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Les derniers abstracts de la revue Gastroenterology :


    Date de mise en ligne : Samedi 16 septembre 2017
    Joseph C. Anderson, Lynn F. Butterly, Christina M. Robinson, Julia E. Weiss, Christopher Amos, Amitabh Srivastava
    Risk of Metachronous High-risk Adenomas and Large Serrated Polyps in Individuals With Serrated Polyps on Index Colonoscopy: Data from the New Hampshire Colonoscopy Registry
    Surveillance guidelines for serrated polyps (SPs) are based on limited data on longitudinal outcomes of patients. We used the New Hampshire Colonoscopy Registry to evaluate risk of clinically important metachronous lesions associated with SPs, detected during index colonoscopies.


    Date de mise en ligne : Vendredi 15 septembre 2017
    Kezhong Zhang, Hyunbae Kim, Zhiyao Fu, Yining Qiu, Zhao Yang, Jiemei Wang, Deqiang Zhang, Xin Tong, Lei Yin, Jing Li, Jianmei Wu, Nathan R. Qi, Sander M. Houten, Ren Zhang
    Deficiency of the Mitochondrial NAD Kinase Causes Stress-induced hepatic steatosis in mice
    The mitochondrial nicotinamide adenine dinucleotide (NAD) kinase (NADK2, also called MNADK) catalyzes phosphorylation of NAD to yield NADP. Little is known about the functions of mitochondrial NADP and MNADK in liver physiology and pathology. We investigated the effects of reduced mitochondrial NADP by deleting MNADK in mice.


    Date de mise en ligne : Vendredi 15 septembre 2017
    Jianguang Ji, Jan Sundquist, Kristina Sundquist
    Cholera Vaccine Use Is Associated with a Reduced Risk of Death in Patients with Colorectal Cancer: A Population-based Study
    Cholera toxin can act as a modulator of the immune response with anti-inflammatory effects; it reduces development of colon polyps in mouse models of colorectal cancer (CRC). We performed a population-based study to determine whether, in patients with a diagnosis of CRC, subsequent administration of the cholera vaccine (killed Vibrio cholerae O1 whole cells and recombinant cholera toxin B subunit) affects mortality.


    Date de mise en ligne : Vendredi 15 septembre 2017
    Lars H. Engelholm, Anjum Riaz, Denise Serra, Frederik Dagnæs-Hansen, Jens V. Johansen, Eric Santoni-Rugiu, Steen H. Hansen, Francesco Niola, Morten Frödin
    CRISPR/Cas9 Engineering of Adult Mouse Liver Demonstrates That the Dnajb1–Prkaca Gene Fusion is Sufficient to Induce Tumors Resembling Fibrolamellar Hepatocellular Carcinoma
    Fibrolamellar hepatocellular carcinoma (FL-HCC) is a primary liver cancer that predominantly affects young adults with no underlying liver disease. A somatic, 400 Kb deletion on chromosome 19 that fuses part of the DnaJ heat shock protein family (Hsp40) member B1 gene (DNAJB1) to the protein kinase cAMP-activated catalytic subunit alpha gene (PRKACA) has been repeatedly identified in patients with FL-HCC. However, the DNAJB1–PRKACA gene fusion has not been shown to induce liver tumorigenesis. We used the CRISPR/Cas9 technique to delete in mice the syntenic region on chromosome 8 to create a Dnajb1–Prkaca fusion and monitored the mice for liver tumor development.


    Date de mise en ligne : Vendredi 15 septembre 2017
    Georg Beyer, Ujjwal M. Mahajan, Christoph Budde, Thomas J. Bulla, Thomas Kohlmann, Louise Kuhlmann, Kerstin Schütte, Ali A. Aghdassi, Eckhard Weber, Ulrich Weiss, Asbjørn M. Drewes, Søren S. Olesen, Markus M. Lerch, Julia Mayerle
    Development and Validation of a Chronic Pancreatitis Prognosis Score in 2 Independent cohorts
    The clinical course of chronic pancreatitis is unpredictable. There is no model to assess disease severity or progression or predict patient outcomes.


    Date de mise en ligne : Vendredi 15 septembre 2017
    Tamika S. Jaswani, Douglas J. Grider, M. Jonathan Bern
    A life-threatening cause of colitis


    Date de mise en ligne : Vendredi 15 septembre 2017
    Jian Chen, Sobia Zaidi, Shuyun Rao, Jiun-Sheng Chen, Liem Phan, Patrizia Farci, Xiaoping Su, Kirti Shetty, Jon White, Fausto Zamboni, Xifeng Wu, Asif Rashid, Nagarajan Pattabiraman, Raja Mazumder, Anelia Horvath, Ray-Chang Wu, Shulin Li, Cuiying Xiao, Chu-Xia Deng, David A. Wheeler, Bibhuti Mishra, Rehan Akbani, Lopa Mishra
    Analysis of Genomes and Transcriptomes of Hepatocellular Carcinomas Identifies Mutations and Gene Expression Changes in the Transforming Growth Factor beta Pathway Short title: Prognostic significance of TGF-β signature in liver cancer
    Development of hepatocellular carcinoma (HCC) is associated with alterations in the transforming growth factor beta (TGFβ) signaling pathway, which regulates liver inflammation and can have tumor suppressor or promoter activities. Little is known about the roles of specific members of this pathway at specific of HCC development. We took an integrated approach to identify and validate the effects of changes in this pathway in HCC and identify therapeutic targets.


    Date de mise en ligne : Mercredi 13 septembre 2017
    Anna S. Gukovskaya, Ilya Gukovsky, Hana Algül, Aida Habtezion
    Autophagy, Inflammation, and Immune Dysfunction in the Pathogenesis of Pancreatitis
    Pancreatitis is a common disorder with significant morbidity and mortality, yet little is known about its pathogenesis and there is no specific or effective treatment. Its development involves dysregulated autophagy and unresolved inflammation, demonstrated by studies in genetic and experimental mouse models. Disease severity depends on whether the inflammatory response resolves or amplifies, leading to multi-organ failure. Dysregulated autophagy might promote the inflammatory response in the pancreas.


    Date de mise en ligne : Lundi 11 septembre 2017
    Huey-Huey Chua, Hung-Chieh Chou, Ya-Ling Tung, Bor-Luen Chiang, Chien-Chia Liao, Hong-Hsing Liu, Yen-Hsuan Ni
    Intestinal Dysbiosis Featuring Abundance of Ruminococcus gnavus Associates With Allergic Diseases in Infants
    Dysbiosis of the intestinal microbiota has been associated with development of allergies in infants. However, it is not clear what microbes might contribute to this process. We investigated what microbe(s) might be involved in analyses of infant twins and mice.


    Date de mise en ligne : Lundi 11 septembre 2017
    Fernando Bellido, Nadine Sowada, Pilar Mur, Conxi Lázaro, Tirso Pons, Rafael Valdés-Mas, Marta Pineda, Gemma Aiza, Silvia Iglesias, José Luís Soto, Miguel Urioste, Trinidad Caldés, Milagros Balbín, Pilar Blay, Daniel Rueda, Mercedes Durán, Alfonso Valencia, Victor Moreno, Joan Brunet, Ignacio Blanco, Matilde Navarro, George A. Calin, Guntram Borck, Xose S. Puente, Gabriel Capellá, Laura Valle
    Association Between Germline Mutations in BRF1, a subunit of the RNA Polymerase III Transcription Complex, and Hereditary Colorectal Cancer
    Although there is a genetic predisposition to colorectal cancer (CRC), few of the genes that affect risk have been identified. We performed whole-exome sequence analysis of individuals in a high-risk family without mutations in genes previously associated with CRC risk to identify variants associated with inherited CRC.


    Date de mise en ligne : Lundi 11 septembre 2017
    Laura Anselmi, Luca Toti, Cecilia Bove, Jessica Hampton, R. Alberto Travagli
    A Nigro-Vagal Pathway Controls Gastric Motility and is Affected in a Rat Model of Parkinsonism
    In most patients with Parkinson’s disease, gastrointestinal (GI) dysfunctions, such as gastroparesis and constipation, are prodromal to the cardinal motor symptoms of the disease. Sporadic Parkinson’s disease has been proposed to develop following ingestion of neurotoxicants that affect the brain–gut axis via the vagus nerve, and then travel to higher centers compromising the substantia nigra pars compacta (SNpc), and, later, the cerebral cortex. We aimed to identify the pathway that connects the brainstem vagal nuclei and the SNpc, and to determine whether this pathway is compromised in a rat model of Parkinsonism.


    Date de mise en ligne : Lundi 11 septembre 2017
    Mohamad El-Zaatari, Adam J. Bass, Reanne Bowlby, Min Zhang, Li-Jyun Syu, Yitian Yang, Helmut Grasberger, Andrew Shreiner, Bei Tan, Shrinivas Bishu, Wai K. Leung, Andrea Todisco, Nobuhiko Kamada, Marilia Cascalho, Andrzej A. Dlugosz, John Y. Kao
    Indoleamine 2,3-dioxygenase 1, Increased in Human Gastric Pre-Neoplasia, Promotes Inflammation and Metaplasia in Mice and is Associated with Type II Hypersensitivity/Autoimmunity
    Chronic gastrointestinal inflammation increases the risk of cancer by mechanisms that are not well understood. Indoleamine-2,3-dioxygenase 1 (IDO1) is a heme-binding enzyme that regulates the immune response via catabolization and regulation of tryptophan availability for immune cell uptake. IDO1 expression is increased during the transition from chronic inflammation to gastric metaplasia. We investigated whether IDO1 contributes to the inflammatory response that mediates loss of parietal cells leading to metaplasia.


    Date de mise en ligne : Samedi 09 septembre 2017
    Abhilash Perisetti, Debdeep Banerjee, Benjamin Tharian
    Clinical Challenges and Images in Gastroenterology: “Endoscopic Resection of Esophageal Mucosal Bridge”


    Date de mise en ligne : Samedi 09 septembre 2017
    Varun Kesar, Arun Swaminath
    Hepatic masses in a patient in Inflammatory bowel disease


    Date de mise en ligne : Samedi 09 septembre 2017
    Mohamad A. Mouchli, Paul J. Kurtin, Nicholas F. LaRusso
    A 59-Year-Old Man with New Jaundice


    Date de mise en ligne : Mercredi 06 septembre 2017
    Exam 3: Risk of Hepatocellular Cancer in HCV Patients Treated with Direct Acting Antiviral Agents


    Date de mise en ligne : Mercredi 06 septembre 2017
    Exam 2: Association Between Proton Pump Inhibitor Use and Cognitive Function in Women


    Date de mise en ligne : Mercredi 06 septembre 2017
    Exam 1: 3D Cross-Sectional Imaging of the Inflamed Gut With Light Sheet Fluorescence Microscopy for Translational Research in IBD


    Date de mise en ligne : Mercredi 06 septembre 2017
    Young Joo Yang, Jae Young Park, Chang Seok Bang
    Acute Right Upper Quadrant Abdominal Pain
    Question: A 19-year-old man without any medical history of interest was admitted to the emergency room with right upper quadrant abdominal pain. The abdominal pain had started 1 day before admission and was becoming worse. At admission, fever and chills were not present; his vital signs were normal: heart rate 68 beats/min, respiratory rate 18 breaths/min, and blood pressure 120/60 mm Hg.


    Date de mise en ligne : Mardi 05 septembre 2017
    Naga P. Chalasani, David W. Crabb, Douglas K. Rex
    In Memoriam—Lawrence Lumeng, MD: Researcher, Clinician, Leader, Mentor, Family Man, and Friend
    It is with profound sadness that we note the loss of Dr Lawrence Lumeng who passed away on June 21, 2017, at age 77, following a long battle against progressive pulmonary fibrosis that was triggered by a viral lung infection in 2004. As a founding member of the Indiana Alcohol Center he made numerous seminal contributions to the field of alcoholism, alcohol metabolism, and alcoholic liver disease.


    Date de mise en ligne : Lundi 04 septembre 2017
    Edward L. Barnes, Hans H. Herfarth
    The Usefulness of Serologic Testing for Epstein–Barr Virus Before Initiation of Therapy for Inflammatory Bowel Disease
    We read with great interest the recent study by Hyams et al1 evaluating the risk of malignancy or hemophagocytic lymphohistiocytosis (HLH) in pediatric patients with inflammatory bowel disease (IBD) treated with infliximab. Although the authors demonstrated no increased risk of malignancy or HLH among pediatric patients treated with infliximab when evaluated by standardized incidence ratios, the use of thiopurines was associated with an increased risk of malignancy and HLH. Although we appreciate the significance of any increased risk for development of malignancy or lymphoproliferative disease among pediatric patients, we were very intrigued by the overall rarity of HLH and malignancy cases particularly as these conditions relate to exposure to Epstein–Barr virus (EBV).


    Date de mise en ligne : Lundi 04 septembre 2017
    Stacy Chapman, Wael El-Matary
    Screening for Epstein–Barr Virus Status and Risk of Hemophagocytic Lymphohistiocytosis in Children With Inflammatory Bowel Disease on Azathioprine
    Thiopurines have been mainly used to maintain remission in patients with inflammatory bowel disease (IBD) for decades, especially since the landmark placebo-controlled double blind randomized study by Markowitz et al.1 However, adverse events, especially cancer risk, remain a concern.2 The use of thiopurines in Epstein-Barr virus (EBV)–naïve patients with IBD has been questioned owing to the potential risk of hemophagocytic lymphohistiocytosis (HLH).3


    Date de mise en ligne : Lundi 04 septembre 2017
    Lindsey M. Childs-Kean, Joseph Hong
    Detectable Viremia at the End of Treatment With Direct-Acting Antivirals Can Be Associated With Subsequent Clinical Cure in Patients With Chronic Hepatitis C: A Case Series
    We report a case series of 5 patients with quantifiable viral loads at the end of treatment who subsequently achieved sustained virologic response (SVR) with recommended hepatitis C virus (HCV) direct-acting antiviral (DAA) regimens. All 5 patients had HCV genotype 1a, were male, and none were coinfected with human immunodeficiency virus. Their ages ranged from 56 to 67 years. All patients had a baseline viral load between 2,000,000 and 7,000,000 IU/mL (Table 1). Three of the patients received 8 weeks of ledipasvir/sofosbuvir (LDV/SOF), one received 12 weeks of LDV/SOF, and one received 12 weeks of paritaprevir/ritonavir/ombitasvir/dasabuvir with ribavirin (PrOD+RBV).


    Date de mise en ligne : Lundi 04 septembre 2017
    Peter R. Holt
    Steatorrhea, Hyperoxaluria and Colonic Hyperproliferation after Roux-en-Y Gastric Bypass
    In their recent paper, Moreland et al1 showed that obese patients after Roux-en-Y gastric bypass surgery have steatorrhea and hyperoxaluria that were quantitatively correlated. They appropriately explained that hyperoxaluria was due to excess fatty acids in the colon of these patients. Within the colonic lumen, fatty acids and oxalic acids both are present in ionic form and thus are able to be absorbed by the epithelium. After absorption, oxalic acid is excreted in the urine and fatty acids can be injurious to colonic epithelial cells.


    Date de mise en ligne : Lundi 04 septembre 2017
    Chuncheng Wu, Mei Xu
    A Huge Changing Mass in the Esophagus
    Question: A 60-year-old man presented with substernal chest pain and dysphagia lasting 1 month. The intensity of substernal chest pain increased when swallowing food without chills and fever. He had lost about 4.0 kg in the past 2 months.


    Date de mise en ligne : Lundi 04 septembre 2017
    Julien Rohmer, Romain Paule, Benjamin Terrier
    A Severe But Easily Treatable Dysphagia
    Question: A 31-year-old woman, born in Pakistan, presented with dysphagia and severe anemia. She had a 10-year history of iron deficiency anemia secondary to chronic menorrhagia. She initially received a red blood cell transfusion, but had no gynecologic explorations or follow-up. The patient complained of dysphagia for solids that had been worsening for the last 5 years associated with a weight loss of 10 kg, but not with odynophagia or dysphonia. At admission, her hemoglobin level was 55 g/L, with a low mean corpuscular volume (70 fL) and ferritin level (<10 μg/L).


