    The prospect of significant increase in global health-related costs associated with high cardiometabolic complications of obesity in Asians has encouraged more attention to the problem of growing obesity prevalence in these populations. While these studies have shown that cardiometabolic complications occur more frequently and at lower body mass index (BMI) in Asians than in European populations, the mechanisms involved are yet to be discovered. Ethnic/racial differences in body composition and fat distribution have been extensively studied.


    Date de mise en ligne : Vendredi 10 février 2017
    Victoria L. Webb, Thomas A. Wadden
    Intensive Lifestyle Intervention for Obesity: Principles, Practices, and Results
    Using the Guidelines for the Management of Overweight and Obesity in Adults as a framework, this article reviews intensive lifestyle interventions for weight loss. The Guidelines recommend a minimum of 6 months of high-intensity, comprehensive lifestyle intervention, consisting of a reduced-calorie diet, increased physical activity, and behavior therapy. Persons with obesity typically lose about 8 kg (approximately 8% of initial weight) with this approach, accompanied by improvements in health and quality of life.


    Date de mise en ligne : Vendredi 10 février 2017
    Shelby Sullivan, Steven A. Edmundowicz, Christopher C. Thompson
    Endoscopic Bariatric and Metabolic Therapies: New and Emerging Technologies
    Endoscopic Bariatric and Metabolic Therapies (EBMT) are a new addition to the treatment arsenal for obesity. These include devices which are placed or removed via flexible endoscopy, and procedures which utilize instruments that require flexible endoscopy for the indications of weight loss or treatment of glucose intolerance (from pre-diabetes to diabetes). The EBMTs are generally divided into gastric and small bowel categories, and although individual EBMTs may have unique mechanisms of action, similar themes in proposed mechanism of action are seen in the gastric and small bowel EBMTs respectively.


    Date de mise en ligne : Vendredi 10 février 2017
    Nicole T. Shen, Anna Maw, Lyubov L. Tmanova, Alejandro Pino, Kayley Ancy, Carl V. Crawford, Matthew S. Simon, Arthur T. Evans
    Timely use of Probiotics in Hospitalized Adults Prevents Clostridium difficile Infection: a Systematic Review with Meta-Regression Analysis
    Systematic reviews have provided evidence for the efficacy of probiotics in preventing Clostridium difficile infection (CDI), but guidelines do not recommend probiotic use for prevention of CDI. We performed an updated systematic review to help guide clinical practice.


    Date de mise en ligne : Mercredi 08 février 2017
    Nai-Ming Chen, Albrecht Neesse, Moritz Lino Dyck, Benjamin Steuber, Alexander O. Koenig, Clara Lubeseder-Martellato, Thore Winter, Teresa Forster, Hanibal Bohnenberger, Julia Kitz, Kirsten-Reuter Jessen, Heidi Griesmann, Jochen Gaedcke, Marian Grade, Jin-San Zhang, Wan-Chi Tsai, Jens Siveke, Hans-Ulrich Schildhaus, Philipp Ströbel, Steven A. Johnsen, Volker Ellenrieder, Elisabeth Hessmann
    Context-Dependent Epigenetic Regulation of Nuclear Factor of Activated T Cells 1 in Pancreatic Plasticity
    The ability of exocrine pancreatic cells to change the cellular phenotype is required for tissue regeneration upon injury, but also contributes to their malignant transformation and tumor progression. We investigated context-dependent signaling and transcription mechanisms that determine pancreatic cell fate decisions toward regeneration and malignancy. In particular, we studied the function and regulation of the inflammatory transcription factor nuclear factor of activated T cells 1 (NFATC1) in pancreatic cell plasticity and tissue adaptation.


    Date de mise en ligne : Mardi 07 février 2017
    Edwin Liu, Fran Dong, Anna E. Barón, Iman Taki, Jill M. Norris, Brigitte I. Frohnert, Edward J. Hoffenberg, Marian Rewers
    High Incidence of Celiac Disease in a Long-Term Study of Adolescents With Susceptibility Genotypes
    Little is known about the incidence of celiac disease in the general population of children in the United States. We aimed to estimate the cumulative incidence of celiac disease in adolescents born in the Denver metropolitan area.


    Date de mise en ligne : Mardi 07 février 2017
    Hidetoshi Nakagawa, Eishiro Mizukoshi, Eiji Kobayashi, Toshikatsu Tamai, Hiroshi Hamana, Tatsuhiko Ozawa, Hiroyuki Kishi, Masaaki Kitahara, Tatsuya Yamashita, Kuniaki Arai, Takeshi Terashima, Noriho Iida, Kazumi Fushimi, Atsushi Muraguchi, Shuichi Kaneko
    Association Between High-avidity T-cell Receptors, Induced by Alpha Fetoprotein-derived Peptides, and Anti-tumor Effects in Patients with Hepatocellular Carcinoma
    Levels of alpha fetoprotein (AFP) are measured for surveillance and diagnosis of hepatocellular carcinoma (HCC). We performed a phase 1 trial to evaluate the safety and efficacy of AFP-derived peptides as an anti-tumor vaccine for patients with advanced HCC, and characterized induction of AFP-specific T-cell receptors (TCRs).


    Date de mise en ligne : Vendredi 03 février 2017
    Dennis M. Jensen, Thomas OG. Kovacs, Gordon V. Ohning, Kevin Ghassemi, Gustavo A. Machicado, Gareth S. Dulai, Alireza Sedarat, Rome Jutabha, Jeffrey Gornbein
    Doppler Endoscopic Probe Monitoring of Blood Flow Improves Risk Stratification and Outcomes of Patients with Severe Non-Variceal Upper Gastrointestinal Hemorrhage
    For 4 decades, stigmata of recent hemorrhages in patients with non-variceal lesions have been used for risk stratification and endoscopic hemostasis. The arterial blood flow that underlies the stigmata is rarely monitored, but can be used to determine risk for rebleeding. We performed a randomized controlled trial to determine whether Doppler endoscopic probe monitoring of blood flow improves risk stratification and outcomes in patients with severe non-variceal upper gastrointestinal hemorrhage.


    Date de mise en ligne : Vendredi 03 février 2017
    Kentaro Matsuura, Hiromi Sawai, Kazuho Ikeo, Shintaro Ogawa, Etsuko Iio, Masanori Isogawa, Noritomo Shimada, Atsumasa Komori, Hidenori Toyoda, Takashi Kumada, Tadashi Namisaki, Hitoshi Yoshiji, Naoya Sakamoto, Mina Nakagawa, Yasuhiro Asahina, Masayuki Kurosaki, Namiki Izumi, Nobuyuki Enomoto, Atsunori Kusakabe, Eiji Kajiwara, Yoshito Itoh, Tatsuya Ide, Akihiro Tamori, Misako Matsubara, Norifumi Kawada, Ken Shirabe, Eiichi Tomita, Masao Honda, Shuichi Kaneko, Sohji Nishina, Atsushi Suetsugu, Yoichi Hiasa, Hisayoshi Watanabe, Takuya Genda, Isao Sakaida, Shuhei Nishiguchi, Koichi Takaguchi, Eiji Tanaka, Junichi Sugihara, Mitsuo Shimada, Yasuteru Kondo, Yusuke Kawai, Kaname Kojima, Masao Nagasaki, Katsushi Tokunaga, Yasuhito Tanaka, Japanese Genome-Wide Association Study Group for Viral Hepatitis
    Genome-Wide Association Study Identifies TLL1 Variant Associated With Development of Hepatocellular Carcinoma After Eradication of Hepatitis C Virus Infection
    There is still a risk for hepatocellular carcinoma (HCC) development after eradication of hepatitis C virus (HCV) infection with antiviral agents. We investigated genetic factors associated with the development of HCC in patients with a sustained virologic response (SVR) to treatment for chronic HCV infection.


    Date de mise en ligne : Dimanche 29 janvier 2017
    Jae Kwan Jun, Kui Son Choi, Hoo-Yeon Lee, Mina Suh, Boyoung Park, Seung Hoon Song, Kyu Won Jung, Chan Wha Lee, Il Ju Choi, Eun-Cheol Park, Dukhyoung Lee
    Effectiveness of the Korean National Cancer Screening Program in Reducing Gastric Cancer Mortality
    It is not clear whether screening for gastric cancer by upper endoscopy or upper gastrointestinal (UGI) series examinations (looking at the upper and middle sections of the gastrointestinal tract by imaging techniques) reduces mortality. Nevertheless, the Korean National Cancer Screening Program for gastric cancer was launched in 1999 to screen individuals 40 years and older for gastric cancer using these techniques. We evaluated the effectiveness of these techniques in gastric cancer detection and compared their effects on mortality in the Korean population.


    Date de mise en ligne : Samedi 28 janvier 2017
    Keane K.Y. Lai, Soo-Mi Kweon, Feng Chi, Edward Hwang, Yasuaki Kabe, Reiichi Higashiyama, Lan Qin, Rui Yan, Raymond P. Wu, Naoaki Fujii, Samuel French, Jun Xu, Jian-Ying Wang, Ramanchadran Murali, Lopa Mishra, Ju-Seog Lee, James M. Ntambi, Hidekazu Tsukamoto
    Stearoyl-CoA Desaturase Promotes Liver Fibrosis and Tumor Development in Mice via a Wnt Positive-Signaling Loop by Stabilization of Low-Density Lipoprotein–Receptor–Related Proteins 5 and 6
    Stearoyl-CoA desaturase (SCD) synthesizes monounsaturated fatty acids (MUFAs) and has been associated with the development of metabolic syndrome, tumorigenesis, and stem cell characteristics. We investigated whether and how SCD promotes liver fibrosis and tumor development in mice.


    Date de mise en ligne : Vendredi 27 janvier 2017
    Edward J. Gane, Robert H. Hyland, Yin Yang, Evguenia Svarovskaia, Luisa M. Stamm, Diana M. Brainard, John G. McHutchison, Catherine A.M. Stedman
    Efficacy of Ledipasvir Plus Sofosbuvir for 8 or 12 Weeks in Patients With Hepatitis C Virus Genotype 2 Infection
    Patients with chronic hepatitis C virus (HCV) genotype 2 have high rates of response to treatment with sofosbuvir and ribavirin. However, ribavirin is associated with hemolytic events and is poorly tolerated by some patients. We evaluated the effectiveness of sofosbuvir and ledipasvir in treatment-naïve and treatment-experienced patients with HCV genotype 2, comparing 12 versus 8 weeks of treatment.