    Date de mise en ligne : Lundi 04 septembre 2017
    Chi-Ying Yang, Ken-Sheng Cheng
    An Unusual Case of Liver Tumor
    Question: A 60-year-old man with thalassemia presented with progressive right upper quadrant abdominal pain of 1 month’s duration. The pain was persistent, dullness and did not any radiate or migrate pain. There was no hepatitis B or C virus infection. The physical examination showed mild right upper quadrant tenderness. Laboratory tests revealed hemoglobin, 8.6 g/dL (normal, 14-16); alanine transaminase, 32 IU/L (normal, 5-40); alkaline phosphatase, 142 IU/L (normal, 38-126); and total bilirubin, 0.6 (normal, 0.2-1.3).


    Date de mise en ligne : Lundi 04 septembre 2017
    Tossapol Kerdsirichairat, Eun-Young K. Choi, William D. Chey
    An Atypical Coincidence of Colon Ischemia and Bilateral Distal Ureteral Strictures
    Question: A 67-year-old man with a past medical history of well-controlled diabetes mellitus type 2, a recent episode of acute kidney injury owing to bilateral distal ureteral strictures of unknown etiology treated with bilateral ureteral stenting and percutaneous nephrostomy tube placement, and a remote history of adenocarcinoma of the gastric cardia, presented with a 27-pound weight loss, worsening lower abdominal pain, and change in stool for 2 weeks. Two years before the current presentation, he had been diagnosed with invasive adenocarcinoma (Figure A) of the gastric cardia (Seifert type 3) arising in a background of Helicobacter pylori gastritis with intestinal metaplasia following presentation with melena, for which he received neoadjuvant chemotherapy with epirubicin, cisplatin, and capecitabine, followed by total gastrectomy and Roux-en-Y esophagojejunostomy reconstruction (pathology showed the depth of invasion at muscularis mucosa, negative margins, and no lymph node metastasis), and postoperative chemotherapy with the same regimen.


    Date de mise en ligne : Lundi 04 septembre 2017
    Jérôme Razanamahery, Anthony Jacquier, Sébastien Humbert
    A Rare Case of Chylous Ascites
    Question: A 68-year-old woman was admitted to the internal medicine unit for exploration of chylous ascites and retroperitoneal fibrosis. She had no medical history except recurrent bronchitis. Her medical story began 3 months earlier with an acute onset of lower limb edema treated with furosemide followed by increase in waist circumference.


    Date de mise en ligne : Lundi 04 septembre 2017
    Yuji Eso, Masako Mishima, Akihisa Fukuda
    An Unusual Cause of Hepatic Dysfunction
    Question: A 73-year-old man presented with a 7-day history of fever. He also had a history of follicular lymphoma originating from the spleen and underwent splenectomy 12 years ago. In addition, he underwent transurethral resection of a bladder tumor 8 months ago, followed by 2 rounds of bacillus Calmette-Guérin (BCG) therapy. The last course was administered 7 days before presentation. Results of laboratory analysis showed increased levels of alanine transaminase (254 IU/L; normal, <40), aspartate aminotransferase (240 IU/L; normal, <40), γ-glutamyl transpeptidase (386 IU/L; normal, <70), and alkaline phosphatase (1704 IU/L; normal, 115-359).


    Date de mise en ligne : Lundi 04 septembre 2017
    N. Jewel Samadder, Randall W. Burt, Reha M. Toydemir
    Developmental Delay and Colon Polyposis
    Question: A 20-year-old man presented to our clinic with a 3-year history of intermittent hematochezia, in addition to developmental delay. Laboratory analysis and physical examination were otherwise normal. Colonoscopy to investigate the cause of hematochezia revealed >100 tubular, tubulovillous, and villous adenomas throughout the colon, up to 2 cm in size (Figure A). Restorative proctocolectomy was performed and numerous polyps were found, but no evidence of invasive carcinoma was identified. The parents and the patient’s sibling were phenotypically normal, with no developmental delay and no family history of gastrointestinal cancer.


    Date de mise en ligne : Lundi 04 septembre 2017
    Feng Yang, Chen Jin, Deliang Fu
    A Rare Cause of Severe Hypokalemia and Back Pain
    Question: A 63-year-old man with a past medical history of hypertension presented with increasing lower extremity edema, persistent hypokalemia, and back pain for >2 months. Despite administration of spironolactone together with intravenous and oral potassium supplement, his clinical symptoms progressed, prompting admission to our institution. Physical examination showed prominent bilateral pitting lower extremity edema up to his knees. Laboratory results showed potassium 2.9 mmol/L (normal, 3.5–5.3), Na+ 150 mmol/L (normal, 137–147), Ca2+ 1.89 mmol/L (normal, 2.1–2.6), alanine transaminase 145U/L, blood sugar 7.5 mmol/L, and lipase 110.8 U/L.


    Date de mise en ligne : Lundi 04 septembre 2017
    Benjamin Zucker, George Malietzis, Christos Kontovounisios
    An Unexpected Cause of Acute Abdomen
    Question: A 64-year-old, obese women with a history of schizophrenia and multiple bariatric surgeries had been attending clinics for 4 years for assessment and adjustment of her gastric band. The patient had largely been unsuccessful in losing weight and had remained oscillating around a body mass index of 46 kg/m2. In November 2016, a computed tomography scan revealed 2 hernias, which were to be repaired after further weight loss (Figure A). Two months later, the patient presented to accident and emergency with vomiting and severe abdominal pain.


    Date de mise en ligne : Vendredi 01 septembre 2017
    Marijn J. Warners, Ingrid Terreehorst, René M. van den Wijngaard, Jaap Akkerdaas, Betty C.A.M. van Esch, Ronald van Ree, Serge A. Versteeg, Andreas J.P.M. Smout, Albert J. Bredenoord
    Abnormal Responses to Local Esophageal Food Allergen Injections in Adult Patients with Eosinophilic Esophagitis
    Skin tests and measurement of serum levels of immunoglobulin E do not accurately identify foods for elimination from the diets of patients with eosinophilic esophagitis (EoE). We investigated whether an esophageal prick test (EPT), in which the esophageal mucosa is challenged by local injection of allergen extracts, could identify individuals with esophageal sensitization. During endoscopy 6 allergens were injected in the esophagus of 8 patients with EoE and 3 patients without EoE (controls). A second endoscopy was performed after 24 hrs to evaluate delayed responses.


    Date de mise en ligne : Vendredi 01 septembre 2017
    Qian Zhao, Shengwang Zhang, Aisheng Dong
    An Unusual Case of Abdominal Pain


    Date de mise en ligne : Vendredi 01 septembre 2017
    Tian-Zhi Lim, Kishore Rajaguru, Chin-Li Lee
    The Perils of Competitive Speed Eating!


    Date de mise en ligne : Vendredi 01 septembre 2017
    Yang-Yuan Chen, Cheng-Che Chen
    Natural Course of Unusual Primary Liver Tumor


    Date de mise en ligne : Vendredi 01 septembre 2017
    Everson L.A. Artifon, Hugo G. Guedes, Spencer Cheng
    How to Maximize the Diagnostic Yield of Endoscopic Ultrasound-Guided Fine Needle Aspiration Biopsy
    The first endoscopic ultrasound-guided fine needle aspiration biopsy (EUS-FNA) was performed in 1991 for the diagnosis of mucinous cystadenoma of the pancreas.1 Since then, endoscopic ultrasound imaging has advanced with regard to the diagnosis of pancreatic lesions, as well as other organs, providing the possibility of collecting materials for cytologic and/or anatomopathologic analysis with low risk of adverse events,2,3 with an estimated sensitivity of 85%–93%.4 However, the diagnostic yield of EUS-FNA continues to be a challenge and is influenced by variables such as lesion characteristics, endosonographer experience, needle properties, ability to puncture the lesion, technique and number of punctures, immediate cytologic evaluation, sample preparation, and pathologist interpretation.


    Date de mise en ligne : Vendredi 01 septembre 2017
    Andrew T. Chan, Christopher S. Williams
    Covering the Cover
    In a large cohort of patients with chronic hepatitis C infection, sustained virologic response after direct-acting antiviral therapy lowered, but did not eliminate, the risk of hepatocellular carcinoma.


    Date de mise en ligne : Vendredi 01 septembre 2017
    Florian Rieder
    ROCKing the Field of Intestinal Fibrosis or Between a ROCK and a Hard Place?
    Intestinal fibrosis remains one of the largest clinical challenges in the field of inflammatory bowel diseases.1 More than one-half of the patients with Crohn’s disease develop clinically apparent fibrostenosis throughout their disease course, leading to hospitalizations, and the need for endoscopic interventions or surgery.1 Observational studies have taught us that despite the emergence of biologics, including anti-tumor necrosis factor antibodies, the rate of surgical interventions has only mildly decreased.


    Date de mise en ligne : Vendredi 01 septembre 2017
    Peter R. Gibson, Rebecca Burgell
    Easing Concerns About the Low FODMAP Diet in Patients With Irritable Bowel Syndrome
    Dietary management makes sense in patients with irritable bowel syndrome, because food is a major inducer of symptoms, and dietary manipulation empowers patients to influence the outcome of their disorder. It is not surprising, therefore, that the arrival of the low FODMAP diet, which is based on sound scientific evidence,1 has led to its enthusiastic adoption in clinical practice across the world. However, the diet has been criticized in 4 main areas: (1) the strength of the efficacy data, mainly owing to perceived bias in clinical trial design and the lack of real-world placebo-controlled trials2,3; (2) the complexity and difficulty of teaching the diet; (3) safety, especially on the structure of gut microbiota4; and (4) longer term efficacy and safety.


    Date de mise en ligne : Vendredi 01 septembre 2017
    Mohamed Rela, Mettu Srinivas Reddy
    Pediatric Liver Transplantation: An Asymmetrical War for Access to Livers
    The United States has lead the way in developing organ-sharing algorithms with emphasis on reducing waiting-list mortality.1 Allocation based on the Model for End-stage Liver Disease score has been a revolutionary measure, not just for upholding the principle of ‘sickest first’ before ‘best use,’ but also for successfully applying it across a vast nation. In this issue of Gastroenterology, Hsu et al2 report their analysis of liver offers to the pediatric liver transplantation waiting list over a 5-year period.


    Date de mise en ligne : Vendredi 01 septembre 2017
    V. Raman Muthusamy
    Enhanced Reprocessing of Duodenoscopes: Is Doing More Better?
    Although the potential for infections to be transmitted between patients due to inadequately reprocessed duodenoscopes was initially identified >30 years ago,1 several recent fatal outbreaks of carbapenem-resistant Enterobacteriaceae associated with duodenoscope-transmission have brought this issue worldwide attention.2-4 To date, up to 350 patients at 41 facilities may have acquired infections from contaminated duodenoscopes since 2010.5 Unlike previous instances of endoscope-related transmission of infections, no significant breaches in manufacturer-recommended reprocessing protocols were identified at the affected sites when reviewed by the Centers for Disease Control and Prevention and the device manufacturers.


    Date de mise en ligne : Vendredi 01 septembre 2017
    Raoel Maan, Jordan J. Feld
    Risk for Hepatocellular Carcinoma After Hepatitis C Virus Antiviral Therapy With Direct-acting Antivirals: Case Closed?
    The development of direct-acting antivirals (DAAs) for the treatment of hepatitis C virus (HCV) infection was well-received by patients and physicians, as viral clearance is associated with improved liver-related and overall survivals.1,2 Despite this remarkable advance, it is expected that HCV-induced cirrhosis and its complications will continue to increase for many years.3,4 In fact, modeling studies predict that by 2030 almost one-half of those with HCV in the United States will have cirrhosis.


    Date de mise en ligne : Vendredi 01 septembre 2017
    Emma Clerx, Sonia S. Kupfer, Daniel A. Leffler
    Disparities in National Institutes of Health Funding Between Gastrointestinal Disorders
    The National Institutes of Health (NIH) is the major funder of research in gastrointestinal (GI) diseases. The National Institute for Diabetes and Digestive and Kidney Diseases’ discretionary appropriation for fiscal 2016 is $1.818 billion of the overall NIH $32.31 billion.1 As such, NIH support is essential for improving our understanding of health and disease from pathologic mechanisms to clinical trials. In theory, outside of specific request for funding applications the NIH distributes grants based on “meritorious science” as judged by peer reviewers, rather than favoring specific diseases.


    Date de mise en ligne : Vendredi 01 septembre 2017
    Haeseong Park, Boasheng Chen, Matthew A. Ciorba
    Progress in PD-1–based Immunotherapy: New Mechanistic Insight May Provide Expanded Hope for Application to Colon and Gastrointestinal Cancers
    Kamphorst AO, Wieland A, Tahseen Nasti T, et al. Rescue of exhausted CD8 T cells by PD-1–targeted therapies is CD28-dependent. Science 2017;355:1423-1427.


    Date de mise en ligne : Vendredi 01 septembre 2017
    Reena Khanna, Guangyong Zou
    Is a Biosimilar Interchangeable With an Originator?
    What's in a name? That which we call a rose by any other name would smell as sweet.William Shakespeare, Romeo and Juliet (Act 2, Scene 2, Page 2)


    Date de mise en ligne : Vendredi 01 septembre 2017
    Raymond K. Cross
    Anti-Tumor Necrosis Factor Therapy in Inflammatory Bowel Disease
    Anti-Tumor Necrosis Factor Therapy in Inflammatory Bowel Disease is a comprehensive review of the use of anti-tumor necrosis factor (TNF) therapy in patients with inflammatory bowel disease (IBD). The book includes a preface and 35 chapters, which can be broken down into 5 major sections. The first section highlights the science behind anti-TNF therapy, including the physiologic role of TNF in mucosal immunology, the pathophysiologic role of TNF in IBD, and the mechanism of action of anti-TNF therapy.


    Date de mise en ligne : Vendredi 01 septembre 2017
    Sebastian Zundler, Anika Klingberg, Daniela Schillinger, Sarah Fischer, Clemens Neufert, Imke Atreya, Matthias Gunzer, Markus F. Neurath
    3D Cross-Sectional Imaging of the Inflamed Gut With Light Sheet Fluorescence Microscopy for Translational Research in IBD
    The precise pathogenesis of inflammatory bowel diseases (IBD) such as Crohn’s disease (CD) or ulcerative colitis (UC) is still unclear. However, novel treatment options have become available recently1,2 and several further compounds might soon help to further improve IBD therapy.3 Importantly, development of these drugs would not have been possible without translational research including preclinical studies in murine models. In such studies, imaging of diseased tissue is essential to characterize potential targets.


    Date de mise en ligne : Mercredi 30 août 2017
    John Ong, Carla Swift, Yasseen Al-Naeeb
    Dysphagia: Multiple Pathologies, One Cause


    Date de mise en ligne : Mercredi 30 août 2017
    Takaaki Yoshikawa, Masaya Ohana, Akihisa Fukuda
    An Unusual Cause of Halitosis


    Date de mise en ligne : Mercredi 30 août 2017
    Li Liu, Reiko Nishihara, Zhi Rong Qian, Fred K. Tabung, Daniel Nevo, Xuehong Zhang, Mingyang Song, Yin Cao, Kosuke Mima, Yohei Masugi, Yan Shi, Annacarolina da Silva, Tyler Twombly, Mancang Gu, Wanwan Li, Tsuyoshi Hamada, Keisuke Kosumi, Kentaro Inamura, Jonathan A. Nowak, David A. Drew, Paul Lochhead, Katsuhiko Nosho, Kana Wu, Molin Wang, Wendy S. Garrett, Andrew T. Chan, Charles S. Fuchs, Edward L. Giovannucci, Shuji Ogino
    Association Between Inflammatory Diet Pattern and Risk of Colorectal Carcinoma Subtypes Classified by Immune Responses to Tumor
    Dietary patterns affect systemic and local intestinal inflammation, which have been linked to colorectal carcinogenesis. Chronic inflammation can interfere with the adaptive immune response. We investigated whether the association of a diet that promotes intestinal inflammation with risk of colorectal carcinoma was stronger for tumors with lower lymphocytic reactions than tumors with higher lymphocytic reactions.


    Date de mise en ligne : Mercredi 30 août 2017
    Ambre Riba, Maïwenn Olier, Sonia Lacroix-Lamandé, Corinne Lencina, Valérie Bacquié, Cherryl Harkat, Marion Gillet, Marine Baron, Caroline Sommer, Virginie Mallet, Christel Salvador-Cartier, Fabrice Laurent, Vassilia Théodorou, Sandrine Ménard
    Paneth Cell Defects Induce Microbiota Dysbiosis In Mice And Promote Visceral Hypersensitivity
    Separation of newborn rats from their mothers induces visceral hypersensitivity and impaired epithelial secretory cell lineages when they are adults. Little is known about the mechanisms by which maternal separation causes visceral hypersensitivity or its relationship with defects in epithelial secretory cell lineages.


    Date de mise en ligne : Mercredi 30 août 2017
    Barbara Bielawska, Lawrence C. Hookey, Rinku Sutradhar, Marlo Whitehead, Jianfeng Xu, Lawrence F. Paszat, Linda Rabeneck, Jill Tinmouth
    Anesthesia Assistance in Outpatient Colonoscopy and Risk of Aspiration Pneumonia, Bowel Perforation, and Splenic Injury
    The increase in use of anesthesia assistance (AA) to achieve deep sedation with propofol during colonoscopy has significantly increased colonoscopy costs without evidence for increased quality and with possible harm. We investigated the effects of AA on colonoscopy complications, specifically bowel perforation, aspiration pneumonia, and splenic injury.


    Date de mise en ligne : Mercredi 30 août 2017
    N. Jewel Samadder, John F. Valentine, Kajsa Affolter
    A Rare Cause of Diarrhea and Polyposis


    Date de mise en ligne : Mercredi 30 août 2017
    James F. Crismale, Stephen C. Ward, Jawad Ahmad
    An Unusual Cause of Abdominal Pain and Biliary Obstruction in a Patient with Hepatocellular Carcinoma


    Date de mise en ligne : Mercredi 30 août 2017
    Bader A. Alajlan, C. Prakash Gyawali
    Dysphagia following neck surgery


    Date de mise en ligne : Lundi 28 août 2017
    KyeongJin Kim, Dongryeol Ryu, Paola Dongiovanni, Lale Ozcan, Shruti Nayak, Beatrix Ueberheide, Luca Valenti, Johan Auwerx, Utpal B. Pajvani
    Degradation of PHLPP2 by KCTD17, via a Glucagon-dependent Pathway, Promotes Hepatic Steatosis
    Obesity-induced non-alcoholic fatty liver disease (NAFLD) develops, in part, via excess insulin-stimulated hepatic de novo lipogenesis, which increases, paradoxically, in patients with obesity-induced insulin resistance. Pleckstrin homology domain leucine-rich repeat protein phosphatase 2 (PHLPP2) terminates insulin signaling by dephosphorylating Akt; levels of PHLPP2 are reduced in livers from obese mice. We investigated whether loss of hepatic PHLPP2 is sufficient to induce fatty liver in mice, mechanisms of PHLPP2 degradation in fatty liver, and expression of genes that regulate PHLPP2 in livers of patients with NAFLD.


    Date de mise en ligne : Lundi 28 août 2017
    Sinju Sundaresan, Cameron A. Meininger, Anthony J. Kang, Amanda L. Photenhauer, Michael M. Hayes, Nirakar Sahoo, Jolanta Grembecka, Tomasz Cierpicki, Lin Ding, Thomas J. Giordano, Tobias Else, David J. Madrigal, Malcolm J. Low, Fiona Campbell, Ann-Marie Baker, Haoxing Xu, Nicholas A. Wright, Juanita L. Merchant
    Gastrin Induces Nuclear Export and Proteasome Degradation of Menin in Enteric Glial Cells
    The multiple endocrine neoplasia, type 1 (MEN1) locus encodes the nuclear protein and tumor suppressor menin. MEN1 mutations frequently cause neuroendocrine tumors (NETs) such as gastrinomas, characterized by their predominant duodenal location and local metastasis at time of diagnosis. Diffuse gastrin cell hyperplasia precedes the appearance of MEN1 gastrinomas, which develop within submucosal Brunner’s glands. We investigated how menin regulates expression of the gastrin gene and induces generation of submucosal gastrin-expressing cell hyperplasia.


    Date de mise en ligne : Samedi 26 août 2017
    Mathilde Dusséaux, Guillemette Masse-Ranson, Sylvie Darche, James Ahodantin, Yan Li, Oriane Fiquet, Elodie Beaumont, Pierrick Moreau, Lise Rivière, Christine Neuveut, Patrick Soussan, Philippe Roingeard, Dina Kremsdorf, James P. Di Santo, Helene Strick-Marchand
    Viral load affects the immune response to HBV in mice with humanized immune system and liver
    Chronic HBV infections, and the resulting cross talk between the immune system and infected hepatocytes, are modeled in novel humanized mice.


    Date de mise en ligne : Vendredi 25 août 2017
    Yuji Toiyama, Yoshinaga Okugawa, Koji Tanaka, Toshimitsu Araki, Keiichi Uchida, Asahi Hishida, Motoi Uchino, Hiroki Ikeuchi, Seiichi Hirota, Masato Kusunoki, C. Richard Boland, Ajay Goel
    A Panel of Methylated MicroRNA Biomarkers for Identifying High-Risk Patients with Ulcerative Colitis-associated Colorectal Cancer
    Methylation of specific microRNAs (miRNAs) often occurs in an age-dependent manner, as a field defect in some instances, and may be an early event in colitis-associated carcinogenesis. We aimed to determine whether specific mRNA signature patterns (MIR1, MIR9, MIR124, MIR137, MIR34B/C) could be used to identify patients with ulcerative colitis (UC) patients who are at increased risk for colorectal neoplasia.


    Date de mise en ligne : Vendredi 25 août 2017
    Aurelia Lugea, Andreas Gerloff, Hsin-Yuan Su, Zhihong Xu, Ariel Go, Cheng Hu, Samuel W. French, Jeremy S. Wilson, Minoti V. Apte, Richard T. Waldron, Stephen J. Pandol
    Combination of Alcohol and Cigarette Smoke Induces Endoplasmic Reticulum Stress and Cell Death in Pancreatic Acinar Cells
    Smoking, an independent risk factor for pancreatitis, accelerates the development of alcoholic pancreatitis. Alcohol feeding of mice induces upregulation of spliced X-box binding protein 1 (XBP1s), which regulates the endoplasmic reticulum (ER) unfolded protein response and promotes cell survival upon ER stress. We examined whether smoking affects the adaptive mechanisms induced by alcohol and accelerates disorders of the ER in pancreatic acinar cells.


    Date de mise en ligne : Vendredi 25 août 2017
    Brian G. Feagan, Bruce E. Sands, Guillermo Rossiter, Xiaobin Li, Keith Usiskin, Xiaojiang Zhan, Jean-Frédéric Colombel
    Effects of Mongersen (GED-0301) on Endoscopic and Clinical Outcomes in Patients With Active Crohn’s Disease
    GED-0301 is an antisense oligodeoxynucleotide with a sequence complementary to the Smad7 mRNA transcript. Smad7 is a negative regulator of transforming growth factor-β, which is increased in the intestinal mucosa of patients with active Crohn’s disease (CD). We randomly assigned 63 CD patients to 4-, 8-, or 12-week treatment groups receiving oral GED-0301 (160 mg/day). The primary objective was to determine GED-0301’s effect on endoscopic CD measures; secondary objectives included effects on clinical activity.


    Date de mise en ligne : Jeudi 24 août 2017
    Jia-Huei Tsai, Peter S. Rabinovitch, Danning Huang, Thomas Small, Aras N. Mattis, Sanjay Kakar, Won-Tak Choi
    Association of Aneuploidy and Flat Dysplasia With Development of High-Grade Dysplasia or Colorectal Cancer in Patients With Inflammatory Bowel Disease
    There is controversy over how to best manage patients with inflammatory bowel disease (IBD) and flat low-grade dysplasia (fLGD) in the colon. We performed a retrospective analysis of formalin-fixed paraffin-embedded colon tissues with fLGD from 37 patients undergoing surveillance colonoscopy for IBD, from 1990 to 2015 at the University of California at San Francisco Medical Center, to determine whether detection of aneuploidy is associated with later development of high-grade dysplasia (HGD) or colorectal cancer (CRC).


    Date de mise en ligne : Jeudi 24 août 2017
    Megan A. Adams, Katherine M. Prenovost, Jason A. Dominitz, Robert G. Holleman, Eve A. Kerr, Sarah L. Krein, Sameer D. Saini, Joel H. Rubenstein
    Predictors of Use of Monitored Anesthesia Care for Outpatient Gastrointestinal Endoscopy in a Capitated Payment System
    Use of monitored anesthesia care (MAC) for gastrointestinal endoscopy has increased in the Veterans Health Administration (VHA), as in fee-for-service environments, despite the absence of financial incentives. We investigated factors associated with use of MAC in an integrated healthcare delivery system with a capitated payment model.


    Date de mise en ligne : Mercredi 23 août 2017
    Bradley Anderson, Aruna Rangan, Seth Sweetser
    A Large Retroperitoneal Mass in an Asymptomatic 22-year-old Man


    Date de mise en ligne : Mercredi 23 août 2017
    Giuseppe Corrias, Serena Monti, Lorenzo Mannelli
    Right Upper Quadrant pain in a 47-years-old female


    Date de mise en ligne : Samedi 19 août 2017
    Susanna Nikolaus, Berenice Schulte, Natalie Al-Massad, Florian Thieme, Dominik M. Schulte, Johannes Bethge, Ateequr Rehman, Florian Tran, Konrad Aden, Robert Häsler, Natalie Moll, Gregor Schütze, Markus J. Schwarz, Georg H. Waetzig, Philip Rosenstiel, Michael Krawczak, Silke Szymczak, Stefan Schreiber
    Increased Tryptophan Metabolism is Associated With Activity of Inflammatory Bowel Diseases
    Administration of tryptophan, and some of its metabolites, reduces the severity of colitis in mice, whereas removing tryptophan from the diet increases susceptibility to colitis. Transfer of the intestinal microbiome can increase susceptibility of mice to colitis. We aimed to systematically evaluate serum levels of tryptophan and its metabolites in patients with inflammatory bowel diseases (IBD), and study their association with clinical and serologic features.


    Date de mise en ligne : Vendredi 18 août 2017
    Correction
    Bureau C, Thabut D, Oberti F, et al. Transjugular intrahepatic portosystemic shunts with covered stents increase transplant-free survival of patients with cirrhosis and recurrent ascites. Gastroenterology 2017;152:157–163.


    Date de mise en ligne : Jeudi 17 août 2017
    Anoop Kumar, Ishita Chatterjee, Tarunmeet Gujral, Anas Alakkam, Hayley Coffing, Arivarasu N. Anbazhagan, Alip Borthakur, Seema Saksena, Ravinder K. Gill, Waddah A. Alrefai, Pradeep K. Dudeja
    Activation of NF-κB by Tumor Necrosis Factor in Intestinal Epithelial Cells and Mouse Intestinal Epithelia Reduces Expression of the Chloride Transporter SLC26A3
    Diarrhea associated with inflammatory bowel diseases (IBD) has been associated with increased levels of inflammatory cytokines, including tumor necrosis factor (TNF). The intestinal mucosa of patients with IBD has reduced expression of solute carrier family 26 member 3 (SLC26A3, also called DRA). We investigated whether TNF directly affects expression of DRA in human intestinal epithelial cells (IECs) and in intestines of mice, and studied the mechanisms of these effects.


    Date de mise en ligne : Jeudi 17 août 2017
    Christian C. Abnet, Melina Arnold, Wen-Qiang Wei
    Epidemiology of Esophageal Squamous Cell Carcinoma
    Esophageal squamous cell carcinoma (ESCC) accounts for about 90% of the 456,000 incident esophageal cancers each year. Regions of high incidence include Eastern to Central Asia, along the Rift Valley in East Africa, and into South Africa. There are many causes of ESCC, which vary among regions. Early studies in France associated smoking cigarettes and heavy alcohol consumption with high rates of ESCC, but these factors can’t explain the high incidence in other regions. We discuss other risk factors for ESCC, including polycyclic aromatic hydrocarbons from a variety of sources, high-temperature foods, diet, and oral health and the microbiome—all require further research.


    Date de mise en ligne : Jeudi 17 août 2017
    Sunny H. Wong, Liuyang Zhao, Xiang Zhang, Geicho Nakatsu, Juqiang Han, Weiqi Xu, Xue Xiao, Thomas NY. Kwong, Ho Tsoi, William KK. Wu, Zeng Benhua, Francis KL. Chan, Joseph JY. Sung, Hong Wei, Jun Yu
    Gavage of Fecal Samples From Patients with Colorectal Cancer Promotes Intestinal Carcinogenesis in Germ-free and Conventional Mice
    Altered gut microbiota is implicated in development of colorectal cancer (CRC). Some intestinal bacteria have been reported to potentiate intestinal carcinogenesis by producing genotoxins, altering the immune response and intestinal micro-environment, and activating oncogenic signaling pathways. We investigated whether stool from patients with CRC could directly induce colorectal carcinogenesis in mice.


    Date de mise en ligne : Jeudi 17 août 2017
    Kaori Ikegami, Yasuo Hirose, Osamu Yoneyama
    An unusual cause of severe epigastric pain


    Date de mise en ligne : Jeudi 17 août 2017
    Shuji Yamamoto, Minoru Yamada, Kazuyoshi Matsumura
    Mimicking small intestinal anisakiasis


    Date de mise en ligne : Mardi 15 août 2017
    Anna Lok, Carol A. Burke, Sheila E. Crowe, Karen L. Woods
    Society Leadership and Diversity: Hail to the Women!
    A landmark event occurred in Chicago at Digestive Disease Week (DDW) in May 2017. For the first time in history, all four gastroenterology and hepatology societies in the United States have women presidents: the American Association for the Study of Liver Diseases (AASLD), the American College of Gastroenterology (ACG), the American Gastroenterological Association (AGA), and the American Society for Gastrointestinal Endoscopy (ASGE). This occurrence was not the result of careful coordination, but a timing coincidence and a significant signal that the GI societies recognize the importance of diversity and inclusion for all our members.


    Date de mise en ligne : Vendredi 11 août 2017
    Angad S. Uberoi, Brian D. Badgwell, Manoop S. Bhutani
    An unusual gastric antral mass


    Date de mise en ligne : Vendredi 11 août 2017
    Ruhail Kohli, Hubert H. Fenton, Lisa Forman
    Unusual cause of elevated liver enzymes in a female patient


    Date de mise en ligne : Vendredi 11 août 2017
    Hassan Ashktorab, Sonia S. Kupfer, Hassan Brim, John M. Carethers
    Racial Disparity in Gastrointestinal Cancer Risk
    Cancer from the gastrointestinal tract and its associated excretory organs will occur in more than 300,000 Americans in 2017, with colorectal cancer responsible for >40% of that burden; there will be more than 150,000 deaths from this group of cancers in the same time period. Disparities among subgroups related to the incidence and mortality of these cancers exist. The epidemiology and risk factors associated with each cancer bear out differences for racial groups in the United States. Esophageal adenocarcinoma is more frequent in non-Hispanic whites, whereas esophageal squamous cell carcinoma with risk factors of tobacco and alcohol is more frequent among blacks.


    Date de mise en ligne : Vendredi 11 août 2017
    Linda S. Yang, Damian Dowling
    A rare complication of infliximab


    Date de mise en ligne : Jeudi 10 août 2017
    Antoine Debourdeau, Anne Bozon, Romain Altwegg
    "An uncommon cause of feverish swelling in a patient with Crohn’s disease"


    Date de mise en ligne : Jeudi 10 août 2017
    Yang-Yuan Chen, Shu-Xiang Wang, Cheng-Che Chen
    An Unusual Cause of Upper Gastrointestinal Bleeding


    Date de mise en ligne : Jeudi 10 août 2017
    Anh D. Nguyen, Abrar Ahmed, Rajeev Jain
    A Peculiar Cause of Rectal Prolapse


    Date de mise en ligne : Jeudi 10 août 2017
    Abhijeet Yadav, Joseph D. Feuerstein
    A refractory disease with recurrent profuse watery diarrhea


    Date de mise en ligne : Mercredi 09 août 2017
    Chofit Chai, Mila Rivkin, Liav Berkovits, Alina Simerzin, Elina Zorde-Khvalevsky, Nofar Rosenberg, Shiri Klein, Dayana Yaish, Ronen Durst, Shoshana Shpitzen, Shiran Udi, Joseph Tam, Joerg Heeren, Anna Worthmann, Christoph Schramm, Johannes Kluwe, Revital Ravid, Eran Hornstein, Hilla Giladi, Eithan Galun
    Metabolic Circuit Involving Free Fatty Acids, microRNA 122, and Triglyceride Synthesis in Liver and Muscle Tissues
    Effective treatments are needed for hepatic steatosis characterized by accumulation of triglycerides in hepatocytes, which leads to hepatocellular carcinoma. MicroRNA 122 (MIR122) is expressed only in the liver, where it regulates lipid metabolism. We investigated the mechanism by which free fatty acids (FFAs) regulate MIR122 expression and the effect of MIR122 on triglyceride synthesis.