    Date de mise en ligne : Jeudi 26 janvier 2017
    Michael J. Rosen, Rebekah Karns, Jefferson E. Vallance, Ramona Bezold, Amanda Waddell, Margaret H. Collins, Yael Haberman, Phillip Minar, Robert N. Baldassano, Jeffrey S. Hyams, Susan S. Baker, Richard Kellermayer, Joshua D. Noe, Anne M. Griffiths, Joel R. Rosh, Wallace V. Crandall, Melvin B. Heyman, David R. Mack, Michael D. Kappelman, James Markowitz, Dedrick E. Moulton, Neal S. Leleiko, Thomas D. Walters, Subra Kugathasan, Keith T. Wilson, Simon P. Hogan, Lee A. Denson
    Mucosal Expression of Type 2 and Type 17 Immune Response Genes Distinguishes Ulcerative Colitis From Colon-Only Crohn’s Disease in Treatment-Naive Pediatric Patients
    There is controversy regarding the role of the type 2 immune response in the pathogenesis of ulcerative colitis (UC)—few data are available from treatment-naive patients. We investigated whether genes associated with a type 2 immune response in the intestinal mucosa are up-regulated in treatment-naive pediatric patients with UC compared with patients with Crohn’s disease (CD)-associated colitis or without inflammatory bowel disease (IBD), and whether expression levels are associated with clinical outcomes.


    Date de mise en ligne : Jeudi 26 janvier 2017
    Cristina Alonso, David Fernández-Ramos, Marta Varela-Rey, Ibon Martínez-Arranz, Nicolás Navasa, Sebastiaan M. Van Liempd, José L. Lavin, Rebeca Mayo, Concetta P. Ilisso, Virginia G. de Juan, Marta Iruarrizaga-Lejarreta, Laura delaCruz-Villar, Itziar Mincholé, Aaron Robinson, Javier Crespo, Antonio Martín-Duce, Manuel Romero-Gomez, Holger Sann, Julian Platon, Jennifer Van Eyk, Patricia Aspichueta, Mazen Noureddin, Juan M. Falcón-Pérez, Juan Anguita, Ana M. Aransay, María Luz Martínez-Chantar, Shelly C. Lu, José M. Mato
    Metabolomic Identification of Subtypes of Nonalcoholic Steatohepatitis
    Nonalcoholic fatty liver disease (NAFLD) is a consequence of defects in diverse metabolic pathways that involve hepatic accumulation of triglycerides. Features of these aberrations might determine whether NAFLD progresses to nonalcoholic steatohepatitis (NASH). We investigated whether the diverse defects observed in patients with NAFLD are caused by different NAFLD subtypes with specific serum metabolomic profiles, and whether these can distinguish patients with NASH from patients with simple steatosis.


    Date de mise en ligne : Mardi 24 janvier 2017
    Vittoria Massafra, Alexandra Milona, Harmjan R. Vos, Rúben J.J. Ramos, Johan Gerrits, Ellen C.L. Willemsen, José M. Ramos Pittol, Noortje Ijssennagger, Martin Houweling, Hubertus C.M.T. Prinsen, Nanda M. Verhoeven-Duif, Boudewijn M. Burgering, Saskia W.C. van Mil
    Farnesoid X Receptor Activation Promotes Hepatic Amino Acid Catabolism and Ammonium Clearance in Mice
    The nuclear receptor subfamily 1 group H member 4 (NR1H4 or farnesoid X receptor [FXR]) regulates bile acid synthesis, transport, and catabolism. FXR also regulates postprandial lipid and glucose metabolism. We performed quantitative proteomic analyses of liver tissues from mice to evaluate these functions and investigate whether FXR regulates amino acid metabolism.


    Date de mise en ligne : Mardi 24 janvier 2017
    Gilberto Silva-Junior, Fanny Turon, Anna Baiges, Eira Cerda, Ángeles García-Criado, Annabel Blasi, Ferran Torres, Virginia Hernandez-Gea, Jaume Bosch, Juan Carlos Garcia-Pagan
    Timing Affects Measurement of Portal Pressure Gradient After Placement of Transjugular Intrahepatic Portosystemic Shunts in Patients With Portal Hypertension
    A reduction in portal pressure gradient (PPG) to <12 mm Hg after placement of a transjugular intrahepatic portosystemic shunt (TIPS) correlates with the absence of further bleeding or ascites at follow-up examinations of patients with cirrhosis. The PPG is usually measured immediately after placement of the TIPS, when different circumstances can affect PPG values, which could affect determination of risk for decompensation. We investigated variations in PPG measurements collected at different time points after TIPS, aiming to identify a time point after which PPG values were best maintained.


    Date de mise en ligne : Lundi 23 janvier 2017
    Sho Endo, Kohei Nakata, Kenoki Ohuchida, Shin Takesue, Hiromichi Nakayama, Toshiya Abe, Kazuhiro Koikawa, Takashi Okumura, Masafumi Sada, Kohei Horioka, Biao Zheng, Yusuke Mizuuchi, Chika Iwamoto, Masaharu Murata, Taiki Moriyama, Yoshihiro Miyasaka, Takao Ohtsuka, Kazuhiro Mizumoto, Yoshinao Oda, Makoto Hashizume, Masafumi Nakamura
    Autophagy Is Required for Activation of Pancreatic Stellate Cells, Associated With Pancreatic Cancer Progression and Promotes Growth of Pancreatic Tumors in Mice
    Pancreatic stellate cells (PSCs) change from a quiescent to activated state in the tumor environment and secrete extracellular matrix (ECM) molecules and cytokines to increase the aggressiveness of tumors. However, it is not clear how PSCs are activated to produce these factors, or whether this process can be inhibited. PSCs have morphologic and functional similarities to hepatic stellate cells, which undergo autophagy to promote fibrosis and tumor growth. We investigated whether autophagy activates PSCs, which promotes development of the tumor stroma and growth of pancreatic tumors in mice.