    Date de mise en ligne : Mercredi 09 août 2017
    Lisa B. VanWagner, Hongyan Ning, Norrina B. Allen, Veeral Ajmera, Cora E. Lewis, John Jeffrey Carr, Donald M. Lloyd-Jones, Norah A. Terrault, Juned Siddique
    Alcohol Use and Cardiovascular Disease Risk in Patients with Nonalcoholic Fatty Liver Disease
    Cardiovascular disease (CVD) is the leading cause of death among patients with non-alcoholic fatty liver disease (NAFLD). Moderate drinking (vs abstinence) is associated with lower risk of CVD in the general population. We assessed whether alcohol use is associated with CVD risk in patients with NAFLD.


    Date de mise en ligne : Mercredi 09 août 2017
    Charlotte D'Mello, Wagdi Almishri, Hongqun Liu, Mark Gordon Swain
    Interactions Between Platelets and Inflammatory Monocytes Affect Sickness Behavior in Mice With Liver Inflammation
    Patients with inflammatory liver disease commonly develop debilitating symptoms, called sickness behaviors, which arise via changes in brain function. Monocytes that produce tumor necrosis factor (TNF) interact with cerebral endothelial cells to activate microglial cells and promote sickness behavior. Platelets regulate inflammation, and aggregates of monocytes and platelets are increased in the circulation of patients with liver disease. We investigated the role of platelets in inducing inflammatory features of circulating monocytes and promoting sickness behaviors in mice with cholestatic liver injury.


    Date de mise en ligne : Mercredi 09 août 2017
    Matthew T. Moyer, Setareh Sharzehi, Abraham Mathew, John M. Levenick, Brandy D. Headlee, Jonathan T. Blandford, Heather D. Heisey, James H. Birkholz, Brooke B. Ancrile, Jennifer L. Maranki, Niraj J. Gusani, Thomas J. McGarrity, Charles E. Dye
    The Safety and Efficacy of an Alcohol-free Pancreatic Cyst Ablation Protocol
    Endoscopic ultrasound (EUS)-guided chemoablation with ethanol lavage followed by infusion of paclitaxel, is effective for the treatment of mucinous pancreatic cysts. However, complications arise in 3%–10% of patients, presumably linked to the inflammatory effects of ethanol. We aimed to determine whether alcohol is required for effective pancreatic cyst ablation, if removing alcohol from the ablation process would improve complication rates, and whether a multi-agent chemotherapeutic cocktail could increase the rate of complete cyst resolution compared to the findings reported from previous trials using alcohol followed by paclitaxel alone.


    Date de mise en ligne : Lundi 07 août 2017
    Paul C. Adams
    The Irony of Long-term Acid Suppression
    The effect of acid suppression on decreasing non-heme intestinal iron absorption has been known for decades.1 The clinical implications of this effect in the population, however, has not been great because human intestinal iron absorption is dominated by heme iron absorption which may not be affected by changes in intestinal pH. Previous studies have suggested that the use of proton pump inhibitors could inhibit iron absorption in hemochromatosis patients and could be an adjunct to other therapies such as therapeutic phlebotomy.


    Date de mise en ligne : Vendredi 04 août 2017
    C. Prakash Gyawali, Ronnie Fass
    Management of Gastroesophageal Reflux Disease
    Management of GERD commonly starts with an empiric trial of proton pump inhibitor (PPI) therapy and complementary lifestyle measures, for patients without alarm symptoms. Optimization of therapy (improving compliance and timing of PPI doses), or increasing PPI dosage to twice daily in select circumstances, can reduce persistent symptoms. Patients with continued symptoms can be evaluated with endoscopy and tests of esophageal physiology, to better determine their disease phenotype and optimize treatment.


    Date de mise en ligne : Vendredi 04 août 2017
    Federica Ungaro, Carlotta Tacconi, Luca Massimino, Paola Antonia Corsetto, Carmen Correale, Philippe Fonteyne, Andrea Piontini, Valeria Garzarelli, Francesca Calcaterra, Silvia Della Bella, Antonino Spinelli, Michele Carvello, Angela Maria Rizzo, Stefania Vetrano, Luciana Petti, Gionata Fiorino, Federica Furfaro, Domenico Mavilio, Krishna Rao Maddipati, Alberto Malesci, Laurent Peyrin-Biroulet, Silvia D’Alessio, Silvio Danese
    MFSD2A Promotes Endothelial Generation of Inflammation-resolving Lipid Mediators and Reduces Colitis in Mice
    Alterations in signaling pathways that regulate resolution of inflammation (resolving pathways) contribute to pathogenesis of ulcerative colitis (UC). The resolution process is regulated by lipid mediators, such as those derived from the ω-3 docosahexaenoic acid (DHA), whose esterified form is transported by the major facilitator superfamily domain containing 2A (MFSD2A) through the endothelium of brain, retina, and placenta. We investigated if and how MFSD2A regulates lipid metabolism of gut endothelial cells to promote resolution of intestinal inflammation.


    Date de mise en ligne : Vendredi 04 août 2017
    Exam 5: American Gastroenterological Association Institute Technical Review on the Role of Therapeutic Drug Monitoring in the Management of Inflammatory Bowel Diseases


    Date de mise en ligne : Vendredi 04 août 2017
    Exam 4: American Gastroenterological Association Institute Guideline on Therapeutic Drug Monitoring in Inflammatory Bowel Disease


    Date de mise en ligne : Vendredi 04 août 2017
    Exam 3: Practice Patterns for Cholecystectomy After Endoscopic Retrograde Cholangiopancreatography for Patients With Choledocholithiasis


    Date de mise en ligne : Vendredi 04 août 2017
    Exam 2: Risk Stratification for Covert Invasive Cancer Among Patients Referred for Colonic Endoscopic Mucosal Resection: A Large Multicenter Cohort


    Date de mise en ligne : Vendredi 04 août 2017
    Exam 1: Detection, Diagnosis, and Resection of Sessile Serrated Adenomas and Polyps


    Date de mise en ligne : Vendredi 04 août 2017
    Dennis M. Jensen
    Reply
    Thank you, Dr Gin-Ho Lo, for your comments about our randomized controlled trial (RCT) of Doppler endoscopic probe (DEP) as a guide to improving risk stratification and definitive endoscopic hemostasis of severe nonvariceal upper gastrointestinal hemorrhage (NVUGIH). I offer the following response to help readers put the RCT into perspective. For gastrointestinal clinician-endoscopists, DEP can increase efficacy and reduce workload by improving definitive hemostasis of severe NVUGIH. Our hypothesis, now proven by our prior cohort study and the RCT results, is that arterial blood flow underneath stigmata of recent hemorrhage (SRH) is what determines risks of rebleeding both before and after endoscopic treatment.


    Date de mise en ligne : Vendredi 04 août 2017
    Edward Gane
    Reply
    We thank Dr Yu and colleagues for their letter. We agree that the presence of baseline NS5A resistance-associated substitutions in patients with hepatitis C virus genotype 2 infection reduces the efficacy of ultrashort durations of ledipasvir-sofosbuvir. This is particularly pertinent for patients infected with subtype 2a, where the “wild type” virus seems to harbor NS5A resistance-associated substitutions (10/11 treatment-naïve patients had either K30R and/or L31M at baseline).


    Date de mise en ligne : Vendredi 04 août 2017
    Hugo E. Vargas

    The difficult task of linking histology findings with the clinical picture daunts many beginning clinicians, and can be a source of frustration for seasoned practitioners as well. Resorting to review of detailed pathology textbooks, clinicopathologic conference notes, and electronic references has limited use because many times these supplements lack the focus needed to facilitate decision making and communication.


    Date de mise en ligne : Vendredi 04 août 2017
    Ming-Lung Yu
    Resistance-Associated Substitutions in Short Duration of Interferon-Free Direct-Acting Antivirals for Hepatitis C
    We read with great interest the report of Gane et al.1 They evaluated the efficacy and safety of direct-acting antivirals, ledipasvir-sofosbuvir fixed dose combination, for chronic hepatitis C virus genotype 2 infection. The rate of sustained virologic response 12 weeks after the end of treatment was 96% (25/26) in the first cohort of hepatitis C virus genotype 2 patients receiving 12 weeks of treatment, but only 74% (20/27) in the second cohort with an 8-week regimen.


    Date de mise en ligne : Vendredi 04 août 2017
    Daniel Schmidt-Martin, Matthew J. Armstrong, Ian A. Rowe
    Transplant-Free Survival Rates After Covered Transjugular Intrahepatic Portosystemic Shunt
    We acknowledge the challenges identified by the authors in the management of recurrent or refractory ascites.1 Although data identifying candidate suitability for transjugular intrahepatic portosystemic shunt (TIPSS) is satisfactory, the optimum timing of TIPSS remains challenging. This randomized, controlled trial proposes to establish whether such patients might be best managed using large volume paracentesis with supplementary albumin (LVP+A) or TIPSS using a covered stent. Although the reported transplant-free survival rates at the 1-year follow-up seem to be compelling at 52% and 93%, respectively, we feel that aspects of the manuscript raise important questions with regard to patient selection, reasons for the rates of treatment failure, and patient outcomes.


    Date de mise en ligne : Vendredi 04 août 2017
    Gin-Ho Lo
    Does the Use of Doppler Endoscopic Probe in Hemostasis of Nonvariceal Gastrointestinal Bleeding Increase Efficacy or Work Load?
    I read with interest the article by Jensen et al1 regarding the use of a Doppler endoscopic probe (DEP) in hemostasis of nonvariceal gastrointestinal bleeding. The authors demonstrated that use of a DEP can significantly reduce the rebleeding rate of nonvariceal upper gastrointestinal bleeding from 26.3% in the control group to 11.1% in the DEP group. Although innovative and interesting, a few points need further clarification.


    Date de mise en ligne : Vendredi 04 août 2017
    Werner Keenswijk, Katrien Van Renterghem, Johan Vande Walle
    A Case Report of a Child With Purpura, Severe Abdominal Pain, and Hematochezia
    Question: A 5-year old Caucasian boy presented with sudden onset of diffuse purpuric and petechial skin lesions without fever at the pediatric department. The following days he developed diffuse abdominal pain with bloody stools (4-6 times a day). He also complained of scrotal pain and joint pain (knee, ankles). His previous medical history was unrevealing. Family history was negative for autoimmune or gastrointestinal diseases. He had not taken medication besides paracetamol. Clinical examination revealed an alert but tachycardic boy with a blood pressure of 130/90 mm Hg.


    Date de mise en ligne : Vendredi 04 août 2017
    Thomas Malikowski, Allison L. Yang, Thomas J. Beckman
    Altered Bowel Habits and Occult Gastrointestinal Bleeding in a 67-Year-Old Man
    Question: A 67-year-old man with a history of chronic lymphocytic leukemia (CLL) complicated by recurrent bacterial infections presented to the outpatient clinic with an abrupt onset of altered bowel habits. He reported the urge to defecate several times per day, but only had occasional passage of small, semisolid stools. At baseline, he typically experienced having 1 to 2 large bowel movements per day. Screening colonoscopy was performed 3 years prior and was notable for a 4-mm tubular adenoma in the ascending colon, with an adequate bowel preparation noted.


    Date de mise en ligne : Vendredi 04 août 2017
    Chuncheng Wu, Qiongying Zhang, Bing Hu
    A Huge Mass in the Upper Esophagus
    Question: A 56-year-old man with a history of mild dysphagia for 4 months experienced worsening of his symptoms when he caught a cold or was tired, but without nausea, vomiting, acid reflux, abdominal pain, or bloating. He had no history of diabetes mellitus, hypertension, or heart disease, and did not smoke or drink alcohol. Physical examination was unremarkable.


    Date de mise en ligne : Jeudi 03 août 2017
    Ahmed N. Hegazy, Nathaniel R. West, Michael J.T. Stubbington, Emily Wendt, Kim I.M. Suijker, Angeliki Datsi, Sebastien This, Camille Danne, Suzanne Campion, Sylvia H. Duncan, Benjamin M.J. Owens, Holm H. Uhlig, Andrew McMichael, Oxford IBD Cohort Investigators, Andreas Bergthaler, Sarah A. Teichmann, Satish Keshav, Fiona Powrie
    Circulating and Tissue-resident CD4+ T Cells With Reactivity to Intestinal Microbiota Are Abundant in Healthy Individuals and Function is Altered During Inflammation
    Interactions between commensal microbes and the immune system are tightly regulated and maintain intestinal homeostasis, but little is known about these interactions in humans. We investigated responses of human CD4+ T cells to the intestinal microbiota. We measured the abundance of T cells in circulation and intestinal tissues that respond to intestinal microbes and determined their clonal diversity. We also assessed their functional phenotypes and effects on intestinal resident cell populations, and studied alterations in microbe-reactive T cells in patients with chronic intestinal inflammation.


    Date de mise en ligne : Jeudi 03 août 2017
    Joseph D. Feuerstein, Geoffrey C. Nguyen, Sonia S. Kupfer, Yngve Falck-Ytter, Siddharth Singh, American Gastroenterological Association Institute Clinical Guidelines Committee
    American Gastroenterological Association Institute Guideline on Therapeutic Drug Monitoring in Inflammatory Bowel Disease
    This document presents the official recommendations of the American Gastroenterological Association (AGA) on therapeutic drug monitoring (TDM) in inflammatory bowel disease (IBD). The guideline was developed by the AGA’s Clinical Guidelines Committee and approved by the AGA Governing Board. It is accompanied by a Technical Review, which is a compilation of clinical evidence from which these recommendations were formulated.1


    Date de mise en ligne : Jeudi 03 août 2017
    Keith A. Sacco, Omar Y. Mousa, Ming-Hsi Wang
    Chronic Abdominal Pain and Cutaneous Swelling
    Question: A 51-year-old man was referred to our tertiary medical center for a 3-year history of intermittent abdominal pain, diarrhea, and associated nontender, nonitchy cutaneous erythema and swelling of his upper and lower extremities (Figure A) and scrotum. Each episode lasted for 5 to 8 weeks before resolution. Medical history included gastroesophageal reflux disorder (on pantoprazole 40 mg/d) and essential hypertension (on losartan 50 mg/d for the past 3 years). Previous workup included unremarkable findings in esophagogastroduodenal scope and colonoscopy examinations within past 1 year.


    Date de mise en ligne : Jeudi 03 août 2017
    Najib Nassani, Sherif Andrawes, Liliane Deeb
    What Is Afflicting This Woman With Celiac Disease?
    Question: A 75-year-old woman with celiac disease diagnosed 30 years ago who is not compliant with a gluten-free diet, and has gastroesophageal reflux disease and hypothyroidism, presented with gradually worsening abdominal distension, severe intermittent suprapubic cramping abdominal pain, nausea, vomiting, and nonbloody diarrhea of 10 days duration. Her past surgical history was notable for right inguinal herniorrhaphy. She denied fever and chills, but reported minimal weight loss. Her family history was notable for pancreatic cancer in her sister and lung cancer in her father.


    Date de mise en ligne : Jeudi 03 août 2017
    Tarek Debs, Niccolo Petrucciani, Jean Gugenheim
    Why Would a Patient Complain of Dysphagia and Heartburn After Multiple Bariatric Surgeries?
    Question: A 43-year-old woman presented for management of a complication of her bariatric surgery. The history goes back to September 2000 when the patient presented with a body mass index (BMI) of 45 (120 kg to 1.63 m). An adjustable gastric band was placed. One year postoperatively, the band migrated, which resulted in removal of the band. In 2003, the patient regained weight and reached a BMI of 47 kg/m2. She underwent a Roux-en-Y gastric bypass. The Roux-en-Y gastric bypass failed in the long term; the patient regained weight and reached a BMI of 45.


    Date de mise en ligne : Jeudi 03 août 2017
    Ana Loureiro, Marco Dioguardi Burgio, Valérie Vilgrain
    A Rare Cause of Pancreatitis
    Question: A 32-year-old woman with a past medical history relevant for active smoking and Behçet disease diagnosed 15 years before, with vascular, articular manifestations and an acute pancreatitis that was attributed to ischemia owing to Behçet vasculitis (celiac trunk dissection). She was medicated with cyclophosphamide and corticosteroids.


    Date de mise en ligne : Jeudi 03 août 2017
    Xiang-Yang Wang, Zhi-Yuan Chen, Yu-Ming Yang
    An Unusual Cause of Hematochezia
    Question: A 21-year-old man with a 3-year history of hematochezia presented to the gastroenterology department with drop bright red blood after defecation, which was aggravated after eating spicy foods. He denied any history of hepatitis. On physical examination, the patient had an anemic appearance. Laboratory tests showed severe anemia (hemoglobin, 2.8 g/dL), but normal coagulation function, serum ammonia, and liver function. Colonoscopy showed internal hemorrhoids with no other abnormalities.


    Date de mise en ligne : Jeudi 03 août 2017
    Norihiro Sakai, Kenya Kamimura, Shuji Terai
    A Huge Abdominal Tumor
    Question: An 88-year-old man was admitted to our hospital with the chief complaint of left flank pain. He had a history of ileocecal resection and sigmoidectomy for the treatment of colon cancer 7 years ago and has been treated for diabetes mellitus for >20 years. Laboratory findings showed a mild elevation of the white blood cell count (12,000/μL) and C-reactive protein (6.3 mg/dL), blood sugar (180 mg/dL), and hemoglobin A1c (8.9%) levels. No elevation of tumor marker levels was observed. Imaging studies showed an irregularly shaped, 70-mm tumor in the left side of the abdomen with an invasive growth pattern toward the abdominal wall and colon.


    Date de mise en ligne : Jeudi 03 août 2017
    Malay Sharma, Abid Showkat, Piyush Somani
    An Unusual Cause of Biliary Colic
    Question: A 30-year-old woman presented with recurrent episodes of biliary colic for last 3 months. There was no history of fever, yellowish discoloration of eyes or urine, and weight loss. Clinical examination was normal. Laboratory investigations revealed the following: total leukocyte count, 6900/L; serum bilirubin, 2.0 mg/dL (normal, 0.2–1.0); aspartate aminotransferase, 87 U/L (normal, 5–50); alanine aminotransferase, 95 U/L (normal, 0–50); serum alkaline phosphatase, 220 U/L (normal, 25–125); serum amylase, 24 U (normal, 20–80); and serum lipase, 32 U/L (normal, 0–190).


    Date de mise en ligne : Mercredi 02 août 2017
    Helen G. Coleman, Shao-Hua Xie, Jesper Lagergren
    The Epidemiology of Esophageal Adenocarcinoma
    The incidence of esophageal adenocarcinoma (EAC) has increased in many Western countries, and is higher in men than women. Some risk factors for EAC have been identified—mainly gastroesophageal reflux disease (GERD), Barrett’s esophagus, obesity, and tobacco smoking. It is not clear whether interventions to address these factors can reduce risk of EAC, although some evidence exists for smoking cessation. Although consumption of alcohol is not associated with EAC risk, other exposures, such as physical activity, nutrition, and medication use, require further study.


    Date de mise en ligne : Mercredi 02 août 2017
    Joel E. Richter, Joel H. Rubenstein
    Presentation and Epidemiology of Gastroesophageal Reflux Disease
    Gastroesophageal reflux disease (GERD) is the most prevalent gastrointestinal disorder in the United States, and leads to substantial morbidity, though associated mortality is rare. The prevalence of GERD symptoms appeared to increase until 1999. Risk factors for complications of GERD include advanced age, male sex, white race, abdominal obesity, and tobacco use. Most patients with GERD presents with heartburn and effortless regurgitation. Coexistent dysphagia is considered an alarm symptom, prompting evaluation.


    Date de mise en ligne : Mercredi 02 août 2017
    Xicheng Liu, Wendi Wei, Xiaowei Li, Pengcheng Shen, Dapeng Ju, Zhen Wang, Rukui Zhang, Fu Yang, Chunyan Chen, Kun Cao, Guoli Zhu, Hongyan Chen, Liang Chen, Jianhua Sui, Erquan Zhang, Kaichun Wu, Fengchao Wang, Liping Zhao, Rongwen Xi
    BMI1 and MEL18 Promote Colitis-Associated Cancer in Mice via REG3B and STAT3
    This study documents that BMI1 and MEL18 are required for colitis-associated cancer (CAC) development via regulating a novel REG3B-STAT3 signaling pathway. The findings may have wide implications for the prevention and treatment of CAC.


    Date de mise en ligne : Mercredi 02 août 2017
    Fabian J. Bolte, Ashley C. O’Keefe, Lauren M. Webb, Elisavet Serti, Elenita Rivera, T. Jake Liang, Marc Ghany, Barbara Rehermann
    Intra-hepatic Depletion of Mucosal Associated Invariant T cells in Hepatitis C Virus-induced Liver Inflammation
    Chronic hepatitis affects phenotypes of innate and adaptive immune cells. Mucosal associated invariant T (MAIT) cells are enriched in the liver as compared to the blood, respond to intra-hepatic cytokines, and (via the semi-invariant T-cell receptor) to bacteria translocated from the gut. Little is known about the role of MAIT cells in livers of patients with chronic hepatitis C virus (HCV) infection and their fate after antiviral therapy.


    Date de mise en ligne : Mercredi 02 août 2017
    Yanjie Zhao, Lixuan Wei, Mingming Shao, Xudong Huang, Jiang Chang, Jian Zheng, Jiahui Chu, Qionghua Cui, Linna Peng, Yingying Luo, Wenle Tan, Wen Tan, Dongxin Lin, Chen Wu
    BRCA1 Associated Protein Increases Invasiveness of Esophageal Squamous-Cell Carcinoma
    We performed a screen for genes whose expression correlates with invasiveness of esophageal squamous-cell carcinoma (ESCC) cells. We studied the effects of overexpression and knockdown of these genes in cell lines and expression levels in patient samples.


    Date de mise en ligne : Mardi 01 août 2017
    Massimiliano di Pietro, Marcia I. Canto, Rebecca C. Fitzgerald
    Endoscopic Management of Early Adenocarcinoma and Squamous Cell Carcinoma of the Esophagus—Screening, Diagnosis, and Therapy
    Since the esophagus is easily accessible with endoscopy, early diagnosis and curative treatment of esophageal cancer is possible. However, diagnosis is often delayed because symptoms are not specific during early stages of tumor development. The onset of dysphagia is associated with advanced disease, and fewer than 15% of patients survive for 5 years. Population screening by endoscopy is not cost effective, but a number of alternative imaging and cell analysis technologies are under investigation.


    Date de mise en ligne : Mardi 01 août 2017
    American Gastroenterological Association
    Therapeutic Drug Monitoring in Inflammatory Bowel Disease


    Date de mise en ligne : Lundi 31 juillet 2017
    Michael F. Vaezi, Daniel Sifrim
    Assessing Old and New Diagnostic Tests for Gastroesophageal Reflux Disease
    A detailed critique of objective measurements of gastroesophageal reflux disease (GERD) would improve management of patients suspecting of having reflux, leading to rational selection of treatment and better outcomes. Many diagnostic tests for GERD have been developed over the past decades. We analyze their development, positive- and negative-predictive values, and ability to predict response to treatment. These features are important for development of medical, surgical, and endoscopic therapies for GERD.


    Date de mise en ligne : Lundi 31 juillet 2017
    Evan S. Dellon, Ikuo Hirano
    Epidemiology and Natural History of Eosinophilic Esophagitis
    Eosinophilic esophagitis (EoE) has emerged over the past 2 decades as a major cause of upper gastrointestinal morbidity. Over this time, the epidemiology of EoE has also rapidly evolved. EoE has transformed from a rare case-reportable condition to disease that is commonly encountered in the gastroenterology clinic, hospital emergency room, and endoscopy suite. The incidence and prevalence are increasing at rates that outpace increased disease recognition. Current incidence estimates range from 5 to 10 cases per 100,000, and current prevalence estimates range from 0.5 to 1 case per 1000.


    Date de mise en ligne : Lundi 31 juillet 2017
    Andrew T. Chan, Christopher S. Williams
    Covering the Cover
    In a cohort of obese Latino and African American children, 9 days of isocaloric restriction decreased liver fat, visceral fat, and de novo lipogenesis, and improved insulin kinetics.


    Date de mise en ligne : Lundi 31 juillet 2017
    American Gastroenterological Association
    Therapeutic Drug Monitoring in Inflammatory Bowel Disease: A Patient Guide
    Clinical practice guidelines are developed under the guidance of the American Gastroenterological Association (AGA) Institute Clinical Guideline Committee and provide evidence-based recommendations for clinical practice in the field of gastroenterology. The clinical practice guidelines and related Clinical Decision Support Tools support evidence-based clinical decision making by gastroenterologists and other health-care professionals at the point of care. The information that follows presents important content from those guidelines in a way that will help patients better understand AGA’s recommendations for evaluating, diagnosing, or managing a condition.


    Date de mise en ligne : Lundi 31 juillet 2017
    Niels Vande Casteele, Hans Herfarth, Jeffry Katz, Yngve Falck-Ytter, Siddharth Singh
    American Gastroenterological Association Institute Technical Review on the Role of Therapeutic Drug Monitoring in the Management of Inflammatory Bowel Diseases
    Therapeutic drug monitoring (TDM), which involves measurement of drug or active metabolite levels and anti-drug antibodies, is a promising strategy that can be used to optimize inflammatory bowel disease therapeutics. It is based on the premise that there is a relationship between drug exposure and outcomes, and that considerable inter-individual variability exists in how patients metabolize the drug (pharmacokinetics) and the magnitude and duration of response to therapy (pharmacodynamics). Therefore, the American Gastroenterological Association has prioritized clinical guidelines on the role of TDM in the management of inflammatory bowel disease.


    Date de mise en ligne : Samedi 29 juillet 2017
    Yangchun Xie, Shan Zhu, Meizuo Zhong, Minghua Yang, Xiaofan Sun, Jinbao Liu, Guido Kroemer, Michael Lotze, Herbert J. Zeh, Rui Kang, Daolin Tang
    Inhibition of Aurora Kinase A Induces Necroptosis in Pancreatic Carcinoma
    Induction of non-apoptotic cell death could be an approach to eliminate apoptosis-resistant tumors. We investigated necroptosis-based therapies in mouse models of pancreatic ductal adenocarcinoma cancer (PDAC).


    Date de mise en ligne : Vendredi 28 juillet 2017
    Michael Camilleri, Richard W. McCallum, Jan Tack, Sharon C. Spence, Keith Gottesdiener, Fred T. Fiedorek
    Efficacy and Safety of Relamorelin in Diabetics with Symptoms of Gastroparesis:A Randomized, Placebo-Controlled Study
    Gastroparesis is a complication of diabetes with few treatment options. Relamorelin (also called RM-131) is a selective, prokinetic agonist of ghrelin. We aimed to evaluate efficacy of relamorelin on symptoms and gastric emptying (GE) in a 12-week, phase 2B study of diabetic patients with moderate to severe gastroparesis symptoms (DG).


    Date de mise en ligne : Vendredi 28 juillet 2017
    Esmée J. Grobbee, Eline H. Schreuders, Bettina E. Hansen, Marco J. Bruno, Iris Lansdorp-Vogelaar, Manon C.W. Spaander, Ernst J. Kuipers
    Association Between Concentrations of Hemoglobin Determined by Fecal Immunochemical Tests and Long-term Development of Advanced Colorectal Neoplasia
    Colorectal cancer (CRC) screening using quantitative fecal immunochemical tests (FITs) is rapidly gaining ground worldwide. FITs are invariably used in a dichotomous manner using pre-specified cut-off values. To optimize FIT-based screening programs, we investigated the association between fecal hemoglobin (fHb) concentrations below the FIT cut-off value and later development of colorectal advanced neoplasia.


    Date de mise en ligne : Vendredi 28 juillet 2017
    Heiko Pohl
    Carving Out a Place for Endoscopic Submucosal Dissection
    The larger the polyp, the greater the cancer risk. Among polyps >20 mm in size, the risk may exceed 10%.1 Although some polyps portray overt signs of cancer through their pit pattern or a depressed morphology,2,3 others are covert without such worrisome characteristics. Cancers with minimal invasion into the submucosa can be removed completely by endoscopic resection and, in the absence of lymphovascular invasion or poor differentiation, for almost all complete resection equates to cure.4 To prove a healthy margin and confirm complete resection, the polyp has to be removed in 1 piece (en bloc).


    Date de mise en ligne : Vendredi 28 juillet 2017
    Miriam B. Vos, Michael I. Goran
    Sugar, Sugar . . . Not So Sweet for the Liver
    In this issue of Gastroenterology, Schwarz et al1 report on the “Impact of Dietary Fructose Restriction on Liver Fat, De Novo Lipogenesis and Insulin Kinetics in Children with Obesity.” There are 3 recent developments important to the context and impact of the study. First, nonalcoholic fatty liver disease (NAFLD) is highly prevalent in children and the prevalence seems to be increasing.2 NAFLD in children occurs in a setting of excess weight gain and insulin resistance, and it foretells ongoing metabolic decline including type 2 diabetes3 and future cardiovascular disease.


    Date de mise en ligne : Vendredi 28 juillet 2017
    David J. Bjorkman
    Proton Pump Inhibitors and Chronic Kidney Disease: Causation or Another False Alarm?
    In this issue of Gastroenterology Klatte et al1 report an association of chronic kidney disease with proton pump inhibitor (PPI) use. This paper adds to the large number of observational studies suggesting an association of PPIs with different conditions. Many of these reports have attracted attention in the lay and professional press.2,3 Gastroenterologists are increasingly asked about the safety of long-term PPI therapy. Although the possibility of PPIs increasing the risk of adverse outcomes has resulted appropriately in scrutiny of patients taking PPIs for questionable indications or at doses higher than necessary, it has also produced exaggerated concerns by patients and physicians about appropriate PPI use.


    Date de mise en ligne : Vendredi 28 juillet 2017
    Lieven Pouillon, Peter Bossuyt, Laurent Peyrin-Biroulet
    Tofacitinib Is the Right OCTAVE for Ulcerative Colitis
    Sandborn W, Su C, Sands BE, et al. Tofacitinib as Induction and Maintenance Therapy for Ulcerative Colitis. N Engl J Med 2017;376:2017;1723-1736.


    Date de mise en ligne : Vendredi 28 juillet 2017
    Suraj V. Suresh, Shail M. Govani, Akbar K. Waljee
    Chromoendoscopy versus White Light Endoscopy: Does it Matter?
    Ten Hove JR, et al. Clinical implications of low grade dysplasia found during inflammatory bowel disease surveillance: a retrospective study comparing chromoendoscopy and white-light endoscopy. Endoscopy 2017;49:161-168.


    Date de mise en ligne : Vendredi 28 juillet 2017
    Poonam Mishra, Jeffry Florian, Joy Peter, Monika Vainorius, Michael W. Fried, David R. Nelson, Debra Birnkrant
    Public–Private Partnership: Targeting Real-World Data for Hepatitis C Direct-Acting Antivirals
    The era of direct-acting antivirals (DAAs) has transformed the treatment landscape for chronic hepatitis C virus (HCV) infection. Primarily this is due to the approval of multiple DAAs that are highly efficacious with improved safety profiles that became available within a short time span.1 Regulatory agencies have a public health responsibility to ensure the safety and efficacy of approved drug products. Although the demonstrated safety and efficacy of the drugs in registrational trials is paramount, the continued safety and effectiveness of drugs and treatment outcomes in diverse clinical care settings after a drug’s approval are of great importance.