    Date de mise en ligne : Lundi 23 janvier 2017
    Ho Tsoi, Eagle S.H. Chu, Xiang Zhang, Jianqiu Sheng, Daniel Nakatsu, Siew C. Ng, Anthony W.H. Chan, Francis K.L. Chan, Joseph J.Y. Sung, Jun Yu
    Peptostreptococcus anaerobius Induces Intracellular Cholesterol Biosynthesis in Colon Cells to Induce Proliferation and Causes Dysplasia in Mice
    Stool samples from patients with colorectal cancer (CRC) have a higher abundance of Peptostreptococcus anaerobius than stool from individuals without CRC, based on metagenome sequencing. We investigated whether P anaerobius contributes to colon tumor formation in mice and its possible mechanisms of carcinogenesis.


    Date de mise en ligne : Lundi 23 janvier 2017
    Rupert W. Leong, Marie Ooi, Crispin Corte, Yunki Yau, Melissa Kermeen, Peter H. Katelaris, Charles McDonald, Meng Ngu
    Full-Spectrum Endoscopy Improves Surveillance for Dysplasia in Patients With Inflammatory Bowel Diseases
    Inflammatory bowel diseases (IBDs) increase the risk of colorectal cancer. Surveillance colonoscopy with chromoendoscopy is recommended, but conventional forward-viewing colonoscopy (FVC) detects dysplasia with low levels of sensitivity. Full-spectrum endoscopy (FUSE) incorporates 2 additional lateral cameras to the forward camera of the colonoscope, allowing endoscopists to view behind folds and in blind spots, which might increase dysplasia detection. We compared FUSE vs FVC in the detection of dysplasia in patients with IBDs.


    Date de mise en ligne : Vendredi 20 janvier 2017
    Lincon A. Stamp, Rachel M. Gwynne, Jaime P.P. Foong, Alan E. Lomax, Marlene M. Hao, David I. Kaplan, Christopher A. Reid, Steven Petrou, Andrew M. Allen, Joel C. Bornstein, Heather M. Young
    Optogenetic Demonstration of Functional Innervation of Mouse Colon by Neurons Derived From Transplanted Neural Cells
    Cell therapy offers the potential to treat gastrointestinal motility disorders caused by diseased or absent enteric neurons. We examined whether neurons generated from transplanted enteric neural cells provide a functional innervation of bowel smooth muscle in mice.


    Date de mise en ligne : Jeudi 19 janvier 2017
    Vasiliki Koliaraki, Charles K. Pallangyo, Florian R. Greten, George Kollias
    Mesenchymal Cells in Colon Cancer
    Mesenchymal cells in the intestine comprise a variety of cell types of diverse origins, functions, and molecular markers. They provide mechanical and structural support and have important functions during intestinal organogenesis, morphogenesis, and homeostasis. Recent studies of the human transcriptome have revealed their importance in the development of colorectal cancer, and studies from animal models have provided evidence for their roles in the pathogenesis of colitis-associated cancer and sporadic colorectal cancer.


    Date de mise en ligne : Samedi 14 janvier 2017
    Amber M. Moreland, Carol A. Santa Ana, John R. Asplin, Joseph A. Kuhn, Ross P. Holmes, Jason A. Cole, Elizabeth A. Odstrcil, Thomas G. Van Dinter, Juan G. Martinez, John S. Fordtran
    Steatorrhea and Hyperoxaluria in Severely Obese Patients Before and After Roux-en-Y Gastric Bypass
    Hyperoxaluria after Roux-en-Y gastric bypass (RYGB) is generally attributed to fat malabsorption. If hyperoxaluria is indeed caused by fat malabsorption, magnitudes of hyperoxaluria and steatorrhea should correlate. Severely obese patients, prior to bypass, ingest excess dietary fat that can produce hyperphagic steatorrhea. The primary objective of the study was to determine whether urine oxalate excretion correlates with elements of fat balance in severely obese patients before and after RYGB.


    Date de mise en ligne : Vendredi 13 janvier 2017
    David Goldberg, Ivo C. Ditah, Kia Saeian, Mona Lalehzari, Andrew Aronsohn, Emmanuel C. Gorospe, Michael Charlton
    Changes in the Prevalence of Hepatitis C Virus Infection, Nonalcoholic Steatohepatitis, and Alcoholic Liver Disease Among Patients With Cirrhosis or Liver Failure on the Waitlist for Liver Transplantation
    Concurrent to development of more effective drugs for treatment of hepatitis C virus (HCV) infection, there has been an increase in the incidence of nonalcoholic fatty liver disease. Data indicate that liver transplantation prolongs survival times of patient with acute hepatitis associated with alcoholic liver disease (ALD). We compared data on disease prevalence in the population with data from liver transplantation waitlists to evaluate changes in the burden of liver disease in the United States.


    Date de mise en ligne : Vendredi 13 janvier 2017
    Carl M. Schoellhammer, Gregory Y. Lauwers, Jeremy A. Goettel, Matthias A. Oberli, Cody Cleveland, June Y. Park, Daniel Minahan, Yiyun Chen, Daniel G. Anderson, Ana Jaklenec, Scott B. Snapper, Robert Langer, Giovanni Traverso
    Ultrasound-Mediated Delivery of RNA to Colonic Mucosa of Live Mice
    It is a challenge to deliver nucleic acids to gastrointestinal (GI) tissues due to their size and need for intracellular delivery. They are also extremely susceptible to degradation by nucleases, which are ubiquitous in the GI tract. We investigated whether ultrasound, which can permeabilize tissue through a phenomenon known as transient cavitation, can be used to deliver RNA to the colonic mucosa of living mice.


    Date de mise en ligne : Vendredi 13 janvier 2017
    Yoichiro Asai, Tetsuya Yamada, Sohei Tsukita, Kei Takahashi, Masamitsu Maekawa, Midori Honma, Masanori Ikeda, Keigo Murakami, Yuichiro Munakata, Yuta Shirai, Shinjiro Kodama, Takashi Sugisawa, Yumiko Chiba, Yasuteru Kondo, Keizo Kaneko, Kenji Uno, Shojiro Sawada, Junta Imai, Yasuhiro Nakamura, Hiroaki Yamaguchi, Kozo Tanaka, Hironobu Sasano, Nariyasu Mano, Yoshiyuki Ueno, Tooru Shimosegawa, Hideki Katagiri
    Activation of the Hypoxia Inducible Factor 1α Subunit Pathway in Steatotic Liver Contributes to Formation of Cholesterol Gallstones
    Hypoxia-inducible factor 1α subunit (HIF1A) is a transcription factor that controls the cellular response to hypoxia and is activated in hepatocytes of patients with nonalcoholic fatty liver disease (NAFLD). NAFLD increases the risk for cholesterol gallstone disease by unclear mechanisms. We studied the relationship between HIF1A and gallstone formation associated with liver steatosis.


    Date de mise en ligne : Lundi 09 janvier 2017
    Josepmaria Argemí, Theresia R. Kress, Haisul C.Y. Chang, Roberto Ferrero, Cristina Bértolo, Haritz Moreno, Manuela González-Aparicio, Iker Uriarte, Laura Guembe, Víctor Segura, Rubén Hernández-Alcoceba, Matías A. Ávila, Bruno Amati, Jesús Prieto, Tomás Aragón
    X-box Binding Protein 1 Regulates Unfolded Protein, Acute-Phase, and DNA Damage Responses During Regeneration of Mouse Liver
    Liver regeneration after partial hepatectomy (PH) increases the protein folding burden at the endoplasmic reticulum of remnant hepatocytes, resulting in induction of the unfolded protein response. We investigated the role of the core unfolded protein response transcription factor X-box binding protein 1 (XBP1) in liver regeneration using genome-wide chromatin immunoprecipitation analysis.


    Date de mise en ligne : Vendredi 06 janvier 2017
    Fabiane Klem, Akhilesh Wadhwa, Larry J. Prokop, Wendy J. Sundt, Gianrico Farrugia, Michael Camilleri, Siddharth Singh, Madhusudan Grover
    Prevalence, Risk Factors, and Outcomes of Irritable Bowel Syndrome After Infectious Enteritis: A Systematic Review and Meta-analysis
    Foodborne illness affects 15% of the US population each year, and is a risk factor for irritable bowel syndrome (IBS). We evaluated risk of, risk factors for, and outcomes of IBS after infectious enteritis.


    Date de mise en ligne : Jeudi 05 janvier 2017
    Lisa L. Strate, Brieze R. Keeley, Yin Cao, Kana Wu, Edward L. Giovannucci, Andrew T. Chan
    Western Dietary Pattern Increases, and Prudent Dietary Pattern Decreases, Risk of Incident Diverticulitis in a Prospective Cohort Study
    Dietary fiber is implicated as a risk factor for diverticulitis. Analyses of dietary patterns may provide information on risk beyond those of individual foods or nutrients. We examined whether major dietary patterns are associated with risk of incident diverticulitis.


    Date de mise en ligne : Jeudi 05 janvier 2017
    Jan Freark de Boer, Marleen Schonewille, Marije Boesjes, Henk Wolters, Vincent W. Bloks, Trijnie Bos, Theo H. van Dijk, Angelika Jurdzinski, Renze Boverhof, Justina C. Wolters, Jan A. Kuivenhoven, Jan M. van Deursen, Ronald P.J. Oude Elferink, Antonio Moschetta, Claus Kremoser, Henkjan J. Verkade, Folkert Kuipers, Albert K. Groen
    Intestinal Farnesoid X Receptor Controls Transintestinal Cholesterol Excretion in Mice
    The role of the intestine in the maintenance of cholesterol homeostasis increasingly is recognized. Fecal excretion of cholesterol is the last step in the atheroprotective reverse cholesterol transport pathway, to which biliary and transintestinal cholesterol excretion (TICE) contribute. The mechanisms controlling the flux of cholesterol through the TICE pathway, however, are poorly understood. We aimed to identify mechanisms that regulate and stimulate TICE.


    Date de mise en ligne : Jeudi 05 janvier 2017
    Xi-Meng Lin, Liang Hu, Jin Gu, Ruo-Yu Wang, Liang Li, Jing Tang, Bao-Hua Zhang, Xing-Zhou Yan, Yan-Jing Zhu, Cong-Li Hu, Wei-Ping Zhou, Shao Li, Jing-Feng Liu, Frank J. Gonzalez, Meng-Chao Wu, Hong-Yang Wang, Lei Chen
    Choline Kinase α Mediates Interactions Between the Epidermal Growth Factor Receptor and Mechanistic Target of Rapamycin Complex 2 in Hepatocellular Carcinoma Cells to Promote Drug Resistance and Xenograft Tumor Progression
    Choline kinase α (CHKA) catalyzes conversion of choline to phosphocholine and can contribute to carcinogenesis. Little is known about the role of CHKA in the pathogenesis of hepatocellular carcinoma (HCC).


    Date de mise en ligne : Mercredi 04 janvier 2017
    Thomas Blixt, Kim Oren Gradel, Christian Homann, Jakob Benedict Seidelin, Kristian Schønning, Anne Lester, Jette Houlind, Marie Stangerup, Magnus Gottlieb, Jenny Dahl Knudsen
    Asymptomatic Carriers Contribute to Nosocomial Clostridium difficile Infection: A Cohort Study of 4508 Patients
    Nosocomial infections with Clostridium difficile present a considerable problem despite numerous attempts by health care workers to reduce risk of transmission. Asymptomatic carriers of C difficile can spread their infection to other patients. We investigated the effects of asymptomatic carriers on nosocomial C difficile infections.