    Date de mise en ligne : Vendredi 28 juillet 2017
    Yuval A. Patel, Joanne C. Imperial, Andrew J. Muir, Quentin M. Anstee, David DeBrota, Lara Dimick-Santos, Claudia Filozof, Ruby Mehta, Arun J. Sanyal, Elmer Schabel, Brent A. Neuschwander-Tetri, Veronica Miller, Liver Forum’s Data Standardization Working Group
    Baseline Parameters in Clinical Trials for Nonalcoholic Steatohepatitis: Recommendations From the Liver Forum
    Nonalcoholic fatty liver disease (NAFLD) is the most prevalent form of chronic liver disease in the world, affecting an estimated 25% of the global adult population.1 Liver-related morbidity and mortality attributed to NAFLD are substantial, and fibrosis seems to be the strongest independent predictor of outcome.2 Fibrosis develops among patients with the nonalcoholic steatohepatitis (NASH) phenotype, making it the biologically relevant focus of drug development.3 Currently, there are no approved therapies to treat NASH, although many drugs are in development.


    Date de mise en ligne : Vendredi 28 juillet 2017
    Christen Klochan Dilly, Justin L. Sewell
    How to Give Feedback During Endoscopy Training
    Training fellows to perform endoscopy is challenging. Most trainers genuinely desire to be good teachers, but competing demands can be difficult to navigate. As we consider the hypothetical example below, think about what you might do differently.


    Date de mise en ligne : Vendredi 28 juillet 2017
    De-Chen Lin, Ming-Rong Wang, H. Phillip Koeffler
    Genomic and Epigenomic Aberrations in Esophageal Squamous Cell Carcinoma and Implications for Patients
    Esophageal squamous cell carcinoma (ESCC) is a common malignancy without effective therapy. The exomes of more than 600 ESCCs have been sequenced in the last 4 years, and numerous key aberrations have been identified1-4. Recently, researchers reported both inter- and intra-tumor heterogeneity5, 6. Although these are interesting observations, their clinical implications are unclear due to limited number of samples profiled. Epigenomic alterations, such as changes in DNA methylation, histone acetylation, and RNA editing, have also been observed in ESCCs.


    Date de mise en ligne : Vendredi 28 juillet 2017
    Kelly M. O’Shea, Seema S. Aceves, Evan S. Dellon, Sandeep K. Gupta, Jonathan M. Spergel, Glenn T. Furuta, Marc E. Rothenberg
    Pathophysiology of Eosinophilic Esophagitis
    Eosinophilic esophagitis (EoE) is an emerging disease that is distinguished from gastroesophageal reflux disease (GERD) by the expression of a unique esophageal transcriptome and the interplay of early life environmental factors with distinct genetic susceptibility elements at 5q22 (TSLP) and 2p23 (CAPN14). Rare genetic syndromes have uncovered the contribution of barrier disruption, mediated in part by defective desmosomes and dysregulated transforming factor beta (TGF-β) production and signaling, to EoE pathophysiology.


    Date de mise en ligne : Mercredi 26 juillet 2017
    Alex Straumann, David A. Katzka
    Diagnosis and Treatment of Eosinophilic Esophagitis
    Eosinophilic esophagitis (EoE) is a new disease. It is caused by a T-helper 2 cell response to food antigens in contact with the esophageal mucosa. Although no single feature defines EoE, a constellation of compatible demographic, clinical, endoscopic, and histologic findings establish the diagnosis. Children present with symptoms and endoscopic patterns characteristic of inflammation whereas adolescents and adults have manifestations of fibrosis and gross esophageal strictures. Clinical and endoscopic scoring systems have helped to standardize diagnosis.


    Date de mise en ligne : Mercredi 26 juillet 2017
    Felicia M. Bloemendaal, Alon D. Levin, Manon E. Wildenberg, Pim J. Koelink, Bradford L. McRae, Jochen Salfeld, Jenifer Lum, Marijn van der Neut Kolfschoten, Jill W. Claassens, Remco Visser, Arthur Bentlage, Geert R.A.M. D’Haens, J. Sjef Verbeek, Gestur Vidarsson, Gijs R. van den Brink
    Anti-Tumor Necrosis Factor with a Glyco-engineered Fc Region Has Increased Efficacy in Mice with Colitis
    Although tumor necrosis factor (TNF) antagonists reduce many clinical features of inflammatory bowel disease (IBD), complete mucosal healing occurs in less than 50% of patients. The Fc region of monoclonal antibodies against TNF has immunosuppressive properties via effects on macrophage polarization. We examined the interaction between the anti-TNF Fc region and Fcγ receptors (FcγR), and whether the absence of the Fc core fucose (which increases binding to FcγRIIIa) increases the efficacy of anti-TNF in mice with colitis.


    Date de mise en ligne : Vendredi 21 juillet 2017
    Ilaria Pergolini, Klaus Sahora, Cristina R. Ferrone, Vicente Morales-Oyarvide, Brian M. Wolpin, Lorelei A. Mucci, William R. Brugge, Mari Mino-Kenudson, Manuel Patino, Dushyant V. Sahani, Andrew L. Warshaw, Keith D. Lillemoe, Carlos Fernández-del Castillo
    Long-Term Risk of Pancreatic Malignancy in Patients with Branch Duct Intraductal Papillary Mucinous Neoplasm in A Referral Center
    Little is known about development of branch duct intraductal papillary mucinous neoplasms (BD-IPMNs). We evaluated long-term outcomes of a large cohort of patients with BD-IPMNs to determine risk of malignancy and define a subset of low-risk BD-IPMNs.


    Date de mise en ligne : Jeudi 20 juillet 2017
    Alexander Larson, Ferga Gleeson, Elizabeth Rajan
    25-Year-Old female with a deceptive pancreas cyst: all is not as it appears!


    Date de mise en ligne : Mercredi 19 juillet 2017
    P. Woodland, J.L. Ooi, F. Grassi, K. Nikaki, C. Lee, J.A. Evans, N. Koukias, C. Triantos, S.A. McDonald, M. Peiris, R. Aktar, L.A. Blackshaw, D. Sifrim
    Superficial esophageal mucosal afferent nerves may contribute to reflux hypersensitivity in non-erosive reflux disease
    Little is known about the causes of heartburn in patients with gastro-esophageal reflux disease (GERD). Visible epithelial damage is seldom associated with symptom severity, evidenced by the significant symptom burden in patients with non-erosive reflux disease (NERD) compared to patients with erosive reflux disease (ERD) or Barrett’s esophagus (BE). We studied the distribution of mucosal nerve fibers in patients with NERD, ERD, and BE, and compared the results with those of healthy subjects.


    Date de mise en ligne : Mercredi 19 juillet 2017
    Sabela Lens, Edilmar Alvarado, Zoe Mariño, María-Carlota Londoño, Elba LLop, Javier Martinez, Jose Ignacio Fortea, Luís Ibañez, Xavier Ariza, Anna Baiges, Adolfo Gallego, Rafael Bañares, Angela Puente, Agustín Albillos, Jose Luís Calleja, Xavier Torras, Virginia Hernández-Gea, Jaume Bosch, Cándid Villanueva, Xavier Forns, Juan Carlos García-Pagán
    Effects of All-oral Anti-viral Therapy on HVPG and Systemic Hemodynamics in Patients with Hepatitis C Virus-associated Cirrhosis
    Patients with hepatitis C virus (HCV)-associated cirrhosis and clinical significant portal hypertension (CSPH, hepatic venous pressure gradient [HVPG] 10 mmHg or greater), despite achieving sustained virological response (SVR) to therapy, remain at risk of liver decompensation. We investigated hemodynamic changes following SVR in patients with CSPH and whether liver stiffness measurements (LSMs) can rule out the presence of CSPH.


    Date de mise en ligne : Mercredi 19 juillet 2017
    Shivan J. Mehta, Jordyn Feingold, Matthew Vandertuyn, Tess Niewood, Catherine Cox, Chyke A. Doubeni, Kevin G. Volpp, David A. Asch
    Active Choice and Financial Incentives to Increase Rates of Screening Colonoscopy—a Randomized Controlled Trial
    Behavioral economic approaches could increase uptake for colorectal cancer screening. We performed a randomized controlled trial of 2245 employees to determine whether an email containing a phone number for scheduling (control), an email with the active choice to opt in or opt out (active choice), or the active choice email plus a $100 incentive (financial incentive) increased colonoscopy completion within 3 months. Higher proportions of participants in the financial incentive group underwent screening (3.7%) than in the control (1.6%) or active choice groups (1.5%) (P=.01 and P <.01).


    Date de mise en ligne : Mercredi 19 juillet 2017
    Hyuk Moon, Hye-Lim Ju, Sook In Chung, Kyung Joo Cho, Jung Woo Eun, Suk Woo Nam, Kwang-Hyub Han, Diego F. Calvisi, Simon Weonsang Ro
    Transforming Growth Factor Beta Promotes Liver Tumorigenesis in Mice via Upregulation of Snail
    Transforming growth factor beta (TGFB) suppresses early stages of tumorigenesis, but also contributes to migration and metastasis of cancer cells. A large number of human tumors contain mutations that inactivate its receptors, or downstream proteins such as Smad transcription factors, indicating that the TGFB signaling pathway prevents tumor growth. We investigated the effects of TGFB inhibition on liver tumorigenesis in mice.


    Date de mise en ligne : Mardi 18 juillet 2017
    Ming-Hung Hsu, Yi-Ju Chen, Wen-Lun Wang
    An unusual colon cystic tumor


    Date de mise en ligne : Mardi 18 juillet 2017
    Sreelakshmi Kotha, Ioannis Koumoutsos
    A case of mistaken identity


    Date de mise en ligne : Mardi 18 juillet 2017
    Yuichiro Rikitake, Shuhei Fukunaga, Hirohiko Abe
    Case of a young man with abdominal pain and jaundice


    Date de mise en ligne : Mardi 18 juillet 2017
    Juliette Gueguen, Guillaume Hanouna, Jonathan M. Chemouny
    Persistent hypokalemia with renal losses in a 31-year-old pregnant woman


    Date de mise en ligne : Mardi 18 juillet 2017
    Arjun R. Sondhi, Marc Piper, Matthew J. DiMagno
    Stack of coins sign in a patient with recurrent abdominal pain


    Date de mise en ligne : Mardi 18 juillet 2017
    Gaurav Ghosh, Nicole Shen, Arun B. Jesudian
    Coffee Bean Sign with a Twist


    Date de mise en ligne : Mardi 18 juillet 2017
    Robert S. Robinson, Rohan M. Modi, Somashekar G. Krishna
    Acute Abdominal Pain and Hematochezia in a Long-Distance Runner


    Date de mise en ligne : Mardi 18 juillet 2017
    Paul Lochhead, Kaitlin Hagan, Amit D. Joshi, Hamed Khalili, Long H. Nguyen, Francine Grodstein, Andrew T. Chan
    Association Between Proton Pump Inhibitor Use and Cognitive Function in Women
    Studies have reported associations between proton pump inhibitor (PPI) use and dementia. However, data are lacking on long-term PPI use and cognitive function. We therefore examined associations between PPI use and performance in tests of cognitive function. Because of shared clinical indications, we examined associations for H2 receptor antagonists (H2RAs) as a secondary aim.


    Date de mise en ligne : Vendredi 14 juillet 2017
    Sander P.J. Joosten, Jurrit Zeilstra, Harmen van Andel, R. Clinton Mijnals, Joost Zaunbrecher, Annet A.M. Duivenvoorden, Marc van de Wetering, Hans Clevers, Marcel Spaargaren, Steven T. Pals
    MET Signaling Mediates Intestinal Crypt-Villus Development, Regeneration, and Adenoma Formation and Is Promoted by Stem Cell CD44 Isoforms
    Resistance of metastatic human colorectal cancer cells to drugs that block epidermal growth factor (EGF) receptor signaling could be caused by aberrant activity of other receptor tyrosine kinases, activating overlapping signaling pathways. One of these receptor tyrosine kinases could be MET, the receptor for hepatocyte growth factor (HGF). We investigated how MET signaling, and its interaction with CD44 (a putative MET coreceptor regulated by Wnt signaling and highly expressed by intestinal stem cells [ISCs] and adenomas) affects intestinal homeostasis, regeneration, and adenoma formation in mini-gut organoids and mice.


    Date de mise en ligne : Vendredi 14 juillet 2017
    Gianmarco Contino, Thomas L. Vaughan, David Whiteman, Rebecca C. Fitzgerald
    The Evolving Genomic Landscape of Barrett’s Esophagus and Esophageal Adenocarcinoma
    We have recently gained unprecedented insight into genetic factors that determine risk for Barrett’s esophagus (BE) and progression to esophageal adenocarcinoma (EA). Next-generation sequencing technologies have allowed us to identify somatic mutations that initiate BE and track genetic changes during development of tumors and invasive cancer. These technologies led to identification of mechanisms of tumorigenesis that challenge the current multistep model of progression to EA. Newer, cost-effective technologies create opportunities to rapidly translate the analysis of DNA into tools that can identify patients with BE at high risk for cancer, detect dysplastic lesions more reliably, and uncover mechanisms of carcinogenesis.


    Date de mise en ligne : Vendredi 14 juillet 2017
    Wanlu Cao, Kan Chen, Michiel Bolkestein, Yuebang Yin, Monique M.A. Verstegen, Marcel J.C. Bijvelds, Wenshi Wang, Nesrin Tuysuz, Derk ten Berge, Dave Sprengers, Herold J. Metselaar, Luc J.W. van der Laan, Jaap Kwekkeboom, Ron Smits, Maikel P. Peppelenbosch, Qiuwei Pan
    Dynamics of Proliferative and Quiescent Stem Cells in Liver Homeostasis and Injury
    Adult liver stem cells are usually maintained in a quiescent/slow-cycling state. However, a proliferative population, marked by leucine-rich repeat-containing G-protein coupled receptor 5 (LGR5), was recently identified as an important liver stem cell population. We aimed to investigate the dynamics and functions of proliferative and quiescent stem cells in healthy and injured livers.


    Date de mise en ligne : Vendredi 14 juillet 2017
    Jennifer M. Kolb, Roy M. Soetikno, Aarti K. Rao, Dean Fong, Robert V. Rouse, Tonya Kaltenbach
    Detection, Diagnosis, and Resection of Sessile Serrated Adenomas and Polyps
    Sessile serrated adenomas and polyps (SSA/Ps), especially those in the proximal colon, are recognized as precursors to colorectal cancer, yet their detection, diagnosis and resection can still pose a challenge and are not widely known.1 Herein, we summarize the current knowledge on the endoscopic approach to detect, diagnose, and treat SSA/Ps.


    Date de mise en ligne : Jeudi 13 juillet 2017
    Vincent Verdier, Minh Dung Ngo, Richard Petit
    Unusual Cause of Dysphagia


    Date de mise en ligne : Jeudi 13 juillet 2017
    Dalbir S. Sandhu, Andrew M. Bellizzi, Rami El Abiad
    Elderly lady with upper abdominal pain and 60 pounds weight loss


    Date de mise en ligne : Jeudi 13 juillet 2017
    Brian K.P. Goh, Andrew B.E. Kwek., Wei Keat Wan.
    An unusual cause of a solid-cystic pancreatic lesion


    Date de mise en ligne : Jeudi 13 juillet 2017
    Charpentier Chloé, Kottler Diane, Fite Charlotte, Anne-Laure Pelletier, Lydia Deschamps, Vincent Descamps
    A surprising granulomatous cheilitis


    Date de mise en ligne : Jeudi 13 juillet 2017
    Tao Li, Chun-Yan Hao, Zong-Li Zhang
    Hematochezia caused by a colon disease with unusual presentation


    Date de mise en ligne : Jeudi 13 juillet 2017
    Wen-Lun Wang, I-Wei Chang, Ching-Tai Lee
    An unusual rectal mass


    Date de mise en ligne : Jeudi 13 juillet 2017
    Hyun Ho Choi, Sung Soo Kim, Ok-Ran Shin
    Asymptomatic scattered pigmented flat lesions in the esophagus


    Date de mise en ligne : Jeudi 13 juillet 2017
    Johannes Hofland, Arjun D. Koch, Wouter W. de Herder
    Melaena in a patient with a metastasized neuroendocrine tumor


    Date de mise en ligne : Jeudi 13 juillet 2017
    Shenq-Jie Wong
    A Rare but Curable Cause of Iron Deficiency Anemia


    Date de mise en ligne : Jeudi 13 juillet 2017
    Obaidullah Aseem, Daniel S. Childs, Conor G. Loftus
    Diffuse small intestine erosions and ulcers in an immunocompromised host


    Date de mise en ligne : Jeudi 13 juillet 2017
    Jana G. Hashash, Aline El-Haddad, Kassem Barada
    Acute Epigastric Abdominal Pain Post-Gastric Polypectomy


    Date de mise en ligne : Jeudi 13 juillet 2017
    Angela Dolganiuc, Peter V. Draganov, Alexander Schlachterman
    Rodeo, anyone?