    Date de mise en ligne : Mercredi 04 janvier 2017
    Yuli Watanabe, Laure Stanchina, Laure Lecerf, Nadjet Gacem, Andrea Conidi, Viviane Baral, Veronique Pingault, Danny Huylebroeck, Nadege Bondurand
    Differentiation of Mouse Enteric Nervous System Progenitor Cells Is Controlled by Endothelin 3 and Requires Regulation of Ednrb by SOX10 and ZEB2
    Maintenance and differentiation of progenitor cells in the developing enteric nervous system are controlled by molecules such as the signaling protein endothelin 3 (EDN3), its receptor (the endothelin receptor type B [EDNRB]), and the transcription factors SRY-box 10 (SOX10) and zinc finger E-box binding homeobox 2 (ZEB2). We used enteric progenitor cell (EPC) cultures and mice to study the roles of these proteins in enteric neurogenesis and their cross regulation.


    Date de mise en ligne : Samedi 31 décembre 2016
    Nikhil Vergis, Stephen R. Atkinson, Suzanne Knapp, James Maurice, Michael Allison, Andrew Austin, Ewan H. Forrest, Steven Masson, Anne McCune, David Patch, Paul Richardson, Dermot Gleeson, Stephen D. Ryder, Mark Wright, Mark R. Thursz
    In Patients With Severe Alcoholic Hepatitis, Prednisolone Increases Susceptibility to Infection and Infection-Related Mortality, and Is Associated With High Circulating Levels of Bacterial DNA
    Infections are common in patients with severe alcoholic hepatitis (SAH), but little information is available on how to predict their development or their effects on patients. Prednisolone is advocated for treatment of SAH, but can increase susceptibility to infection. We compared the effects of infection on clinical outcomes of patients treated with and without prednisolone, and identified risk factors for development of infection in SAH.


    Date de mise en ligne : Samedi 31 décembre 2016
    Neena S. Abraham, Peter A. Noseworthy, Xiaoxi Yao, Lindsey R. Sangaralingham, Nilay D. Shah
    Gastrointestinal Safety of Direct Oral Anticoagulants: A Large Population-Based Study
    Direct oral anticoagulant (DOAC) agents increase the risk of gastrointestinal (GI) bleeding. We investigated which DOAC had the most favorable GI safety profile and compared differences among these drugs in age-related risk of GI bleeding.


    Date de mise en ligne : Samedi 31 décembre 2016
    Xiaoteng Qin, Shangming Liu, Qiulun Lu, Meng Zhang, Xiuxin Jiang, Sanyuan Hu, Jingxin Li, Cheng Zhang, Jiangang Gao, Min-Sheng Zhu, Robert Feil, Huashun Li, Min Chen, Lee S. Weinstein, Yun Zhang, Wencheng Zhang
    Heterotrimeric G Stimulatory Protein α Subunit Is Required for Intestinal Smooth Muscle Contraction in Mice
    The α subunit of the heterotrimeric G stimulatory protein (Gsa), encoded by the guanine nucleotide binding protein, α-stimulating gene (Gnas, in mice), is expressed ubiquitously and mediates receptor-stimulated production of cyclic adenosine monophosphate and activation of the protein kinase A signaling pathway. We investigated the roles of Gsa in vivo in smooth muscle cells of mice.


    Date de mise en ligne : Samedi 31 décembre 2016
    Paola Nicoletti, Guruprasad P. Aithal, Einar S. Bjornsson, Raul J. Andrade, Ashley Sawle, Marco Arrese, Huiman X. Barnhart, Emmanuelle Bondon-Guitton, Paul H. Hayashi, Fernando Bessone, Alfonso Carvajal, Ingolf Cascorbi, Elizabeth T. Cirulli, Naga Chalasani, Anita Conforti, Sally A. Coulthard, Mark J. Daly, Christopher P. Day, John F. Dillon, Robert J. Fontana, Jane I. Grove, Pär Hallberg, Nelia Hernández, Luisa Ibáñez, Gerd A. Kullak-Ublick, Tarja Laitinen, Dominique Larrey, M. Isabel Lucena, Anke H. Maitland-van der Zee, Jennifer H. Martin, Mariam Molokhia, Munir Pirmohamed, Elizabeth E. Powell, Shengying Qin, Jose Serrano, Camilla Stephens, Andrew Stolz, Mia Wadelius, Paul B. Watkins, Aris Floratos, Yufeng Shen, Matthew R. Nelson, Thomas J. Urban, Ann K. Daly, International Drug-Induced Liver Injury Consortium, Drug-Induced Liver Injury Network Investigators, and International Serious Adverse Events Consortium
    Association of Liver Injury From Specific Drugs, or Groups of Drugs, With Polymorphisms in HLA and Other Genes in a Genome-Wide Association Study
    We performed a genome-wide association study (GWAS) to identify genetic risk factors for drug-induced liver injury (DILI) from licensed drugs without previously reported genetic risk factors.


    Date de mise en ligne : Vendredi 23 décembre 2016
    Ruta Sahasrabudhe, Paul Lott, Mabel Bohorquez, Ted Toal, Ana P. Estrada, John J. Suarez, Alejandro Brea-Fernández, José Cameselle-Teijeiro, Carla Pinto, Irma Ramos, Alejandra Mantilla, Rodrigo Prieto, Alejandro Corvalan, Enrique Norero, Carolina Alvarez, Teresa Tapia, Pilar Carvallo, Luz M. Gonzalez, Alicia Cock-Rada, Angela Solano, Florencia Neffa, Adriana Della Valle, Chris Yau, Gabriela Soares, Alexander Borowsky, Nan Hu, Li-Ji He, Xiao-You Han, Latin American Gastric Cancer Genetics Collaborative Group, Philip R. Taylor, Alisa M. Goldstein, Javier Torres, Magdalena Echeverry, Clara Ruiz-Ponte, Manuel R. Teixeira, Luis G. Carvajal-Carmona
    Germline Mutations in PALB2, BRCA1, and RAD51C, Which Regulate DNA Recombination Repair, in Patients With Gastric Cancer
    Up to 10% of cases of gastric cancer are familial, but so far, only mutations in CDH1 have been associated with gastric cancer risk. To identify genetic variants that affect risk for gastric cancer, we collected blood samples from 28 patients with hereditary diffuse gastric cancer (HDGC) not associated with mutations in CDH1 and performed whole-exome sequence analysis. We then analyzed sequences of candidate genes in 333 independent HDGC and non-HDGC cases. We identified 11 cases with mutations in PALB2, BRCA1, or RAD51C genes, which regulate homologous DNA recombination.


    Date de mise en ligne : Jeudi 22 décembre 2016
    Bishnu P. Joshi, Zhenzhen Dai, Zhenghong Gao, Jeong Hoon Lee, Navin Ghimire, Jing Chen, Anoop Prabhu, Erik J. Wamsteker, Richard S. Kwon, Grace H. Elta, Elena M. Stoffel, Asha Pant, Tonya Kaltenbach, Roy M. Soetikno, Henry D. Appelman, Rork Kuick, D. Kim Turgeon, Thomas D. Wang
    Detection of Sessile Serrated Adenomas in the Proximal Colon Using Wide-Field Fluorescence Endoscopy
    Many cancers in the proximal colon develop via from sessile serrated adenomas (SSAs), which have flat, subtle features that are difficult to detect with conventional white-light colonoscopy. Many SSA cells have the V600E mutation in BRAF. We investigated whether this feature could be used with imaging methods to detect SSAs in patients.


    Date de mise en ligne : Jeudi 22 décembre 2016
    Lucas C. Duits, Myrtle J. van der Wel, Cary C. Cotton, K. Nadine Phoa, Fiebo J.W. ten Kate, Cees A. Seldenrijk, G. Johan A. Offerhaus, Mike Visser, Sybren L. Meijer, Rosalie C. Mallant-Hent, Kausilia K. Krishnadath, Roos E. Pouw, Jan G.P. Tijssen, Nicholas J. Shaheen, Jacques J.G.H.M. Bergman
    Patients With Barrett’s Esophagus and Confirmed Persistent Low-Grade Dysplasia Are at Increased Risk for Progression to Neoplasia
    For patients with Barrett’s esophagus, the diagnosis of low-grade dysplasia (LGD) is subjective, and reported outcomes vary. We analyzed data from a multicenter study of endoscopic therapy to identify factors associated with progression to high-grade dysplasia (HGD) or esophageal adenocarcinoma (EAC) in patients with LGD of the esophagus.


    Date de mise en ligne : Lundi 19 décembre 2016
    Carmelo Scarpignato, Werner Dolak, Angel Lanas, Peter Matzneller, Cecilia Renzulli, Maria Grimaldi, Markus Zeitlinger, Ingvar Bjarnason
    Rifaximin Reduces the Number and Severity of Intestinal Lesions Associated With Use of Nonsteroidal Anti-Inflammatory Drugs in Humans
    The intestinal microbiota might contribute to enteropathy associated with use of nonsteroidal anti-inflammatory drugs (NSAIDs), but there have been few human studies of this association. We performed a placebo-controlled study to determine whether a delayed-release antibiotic formulation (rifaximin-extended intestinal release [EIR]) prevents the development of intestinal lesions in subjects taking daily NSAIDs. Sixty healthy volunteers (median age, 26 y; 42% female) were given the NSAID diclofenac (75 mg twice daily) plus omeprazole (20 mg once daily), and either rifaximin-EIR (400 mg) or placebo, twice daily for 14 days.


    Date de mise en ligne : Vendredi 16 décembre 2016
    Victor F. Zevallos, Verena Raker, Stefan Tenzer, Carolina Jimenez-Calvente, Muhammad Ashfaq-Khan, Nina Rüssel, Geethanjali Pickert, Hansjörg Schild, Kerstin Steinbrink, Detlef Schuppan
    Nutritional Wheat Amylase-Trypsin Inhibitors Promote Intestinal Inflammation via Activation of Myeloid Cells
    Wheat amylase-trypsin inhibitors (ATIs) are nutritional activators of innate immunity, via activation of the toll-like receptor 4 (TLR4) on myeloid cells. We aimed to characterize the biologic activity of ATIs in various foods and their effect on intestinal inflammation.


    Date de mise en ligne : Mercredi 14 décembre 2016
    Prashanthi N. Thota, Prashanth Vennalaganti, Sreekar Vennelaganti, Patrick Young, Srinivas Gaddam, Neil Gupta, David Lieberman, Richard Sampliner, Gary W. Falk, Sharad Mathur, Kevin Kennedy, Brooks D. Cash, Fouad Moawad, Ajay Bansal, Manon C. Spaander, Marco J. Bruno, John Vargo, Prateek Sharma
    Low Risk of High-Grade Dysplasia or Esophageal Adenocarcinoma Among Patients With Barrett's Esophagus Less Than 1 cm (Irregular Z Line) Within 5 Years of Index Endoscopy
    Many patients with a < 1 cm segment of columnar metaplasia in the distal esophagus, also called an irregular Z line, are encountered. These patients, often referred to as patients with Barrett’s esophagus (BE), are enrolled in surveillance programs. However, little is known about their risk of high-grade dysplasia (HGD) or esophageal adenocarcinoma (EAC). We aimed to determine the incidence of HGD and EAC in patients with irregular Z line with intestinal metaplasia.