    Date de mise en ligne : Mercredi 12 juillet 2017
    Evelyn K. Hsu, M.L. Shaffer, L. Gao, C. Sonnenday, M.L. Volk, J. Bucuvalas, J.C. Lai
    Analysis of Liver Offers to Pediatric Candidates on the Transplant Wait List
    Approximately 10% of children on the liver transplant wait-list in the United States die every year. We examined deceased donor liver offer acceptance patterns and their contribution to pediatric wait-list mortality.


    Date de mise en ligne : Mercredi 12 juillet 2017
    Graham M. Snyder, Sharon B. Wright, Anne Smithey, Meir Mizrahi, Michelle Sheppard, Elizabeth B. Hirsch, Ram Chuttani, Riley Heroux, David S. Yassa, Lovisa B. Olafsdottir, Roger B. Davis, Anastasiou Jiannis, Vijay Bapat, Kiran Bidari, Douglas K. Pleskow, Daniel Leffler, Benjamin Lane, Alice Chen, Howard S. Gold, Anthony Bartley, Aleah D. King, Mandeep S. Sawhney
    Randomized Comparison of 3 High-level Disinfection and Sterilization Procedures for Duodenoscopes
    Duodenoscopes have been implicated in the transmission of multidrug-resistant bacteria (MDRO). We compared the frequency of duodenoscope contamination with MDRO or any other bacteria after disinfection or sterilization by 3 different methods.


    Date de mise en ligne : Mercredi 12 juillet 2017
    Olga Bednarska, Susanna A. Walter, Maite Casado-Bedmar, Magnus Ström, Eloísa Salvo-Romero, Maria Vicario, Emeran A. Mayer, Åsa V Keita
    VIP and Mast Cells Regulate Increased Passage of Colonic Bacteria in Patients With Irritable Bowel Syndrome
    Irritable bowel syndrome (IBS) is associated with intestinal dysbiosis and symptoms of IBS develop following gastroenteritis. We aimed to study the passage of live bacteria through the colonic epithelium, and determine the role of mast cells (MCs) and VIP (VIP) in barrier regulation in IBS and healthy individuals.


    Date de mise en ligne : Mercredi 12 juillet 2017
    Meenakshi Rao, Daniella Rastelli, Lauren Dong, Sophia Chiu, Wanda Setlik, Michael D. Gershon, Gabriel Corfas
    Enteric Glia Regulate Gastrointestinal Motility but Are Not Required for Maintenance of the Epithelium in Mice
    When the glial fibrillary acidic protein (GFAP) promoter is used to express cellular toxins that eliminate glia in mice, intestinal epithelial permeability and proliferation increase; this led to the concept that glia are required for maintenance of the gastrointestinal epithelium. Many enteric glia, however, particularly in the mucosa, do not express GFAP. In contrast, virtually all enteric glia express proteolipid protein 1 (PLP1). We investigated whether elimination of PLP1-expressing cells compromises epithelial maintenance or gastrointestinal motility.


    Date de mise en ligne : Mercredi 12 juillet 2017
    Ming-Whei Yu, Chih-Lin Lin, Chun-Jen Liu, Shu-Han Yang, Yu-Lin Tseng, Chih-Feng Wu
    Influence of Metabolic Risk Factors on Risk of Hepatocellular Carcinoma and Liver-related Death in Men with Chronic Hepatitis B: A Large Cohort Study
    Little is known about the absolute risk of hepatocellular carcinoma (HCC) and liver-disease related death, in association with metabolic risk factors, for patients with hepatitis B virus (HBV) infection.


    Date de mise en ligne : Vendredi 07 juillet 2017
    Fady G. Haddad, Sandy El Bitar, Liliane Deeb
    Growing in Silence!


    Date de mise en ligne : Mardi 04 juillet 2017
    Mila Hyytinen, Erkki Savilahti, Suvi M. Virtanen, Taina Härkönen, Jorma Ilonen, Kristiina Luopajärvi, Raivo Uibo, Outi Vaarala, Hans K. Åkerblom, Mikael Knip, Finnish TRIGR Pilot Study Group
    Avoidance of Cow's Milk−Based Formula for At-Risk Infants Does Not Reduce Development of Celiac Disease: A Randomized Controlled Trial
    Feeding during the first months of life might affect risk for celiac disease. Individuals with celiac disease or type 1 diabetes have been reported to have high titers of antibodies against cow’s milk proteins. Avoidance of cow’s milk−based formula for infants with genetic susceptibility for type 1 diabetes reduced the cumulative incidence of diabetes-associated autoantibodies. We performed a randomized controlled trial in the same population to study whether weaning to an extensively hydrolyzed formula reduced the risk of celiac disease autoimmunity or celiac disease.


    Date de mise en ligne : Jeudi 22 juin 2017
    Guoying Zhou, Dave Sprengers, Patrick P.C. Boor, Michail Doukas, Hannah Schutz, Shanta Mancham, Alexander Pedroza-Gonzalez, Wojciech G. Polak, Jeroen de Jonge, Marcia Gaspersz, Haidong Dong, Kris Thielemans, Qiuwei Pan, Jan N.M. IJzermans, Marco J. Bruno, Jaap Kwekkeboom
    Antibodies Against Immune Checkpoint Molecules Restore Functions of Tumor-infiltrating T cells in Hepatocellular Carcinomas
    Ligand binding to inhibitory receptors on immune cells, such as programmed cell death 1 (PD-1) and cytotoxic T-lymphocyte associated protein 4 (CTLA4), down-regulates the T-cell–mediated immune response (called immune checkpoints). Antibodies that block these receptors increase antitumor immunity in patients with melanoma, non–small-cell lung cancer, and renal cell cancer. Tumor-infiltrating CD4+ and CD8+ T cells in patients with hepatocellular carcinoma (HCC) have been found to be functionally compromised.


    Date de mise en ligne : Lundi 19 juin 2017
    Tom Holvoet, Sarah Devriese, Karolien Castermans, Sandro Boland, Dirk Leysen, Yves-Paul Vandewynckel, Lindsey Devisscher, Lien Van den Bossche, Sophie Van Welden, Melissa Dullaers, Roosmarijn E. Vandenbroucke, Riet De Rycke, Karel Geboes, Arnaud Bourin, Olivier Defert, Pieter Hindryckx, Martine De Vos, Debby Laukens
    Treatment of Intestinal Fibrosis in Experimental Inflammatory Bowel Disease by the Pleiotropic Actions of a Local Rho Kinase Inhibitor
    Intestinal fibrosis resulting in (sub)obstruction is a common complication of Crohn’s disease (CD). Rho kinases (ROCKs) play multiple roles in TGFβ-induced myofibroblast activation that could be therapeutic targets. Because systemic ROCK inhibition causes cardiovascular side effects, we evaluated the effects of a locally acting ROCK inhibitor (AMA0825) on intestinal fibrosis.


    Date de mise en ligne : Lundi 19 juin 2017
    Fasiha Kanwal, Jennifer Kramer, Steven M. Asch, Maneerat Chayanupatkul, Yumei Cao, Hashem B. El-Serag
    Risk of Hepatocellular Cancer in HCV Patients Treated With Direct Acting Antiviral Agents
    The risk of hepatocellular cancer (HCC) after sustained virological response (SVR) with direct acting antivirals (DAA) is unclear. Our aim was to examine the risk and determinants of HCC in patients cured with DAA.


    Date de mise en ligne : Samedi 17 juin 2017
    Mei Zeng, Mitchell Szymczak, Malini Ahuja, Changyu Zheng, Hongen Yin, William Swaim, John A. Chiorini, Robert J. Bridges, Shmuel Muallem
    Pharmacological Rescue of Ductal CFTR Rescue Pancreatic and Salivary Glands Acinar Cells and Tissue Function in Mouse Models of Autoimmune Diseases
    Sjögren’s syndrome and autoimmune pancreatitis are disorders with decreased function of salivary, lacrimal glands, and the exocrine pancreas. Nonobese diabetic/ShiLTJ mice and mice transduced with the cytokine BMP6 develop Sjögren’s syndrome and chronic pancreatitis and MRL/Mp mice are models of autoimmune pancreatitis. Cystic fibrosis transmembrane conductance regulator (CFTR) is a ductal Cl− channel essential for ductal fluid and HCO3− secretion. We used these models to ask the following questions: is CFTR expression altered in these diseases, does correction of CFTR correct gland function, and most notably, does correcting ductal function correct acinar function?


    Date de mise en ligne : Jeudi 15 juin 2017
    Heidi Maria Staudacher, Miranda C.E. Lomer, Freda M. Farquharson, Petra Louis, Francesca Fava, Elena Franciosi, Matthias Scholz, Kieran M. Tuohy, James O. Lindsay, Peter M. Irving, Kevin Whelan
    Diet Low in FODMAPs Reduces Symptoms in Patients With Irritable Bowel Syndrome and Probiotic Restores Bifidobacterium Species: A Randomized Controlled Trial
    Dietary restriction of fermentable carbohydrates (a low FODMAP diet) has been reported to reduce symptoms in some patients with irritable bowel syndrome (IBS). We performed a randomized, placebo-controlled study to determine its effects on symptoms and the fecal microbiota in patients with IBS.


    Date de mise en ligne : Jeudi 15 juin 2017
    Gilles Jobin, Roberto Rodriguez-Suarez, Katia Betito
    Association Between Natural Killer Cell Activity and Colorectal Cancer in High-risk Subjects Undergoing Colonoscopy
    Low activity of natural killer (NK) cells has been associated with increased risk of cancer and has been reported in patients with colorectal cancer (CRC). Activity of NK cells can be measured in a small volume of whole blood by a commercially available test. We investigated whether this test could be used to identify patients with CRC, using findings from colonoscopy as a reference standard.


    Date de mise en ligne : Jeudi 15 juin 2017
    Jing Wang, Dmitri Mouradov, Xiaojing Wang, Robert N. Jorissen, Matthew C. Chambers, Lisa J. Zimmerman, Suhas Vasaikar, Christopher G. Love, Shan Li, Kym Lowes, Karl-Johan Leuchowius, Helene Jousset, Janet Weinstock, Christopher Yau, John Mariadason, Zhiao Shi, Yuguan Ban, Xi Chen, Robert J.C. Coffey, Robbert J.C. Slebos, Antony W. Burgess, Daniel C. Liebler, Bing Zhang, Oliver M. Sieber
    Colorectal Cancer Cell Line Proteomes are Representative of Primary Tumors and Predict Drug Sensitivity
    Proteomics holds promise for individualizing cancer treatment. We analyzed to what extent the proteomic landscape of human colorectal cancer (CRC) is maintained in established CRC cell lines and the utility of proteomics for predicting therapeutic responses.


    Date de mise en ligne : Mercredi 14 juin 2017
    Daniela Sia, Yang Jiao, Iris Martinez-Quetglas, Olga Kuchuk, Carlos Villacorta-Martin, Manuel Castro de Moura, Juan Putra, Genis Camprecios, Laia Bassaganyas, Nicholas Akers, Bojan Losic, Samuel Waxman, Swan N. Thung, Vincenzo Mazzaferro, Manel Esteller, Scott L. Friedman, Myron Schwartz, Augusto Villanueva, Josep M. Llovet
    Identification of an Immune-specific Class of Hepatocellular Carcinoma, Based on Molecular Features
    Agents that induce an immune response against tumors by altering T-cell regulation have increased survival times of patients with advanced-stage tumors, such as melanoma or lung cancer. We aimed to characterize molecular features of immune cells that infiltrate hepatocellular carcinomas (HCCs) to determine whether these types of agents might be effective against liver tumors.


    Date de mise en ligne : Mercredi 14 juin 2017
    Annick Vanclooster, Cees van Deursen, Reggy Jaspers, David Cassiman, Ger Koek
    Proton Pump Inhibitors Decrease Phlebotomy Need in HFE Hemochromatosis: Double-Blind Randomized Placebo-Controlled Trial
    Phlebotomy constitutes the established treatment for HFE-related hemochromatosis. Retrospective studies have suggested proton pump inhibitors (PPIs) reduce the need for phlebotomy in this population. We conducted a randomized controlled trial to prove this. Thirty p.C282Y homozygous patients were randomly allocated to PPI (pantoprazole 40 mg/day) or placebo for 12 months. Phlebotomies were performed when serum ferritin was > 100 μg/L. Phlebotomy need turned out to be significantly lower in patients taking PPI (P = .0052).


    Date de mise en ligne : Mercredi 14 juin 2017
    Michael S. Middleton, Elhamy R. Heba, Catherine A. Hooker, Mustafa R. Bashir, Kathryn J. Fowler, Kumar Sandrasegaran, Elizabeth M. Brunt, David E. Kleiner, Edward Doo, Mark L. Van Natta, Joel E. Lavine, Brent A. Neuschwander-Tetri, Arun Sanyal, Rohit Loomba, Claude B. Sirlin, NASH Clinical Research Network
    Agreement Between Magnetic Resonance Imaging Proton Density Fat Fraction Measurements and Pathologist-Assigned Steatosis Grades of Liver Biopsies From Adults With Nonalcoholic Steatohepatitis
    We assessed the diagnostic performance of magnetic resonance imaging (MRI) proton density fat fraction (PDFF) in grading hepatic steatosis and change in hepatic steatosis in adults with nonalcoholic steatohepatitis (NASH) in a multi-center study, using central histology as reference.


    Date de mise en ligne : Mercredi 14 juin 2017
    Sara Botschuijver, Guus Roeselers, Evgeni Levin, Daisy M. Jonkers, Olaf Welting, Sigrid E.M. Heinsbroek, Heleen H. de Weerd, Teun Boekhout, Matteo Fornai, Ad A. Masclee, Frank H.J. Schuren, Wouter J. de Jonge, Jurgen Seppen, Rene M. van den Wijngaard
    Intestinal Fungal Dysbiosis Associates With Visceral Hypersensitivity in Patients With Irritable Bowel Syndrome and Rats
    Visceral hypersensitivity is one feature of irritable bowel syndrome (IBS). Bacterial dysbiosis might be involved in the activation of nociceptive sensory pathways, but there have been few studies of the role of the mycobiome (the fungal microbiome) in the development of IBS. We analyzed intestinal mycobiomes of patients with IBS and a rat model of visceral hypersensitivity.


    Date de mise en ligne : Mercredi 14 juin 2017
    Jana Nano, Mohsen Ghanbari, Wenshi Wang, Paul S. de Vries, Klodian Dhana, Taulant Muka, André G. Uitterlinden, Joyce B.J. van Meurs, Albert Hofman, BIOS consortium, Oscar H. Franco, Qiuwei Pan, Sarwa Darwish Murad, Abbas Dehghan
    Epigenome-wide Association Study Identifies Methylation Sites Associated With Liver Enzymes and Hepatic Steatosis
    Epigenetic mechanisms might be involved in the regulation of liver enzyme level. We aimed to identify CpG sites at which DNA methylation levels are associated with blood levels of liver enzymes and hepatic steatosis.


    Date de mise en ligne : Mercredi 14 juin 2017
    Katharina J. Werkstetter, Ilma R. Korponay-Szabó, Alina Popp, Vincenzo Villanacci, Marianna Salemme, Gabriele Heilig, Søren Thue Lillevang, Maria Luisa Mearin, Carmen Ribes-Koninckx, Adrian Thomas, Riccardo Troncone, Birgit Filipiak, Markku Mäki, Judit Gyimesi, Mehri Najafi, Jernej Dolinšek, Stine Dydensborg Sander, Renata Auricchio, Alexandra Papadopoulou, Andreas Vécsei, Peter Szitanyi, Ester Donat, Rafaella Nenna, Philippe Alliet, Francesca Penagini, Hélène Garnier-Lengliné, Gemma Castillejo, Kalle Kurppa, Ranaan Shamir, Almuthe Christine Hauer, Françoise Smets, Susana Corujeira, Myriam van Winckel, Stefan Buderus, Sonny Chong, Steffen Husby, Sibylle Koletzko, ProCeDE study group
    Accuracy in Diagnosis of Celiac Disease Without Biopsies in Clinical Practice
    The guidelines of the European Society of Pediatric Gastroenterology, Hepatology, and Nutrition allow for diagnosis of celiac disease without biopsies in children with symptoms and levels of immunoglobulin A against tissue-transglutaminase (TGA-IgA) 10-fold or more the upper limit of normal (ULN), confirmed by detection of endomysium antibodies (EMA) and positivity for HLA-DQ2/DQ8. We performed a large, international prospective study to validate this approach.


    Date de mise en ligne : Mercredi 07 juin 2017
    Jeff Chang, Rupert W. Leong, Valerie C. Wasinger, Matthew Ip, Michael Yang, Tri Giang Phan
    Impaired Intestinal Permeability Contributes to Ongoing Bowel Symptoms in Patients With Inflammatory Bowel Disease and Mucosal Healing
    Many patients with inflammatory bowel diseases (IBD) have ongoing bowel symptoms of diarrhea or abdominal pain despite mucosal healing. We investigated whether impaired intestinal permeability contributes to these symptoms.


    Date de mise en ligne : Lundi 05 juin 2017
    Alissa C. Nicolucci, Megan P. Hume, Inés Martínez, Shyamchand Mayengbam, Jens Walter, Raylene A. Reimer
    Prebiotics Reduce Body Fat and Alter Intestinal Microbiota in Children Who Are Overweight or With Obesity
    It might be possible to manipulate the intestinal microbiota with prebiotics or other agents to prevent or treat obesity. However, little is known about the ability of prebiotics to specifically modify gut microbiota in children with overweight/obesity or reduce body weight. We performed a randomized controlled trial to study the effects of prebiotics on body composition, markers of inflammation, bile acids in fecal samples, and composition of the intestinal microbiota in children with overweight or obesity.


    Date de mise en ligne : Vendredi 02 juin 2017
    Robert J. Huang, Monique T. Barakat, Mohit Girotra, Subhas Banerjee
    Practice Patterns for Cholecystectomy After Endoscopic Retrograde Cholangiopancreatography for Patients With Choledocholithiasis
    Cholecystectomy (CCY) after an episode of choledocholithiasis requiring endoscopic retrograde cholangiopancreatography (ERCP) with stone extraction reduces recurrent biliary events compared to expectant management. We studied practice patterns for performance of CCY after ERCP for choledocholithiasis using data from 3 large states and evaluated the effects of delaying CCY.


    Date de mise en ligne : Vendredi 02 juin 2017
    Nicholas G. Burgess, Luke F. Hourigan, Simon A Zanati, Gregor J. Brown, Rajvinder Singh, Stephen J. Williams, Spiro C. Raftopoulos, Donald Ormonde, Alan Moss, Karen Byth, Hema Mahajan, Duncan McLeod, Michael J. Bourke
    Risk Stratification for Covert Invasive Cancer Among Patients Referred for Colonic Endoscopic Mucosal Resection: A Large Multicenter Cohort
    Among patients with large colorectal sessile polyps or laterally spreading lesions, it is important to identify those at risk for submucosal invasive cancer (SMIC). Lesions with overt endoscopic evidence of SMIC are referred for surgery, although those without these features might still contain SMIC that is not visible on endoscopic inspection (covert SMIC). Lesions with a high covert SMIC risk might be better suited for endoscopic submucosal dissection than for endoscopic mucosal resection (EMR).


    Date de mise en ligne : Vendredi 02 juin 2017
    Derk C.F. Klatte, Alessandro Gasparini, Hong Xu, Pietro de Deco, Marco Trevisan, Anna L.V. Johansson, Björn Wettermark, Johan Ärnlöv, Cynthia J Janmaat, Bengt Lindholm, Friedo W. Dekker, Josef Coresh, Morgan E. Grams, Juan J. Carrero
    Association Between Proton Pump Inhibitor Use and Risk of Progression of Chronic Kidney Disease
    Proton pump inhibitors (PPI) have been associated with acute kidney injury and recent studies suggest that they may be associated with the risk of chronic kidney disease (CKD).


    Date de mise en ligne : Vendredi 02 juin 2017
    Haojie Jin, Cun Wang, Guangzhi Jin, Haoyu Ruan, Dishui Gu, Lin Wei, Hui Wang, Ning Wang, Einthavy Arunachalam, Yurong Zhang, Xuan Deng, Chen Yang, Yi Xiong, Hugang Feng, Ming Yao, Jingyuan Fang, Jianren Gu, Wenming Cong, Wenxin Qin
    Regulator of Calcineurin 1 Gene Isoform 4, Down-regulated in Hepatocellular Carcinoma, Prevents Proliferation, Migration, and Invasive Activity of Cancer Cells and Metastasis of Orthotopic Tumors by Inhibiting Nuclear Translocation of NFAT1
    Individuals with Down syndrome have a low risk for many solid tumors, prompting the search for tumor suppressor genes on human chromosome 21 (HSA21). We aimed to identify and explore potential mechanisms of tumor suppressors on HSA21 in hepatocellular carcinoma (HCC).


    Date de mise en ligne : Jeudi 01 juin 2017
    Cary C. Cotton, W. Asher Wolf, Bergein F. Overholt, Nan Li, Charles J. Lightdale, Herbert C. Wolfsen, Sarina Pasricha, Kenneth K. Wang, Nicholas J. Shaheen, AIM Dysplasia Trial Group
    Late Recurrence of Barrett’s Esophagus After Complete Eradication of Intestinal Metaplasia is Rare: Final Report From Ablation in Intestinal Metaplasia Containing Dysplasia Trial
    The goal of treatment for Barrett’s esophagus (BE) with dysplasia is complete eradication of intestinal metaplasia (CEIM). The long-term durability of CEIM has not been well characterized, so the frequency and duration of surveillance are unclear. We report results from a 5-year follow-up analysis of patients with BE and dysplasia treated by radiofrequency ablation (RFA) in the randomized controlled Ablation of Intestinal Metaplasia Containing Dysplasia (AIM) trial.


    Date de mise en ligne : Jeudi 01 juin 2017
    Jean-Marc Schwarz, Susan M. Noworolski, Ayca Erkin-Cakmak, Natalie J. Korn, Michael J. Wen, Viva W. Tai, Grace M. Jones, Sergiu P. Palii, Moises Velasco-Alin, Karen Pan, Bruce W. Patterson, Alejandro Gugliucci, Robert H. Lustig, Kathleen Mulligan
    Effects of Dietary Fructose Restriction on Liver Fat, De Novo Lipogenesis, and Insulin Kinetics in Children With Obesity
    Consumption of sugar is associated with obesity, type 2 diabetes mellitus, nonalcoholic fatty liver disease, and cardiovascular disease. The conversion of fructose to fat in liver (de novo lipogenesis [DNL]) may be a modifiable pathogenetic pathway. We determined the effect of 9 days of isocaloric fructose restriction on DNL, liver fat, visceral fat (VAT), subcutaneous fat, and insulin kinetics in obese Latino and African American children with habitual high sugar consumption (fructose intake >50 g/d).


    Date de mise en ligne : Jeudi 01 juin 2017
    Rafael Oliveira Ximenes, Juliana Prelle Vieira Costa, Karen Thalyne Pereira e Silva
    Cullen's sign - not always acute pancreatitis


    Date de mise en ligne : Jeudi 25 mai 2017
    Alicia S. Wellman, Mallikarjuna R. Metukuri, Nevzat Kazgan, Xiaojiang Xu, Qing Xu, Natalie S.X. Ren, Agnieszka Czopik, Michael T. Shanahan, Ashley Kang, Willa Chen, M. Andrea Azcarate-Peril, Ajay S. Gulati, David C. Fargo, Leonard Guarente, Xiaoling Li
    Intestinal Epithelial Sirtuin 1 Regulates Intestinal Inflammation During Aging in Mice by Altering the Intestinal Microbiota
    Intestinal epithelial homeostasis is maintained by complex interactions among epithelial cells, commensal gut microorganisms, and immune cells. Disruption of this homeostasis is associated with disorders such as inflammatory bowel disease (IBD), but the mechanisms of this process are not clear. We investigated how Sirtuin 1 (SIRT1), a conserved mammalian NAD+-dependent protein deacetylase, senses environmental stress to alter intestinal integrity.


    Date de mise en ligne : Jeudi 25 mai 2017
    Lotte Bruens, Saskia I.J. Ellenbroek, Jacco van Rheenen, Hugo J. Snippert
    In Vivo Imaging Reveals Existence of Crypt Fission and Fusion in Adult Mouse Intestine
    The intestinal epithelium is a repetitive sheet of crypt and villus units with stem cells at the bottom of the crypts. During postnatal development, crypts multiply via fission, generating 2 daughter crypts from 1 parental crypt. In the adult intestine, crypt fission is observed at a low frequency. Using intravital microscopy in Lgr5EGFP-Ires-CreERT2 mice, we monitored individual crypt dynamics over multiple days with single-cell resolution. We discovered the existence of crypt fusion, an almost exact reverse phenomenon of crypt fission, in which 2 crypts fuse into 1 daughter crypt.


    Date de mise en ligne : Lundi 22 mai 2017
    Jocelyn A. Silvester, Satya Kurada, Andrea Szwajcer, Ciarán P. Kelly, Daniel A. Leffler, Donald R. Duerksen
    Tests for Serum Transglutaminase and Endomysial Antibodies Do Not Detect Most Patients With Celiac Disease and Persistent Villous Atrophy on Gluten-free Diets: a Meta-analysis
    Tests to measure serum endomysial antibodies (EMA) and antibodies to tissue transglutaminase (tTG) were developed to screen for celiac disease in patients consuming gluten. However, they are commonly used to monitor patients on a gluten-free diet (GFD). We conducted a meta-analysis to assess the sensitivity and specificity of tTG IgA and EMA IgA assays in identifying patients with celiac disease who have persistent villous atrophy despite a GFD.


    Date de mise en ligne : Samedi 20 mai 2017
    Melinda Ráki, Shiva Dahal-Koirala, Hao Yu, Ilma R. Korponay-Szabó, Judit Gyimesi, Gemma Castillejo, Jørgen Jahnsen, Shuo-Wang Qiao, Ludvig M. Sollid
    Similar Responses of Intestinal T Cells From Untreated Children and Adults With Celiac Disease to Deamidated Gluten Epitopes
    Celiac disease is a chronic small intestinal inflammatory disorder mediated by an immune response to gluten peptides in genetically susceptible individuals. Celiac disease is often diagnosed in early childhood, but some patients receive a diagnosis late in life. It is uncertain whether pediatric celiac disease is distinct from adult celiac disease. It has been proposed that gluten-reactive T cells in children recognize deamidated and native gluten epitopes, whereas T cells from adults only recognize deamidated gluten peptides.


    Date de mise en ligne : Jeudi 04 mai 2017
    Hiang Keat Tan, Wei Qiang Leow, Pik Eu Chang
    Ruxolitinib for the Treatment of Portal Hypertension in a Patient With Primary Myelofibrosis
    Primary myelofibrosis is a form of myeloproliferative neoplasm characterized by stem-cell derived clonal proliferation, resulting in bone marrow fibrosis, splenomegaly and extramedullary haematopoiesis, with portal hypertension (PHT) occuring in 10%–20% of patients. Here, we report a patient with primary myelofibrosis whose PHT improved significantly following treatment with ruxolitinib, thereby allowing discontinuation of all drug therapy for PHT.


    Date de mise en ligne : Vendredi 24 février 2017
    Zhang-Hui Chen, Yan P. Yu, Junyan Tao, Silvia Liu, George Tseng, Michael Nalesnik, Ronald Hamilton, Rohit Bhargava, Joel B. Nelson, Arjun Pennathur, Satdarshan P. Monga, James D. Luketich, George K. Michalopoulos, Jian-Hua Luo
    MAN2A1–FER Fusion Gene Is Expressed by Human Liver and Other Tumor Types and Has Oncogenic Activity in Mice
    Human tumors and liver cancer cell lines express the product of a fusion between the first 13 exons in the mannosidase α class 2A member 1 gene (MAN2A1) and the last 6 exons in the FER tyrosine kinase gene (FER), called MAN2A1−FER. We investigated whether MAN2A1−FER is expressed by human liver tumors and its role in liver carcinogenesis.


    Date de mise en ligne : Mercredi 04 février 2015
    David T. Rubin
    The Rationale and Growth of Advanced Training in Inflammatory Bowel Disease


    Date de mise en ligne : Lundi 17 novembre 2014
    Steven F. Moss
    The Great Ulcer War: How It All Happened
    All gastroenterologists, most physicians, and many members of the general public are familiar with the discovery of gastric spiral bacteria in Western Australia in the early 1980s and the struggle to convince us that these bacteria, which we now call Helicobacter pylori, were a significant clinical issue. The eventual acceptance of Marshall and Warrren’s ideas resulted in their receiving the Nobel Prize for Medicine or Physiology in 2005. In contrast with the success story of triumph over adversity of these Antipodean pioneers that has been well-disseminated in the medical and lay media, little has been written about why the United States was particularly slow to accept the infectious theory of peptic ulcers.


    Date de mise en ligne : Lundi 19 novembre 2012
    Continuing Medical Education Answers: January 2013


    Date de mise en ligne : Lundi 15 octobre 2012
    Continuing Medical Education Answers: December 2012


    Date de mise en ligne : Mercredi 19 septembre 2012
    Ilaria Russo, Alessandro Luciani, Edoardo Troncone, Carolina Ciacci
    WITHDRAWN: The Endoplasmic Reticulum Stress Response Activates Tissue Transglutaminase and Intestinal Inflammation by Reducing Levels of IκBα
    This article has been withdrawn at the request of the authors. The Publisher apologizes for any inconvenience this may cause.The full Elsevier Policy on Article Withdrawal can be found at (http://www.elsevier.com/locate/withdrawalpolicy.


    Date de mise en ligne : Mercredi 22 août 2012
    Continuing Medical Education Answers: October 2012


    Date de mise en ligne : Jeudi 01 janvier 1970
    Marcelo B.S. Flores, Guilherme Z. Rocha, Danilo M. Damas-Souza, Felipe Osório-Costa, Marília M. Dias, Eduardo R. Ropelle, Juliana A. Camargo, Rita B. de Carvalho, Hernandes F. Carvalho, Mario J.A. Saad, José B.C. Carvalheira
    Retraction notice to “Obesity-Induced Increase in Tumor Necrosis Factor-α Leads to Development of Colon Cancer in Mice” Gastroenterology 2012;143:741–753.e4
    This article has been retracted: please see Elsevier Policy on Article Withdrawal (http://www.elsevier.com/locate/withdrawalpolicy).This article has been retracted at the request of the Editor-in-Chief and Deputy Editor-in-Chief following an investigation into the data that were presented in several figures within the article.A number of images used in this article are believed to be duplicated images. The authors stated that they inadvertently inserted images of the wrong blots in several of the figures, resulting in the duplications; however, they did not address all of the concerns raised.


    Date de mise en ligne : Jeudi 01 janvier 1970
    Information for Authors and Readers
    Gastroenterology is the premiere journal in the field of gastrointestinal disease and is led by an internationally renowned board of editors. As the official journal of the AGA Institute, Gastroenterology delivers up-to-date and authoritative coverage of both basic and clinical gastroenterology and hepatology. Regular features include research and perspectives by leading authorities, reports on the latest technologies for diagnosing and treating digestive diseases, images illustrating important clinical findings, reviews of scholarly media, medical news, meeting summaries, video abstracts, and monthly podcasts.


    Date de mise en ligne : Jeudi 01 janvier 1970
    Elsewhere in The AGA Journals


    Date de mise en ligne : Jeudi 01 janvier 1970
    Table of Contents


    Date de mise en ligne : Jeudi 01 janvier 1970
    Editorial Board


    Date de mise en ligne : Jeudi 01 janvier 1970
    Cover 1