    Date de mise en ligne : Vendredi 09 décembre 2016
    Su Yeon An, Yu Jin Jang, Hee-Joung Lim, Jiyou Han, Jaehun Lee, Gyunggyu Lee, Ji Young Park, Seo-Young Park, Ji Hyang Kim, Byung-Rok Do, Choongseong Han, Hee-Kyung Park, Ok-Hee Kim, Myeong Jun Song, Say-June Kim, Jong-Hoon Kim
    Milk Fat Globule-EGF Factor 8, Secreted by Mesenchymal Stem Cells, Protects Against Liver Fibrosis in Mice
    Mesenchymal stem cells (MSCs) mediate tissue repair and might be used to prevent or reduce liver fibrosis. However, little is known about the anti-fibrotic factors secreted from MSCs or their mechanisms.


    Date de mise en ligne : Vendredi 09 décembre 2016
    Chun-Qing Song, Yingxiang Li, Haiwei Mou, Jill Moore, Angela Park, Yotsawat Pomyen, Soren Hough, Zachary Kennedy, Andrew Fischer, Hao Yin, Daniel G. Anderson, Darryl Conte, Lars Zender, Xin Wei Wang, Snorri Thorgeirsson, Zhiping Weng, Wen Xue
    Genome-Wide CRISPR Screen Identifies Regulators of Mitogen-Activated Protein Kinase as Suppressors of Liver Tumors in Mice
    It has been a challenge to identify liver tumor suppressors or oncogenes due to the genetic heterogeneity of these tumors. We performed a genome-wide screen to identify suppressors of liver tumor formation in mice, using CRISPR-mediated genome editing.


    Date de mise en ligne : Mardi 18 octobre 2016
    Douglas J. Robertson, Jeffrey K. Lee, C. Richard Boland, Jason A. Dominitz, Francis M. Giardiello, David A. Johnson, Tonya Kaltenbach, David Lieberman, Theodore R. Levin, Douglas K. Rex
    Recommendations on Fecal Immunochemical Testing to Screen for Colorectal Neoplasia: A Consensus Statement by the US Multi-Society Task Force on Colorectal Cancer
    The use of the fecal occult blood test (FOBT) for colorectal cancer (CRC) screening is supported by randomized trials demonstrating effectiveness in cancer prevention and widely recommended by guidelines for this purpose. The fecal immunochemical test (FIT), as a direct measure of human hemoglobin in stool has a number of advantages relative to conventional FOBT and is increasingly used relative to that test. This review summarizes current evidence for FIT in colorectal neoplasia detection and the comparative effectiveness of FIT relative to other commonly used CRC screening modalities.


    Date de mise en ligne : Mercredi 04 février 2015
    David T. Rubin
    The Rationale and Growth of Advanced Training in Inflammatory Bowel Disease


    Date de mise en ligne : Lundi 17 novembre 2014
    Steven F. Moss
    The Great Ulcer War: How It All Happened
    All gastroenterologists, most physicians, and many members of the general public are familiar with the discovery of gastric spiral bacteria in Western Australia in the early 1980s and the struggle to convince us that these bacteria, which we now call Helicobacter pylori, were a significant clinical issue. The eventual acceptance of Marshall and Warrren’s ideas resulted in their receiving the Nobel Prize for Medicine or Physiology in 2005. In contrast with the success story of triumph over adversity of these Antipodean pioneers that has been well-disseminated in the medical and lay media, little has been written about why the United States was particularly slow to accept the infectious theory of peptic ulcers.


    Date de mise en ligne : Lundi 19 novembre 2012
    Continuing Medical Education Answers: January 2013


    Date de mise en ligne : Lundi 15 octobre 2012
    Continuing Medical Education Answers: December 2012


    Date de mise en ligne : Mercredi 19 septembre 2012
    Ilaria Russo, Alessandro Luciani, Edoardo Troncone, Carolina Ciacci
    WITHDRAWN: The Endoplasmic Reticulum Stress Response Activates Tissue Transglutaminase and Intestinal Inflammation by Reducing Levels of IκBα
    This article has been withdrawn at the request of the authors. The Publisher apologizes for any inconvenience this may cause.The full Elsevier Policy on Article Withdrawal can be found at (http://www.elsevier.com/locate/withdrawalpolicy.


    Date de mise en ligne : Mercredi 22 août 2012
    Continuing Medical Education Answers: October 2012


    Date de mise en ligne : Jeudi 01 janvier 1970
    Information for Authors and Readers
    Gastroenterology is the premiere journal in the field of gastrointestinal disease and is led by an internationally renowned board of editors. As the official journal of the AGA Institute, Gastroenterology delivers up-to-date and authoritative coverage of both basic and clinical gastroenterology and hepatology. Regular features include research and perspectives by leading authorities, reports on the latest technologies for diagnosing and treating digestive diseases, images illustrating important clinical findings, reviews of scholarly media, medical news, meeting summaries, video abstracts, and monthly podcasts.


    Date de mise en ligne : Jeudi 01 janvier 1970
    Table of Contents


    Date de mise en ligne : Jeudi 01 janvier 1970
    Editorial Board


    Date de mise en ligne : Jeudi 01 janvier 1970
    Cover 1